Wnt/planar cell polarity
Coupling of apical basal polarity and planar cell polarity to interpret the Wnt signaling gradient in feather development
... orient cell growth is crucial in tissue ...of Wnt signaling controls the helical growth of feather branches (barbs), and thus the formation of bilateral ...global Wnt gradient is subdivided into ...
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Asymmetry of VANGL2 in migrating lymphocytes as a tool to monitor activity of the mammalian WNT/planar cell polarity pathway
... We have shown earlier that migration of MEC1 cells (and CLL cells in general) depend on the PCP pathway and that cellular migration can be blocked e.g. by inhi- bition of CK1 or by downregulation of DVL2 [10]. Acti- vity ...
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The role of non-canonical Wnt/planar cell polarity signalling in breast cancer progression
... promoting cell migration and invasion through the formation of a functional complex with Dvl and PKCδ (Kho et ...reduced cell migration, implicating a role for VANGL1 and PCP signalling in breast cancer ...
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Gpr125 modulates Dishevelled distribution and planar cell polarity signaling
... gastrulation, Wnt/planar cell polarity (PCP) signaling orchestrates polarized cell behaviors underlying convergence and extension (C&E) movements to narrow embryonic tissues ...
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Tissue/planar cell polarity in vertebrates: new insights and new questions
... A second link between PCP and cilia has come from the identification of the mouse inversin (Invs) gene, which encodes a large adaptor-like protein with homology to the Drosophila PCP protein Diego. Invs was discovered as ...
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Wnt signaling in development and disease
... on Wnt signaling pathways in various aspects of ...establishing planar cell polarity (PCP). Our work suggests that Wnt morphogens regulate development by integrating quantitative and ...
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Ciliary proteins Bbs8 and Ift20 promote planar cell polarity in the cochlea
... Our results, in combination with previous reports on the effects of deletion of Bbs8 (Tadenev et al., 2011), suggest a greater role for Bbs8 in PCP by comparison to other Bbs proteins (Ross et al., 2005). If this is the ...
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Planar cell polarity in moving cells: think globally, act locally
... opposite cell- autonomous effects on filopodial dynamics (Davey et ...diffusible Wnt ligand for commissural axons versus local polarity cues on nearby neuroepithelial progenitors for migrating facial ...
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Cofilin and Vangl2 cooperate in the initiation of planar cell polarity in the mouse embryo
... non-canonical Wnt/PCP pathway is an evolutionarily conserved process that polarizes cells in the plane of an epithelial sheet in the dimension orthogonal to the apical-basal axis of the ...confer planar ...
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Novel Regulators of Planar Cell Polarity: A Genetic Analysis in Drosophila
... A conserved core set of proteins is critical for PCP establishment. These include the multipass trans-membrane proteins Frizzled (Fz), Strabismus/Van Gogh (Stbm/Vang), and Flamingo/Starry night (Fmi/Stan, an atypical ...
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The developmental biology of Dishevelled: an enigmatic protein governing cell fate and cell polarity
... canonical WNT pathway. WNT signals are received by a Frizzled (FZ) receptor and a LRP ...or planar cell polarity (PCP) ...no WNT has yet been implicated in PCP signaling in ...
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Is left right asymmetry a form of planar cell polarity?
... the cell cycle, it localizes to basal bodies, primary cilia, cell-cell junctions, plasma membrane, polarized microtubule pools [where it interacts directly with tubulin and N-cadherin in the ...
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The polarity protein VANG 1 antagonizes Wnt signaling by facilitating Frizzled endocytosis
... as Wnt receptors, modulates Wnt signaling and regulates axon guidance in ...downregulates Wnt signaling to ensure proper axon development in ...inhibiting Wnt signaling in the mouse intestinal ...
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Planar cell polarity controls directional Notch signaling in the Drosophila leg
... the cell and both require Fmi and other proteins for their correct ...other planar polarized systems in Drosophila and in vertebrates, although the details of their localization or cellular actions might ...
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Structure–Function Dissection of the Frizzled Receptor in Drosophila melanogaster Suggests Different Mechanisms of Action in Planar Polarity and Canonical Wnt Signaling
... in planar polarity but gave rise to Fz proteins still able to recruit Dsh to ...in planar polarity signaling being to recruit Dsh, although we also note that in some cases a failure to recruit ...
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Flamingo, a cadherin type receptor involved in the Drosophila planar polarity pathway, can block signaling via the canonical wnt pathway in Xenopus laevis
... of wnt, or of other components of the canonical wnt pathway into the ventral blastomere of an early Xenopus embryo results in the development of a secondary organiser, and subse- quently a second body axis ...
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Wnt and FGF Signaling in C. elegans Vulval Cell Lineage Polarity
... known Wnt pathway components was performed to find additional genes involved in directing vulval ...known Wnt receptors and it was determined that ...
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The cadherin Fat2 is required for planar cell polarity in the Drosophila ovary
... establishing planar cell polarity in the follicle ...to planar cell ...oocyte polarity defects and defects in the number and localization of polar cells (Frydman and Spradling, ...
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A novel function for the Rab5 effector Rabenosyn 5 in planar cell polarity
... apicobasal polarity, perpendicular to the plane of the ...of polarity called planar cell polarity ...epithelial polarity in vivo (Adler, 2002; Eaton, ...Each cell of the ...
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Prickle/spiny legs isoforms control the polarity of the apical microtubule network in planar cell polarity
... hair polarity whereas pk wings have severely disrupted hair polarity (Gubb et ...of polarity reversal (supplementary material ...of polarity in A-abd and P-abd (Lawrence et ...
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