Wnt pathway and APC
Wnt/Wingless Pathway Activation Is Promoted by a Critical Threshold of Axin Maintained by the Tumor Suppressor APC and the ADP-Ribose Polymerase Tankyrase
... as APC activity is disrupted in the majority of colorectal carcinomas, APC-dependent Axin degradation is likely compromised in these cells; thus colon carcinoma cells might be particularly sensitive to ...
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Role of the Wnt pathway in thyroid cancer
... the Wnt/ β-catenin pathway is also necessary for the maintenance of ...this pathway by APC or β-catenin gene mutations promotes the growth of tumor cells exhibit- ing a stem cell-like ...
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The WNT signalling pathway in colorectal cancer
... 1.6.4.9 WNT/β-catenin target genes in colorectal tumours Aberrant WNT/β-catenin signalling in colorectal neoplasms drives tumourigenesis through altered gene ...of WNT signalling is both cell- and ...
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Role of Wnt pathway on rheumatoid arthritis
... the Wnt/β- catenin signaling (canonical Wnt pathway; ...Canonical Wnt pathway determines the fate of mesenchymal stem cells 38 ...of WNT proteins, GSK-3β phosphorilates ...
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Wnt signal transduction pathway and apoptosis: a review
... When wnt ligand is absent, β-catenin is constantly being ...to wnt signaling, or under the circumstances of mutated APC, β-catenin is stabilized, accumulates in the cytoplasm and enters the nucleus, ...
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Bacterial Stimulation of Intestinal Proliferation via the Wnt Pathway in Zebrafish
... of Wnt signaling in intestinal homeostasis comes from mutations that perturb this genetic ...Canonical Wnt signaling is modulated by the levels of β-catenin protein; when abundant, β-catenin protein ...
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Targeting Wnt/β-catenin Pathway in Hepatocellular Carcinoma Treatment
... the APC tumor suppressor, beta-catenin and GSK3 ...T. Wnt pathway inhibition via the targeting of Frizzled receptors results in decreased growth and tumorigenicity of human ...
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Autocrine WNT signaling contributes to breast cancer cell proliferation via the canonical WNT pathway and EGFR transactivation
... This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any ...
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Pharmacological interventions in the Wnt pathway: Inhibition of Wnt secretion versus disrupting the protein-protein interfaces of nuclear factors
... Since Wnt signaling plays a role in nearly all developmental processes, it does not come as a surprise that it is also implicated in many ...the APC gene were discovered in 80% of colorectal cancers, ...
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Induction of LEF1 by MYC activates the WNT pathway and maintains cell proliferation
... numerous WNT-related genes, including the β -catenin co-transcription factor ...by APC loss of function, a common mutation in colon cancer ...the WNT pathway in MYC-expressing ...
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The role of APC in Wnt/ β-Catenin Pathway In gastric Cancer
... example, APC (adenomatosis polyposis coli) is the first of critical gene that mutated in the development of colon cancer, as part of the Wnt signaling pathway is ...that APC including genes ...
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Role of Wnt canonical pathway in hematological malignancies
... of Wnt canonical signaling in carcinomas Wnt canonical signaling is involved in pathogenesis of several carcinomas and the mechanisms of its over-acti- vation are ...of Wnt/ b -catenin sig- naling ...
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Original Article MicroRNA-374a promotes osteogenic differentiation of periodontal ligament stem cells through directly targeting APC/Wnt/β-catenin signaling pathway
... of Wnt/β-catenin signaling, was the target gene of ...of Wnt/β- catenin signaling pathway during ...targeting APC through Wnt/β-catenin signaling pathway and highlighted the ...
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Modulation of the canonical Wnt signaling pathway in bone and cartilage
... the Wnt/β-catenin, but also of the BMP signaling pathway, further sustaining the interaction of these biological routes during various steps of SPC ...of Apc knockdown on osteogenic differentiation ...
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Novel roles for APC family members and Wingless/Wnt signaling during Drosophila brain development
... Is differential adhesion a cause of the phenotypes seen and a feature of the wild-type brain? Double mutant neuroepithelial cells segregate from wild-type neighbors, consistent with differential adhesion between wild- ...
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Regulation of neuritogenesis in neuroblastoma cells by components of the Wnt signalling pathway
... over-expressed APC recruits m-p-GFP away from the ...or APC away from endogenous ...or APC is the limiting component, since binding of m- P-GFP to these proteins must be abrogated simultaneously in ...
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Wnt signal pathway in glioblastoma
... i WNT istaknuti signalni putevi koji omogućuju formiranje izrazitih tumorskih podgrupa (Northcott i ...i WNT možda ipak nisu koaktivirani u ovim tumorima (Zinke i ...na WNT signalni put (He i ...i ...
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Wnt3a induces neuronal differentiation and crosstalk between Wnt/Ca2+-pathway and Wnt/β-catenin pathway
... activates Wnt/Ca 2+ pathway in the differentiating VM cells and how these processes are related to the degradation of β- catenin at the defined time points under a high level of phosphorylated Lrp6 after ...
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Wnt signaling pathway in retinal vascularization
... Angiogenesis is the growth of new vessels from existing vessels by way of endothelial budding. When properly con- trolled, normal retinal development with branching vessels and capillary networks occur. When this is ...
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WNT signalling pathway in oral lesions
... regulate WNT signalling in potentially malignant oral lesions and to analyse the re ce nt a d va nc em e nts t hat w ill im p ro ve o ur understanding in the identification of therapeutic biomarkers for early ...
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