X box binding protein 1 (XBP1)
The transcription factor X-box binding protein-1 in neurodegenerative diseases
... Unfolded Protein Response ...defective, protein aggregates overwhelm cells and affect, among other mechanisms, synaptic function, signaling transduction and cell ...exacerbated protein aggregation, ...
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X-Box Binding Protein 1 Contributes to Induction of the Kaposi's Sarcoma-Associated Herpesvirus Lytic Cycle under Hypoxic Conditions
... contained 1⫻ Platinum quantitative PCR (qPCR) SuperMix-uracil DNA glyco- sylase with ROX (Invitrogen), 300 nM each ORF37 primer,150 nM ORF37 probe (Sigma), and 5 l sample ...
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X-Box-Binding Protein 1 Activates Lytic Epstein-Barr Virus Gene Expression in Combination with Protein Kinase D
... Although XBP-1s alone activates the EBV Rp IE promoter in reporter gene assays and high-level expression of R is suf- ficient to induce lytic EBV infection in many cell types (includ- ing HONE-1/EBV cells) (59), ...
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Induction of Kaposi's Sarcoma-Associated Herpesvirus-Encoded Viral Interleukin-6 by X-Box Binding Protein 1
... FIG 2 Schematic of vIL-6 luciferase (LUC) promoter and constructs showing the location of the potential XBP response elements (XRE) and activation of the vIL-6 promoter constructs by spliced XBP-1. (A) The ...
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IRE1α XBP1 pathway promotes melanoma progression by regulating IL 6/STAT3 signaling
... enzyme 1 (IRE1), and double- stranded RNA-activated protein kinase-like ER kinase (PERK), which act as proximal sensors of ER ...lated protein 78 ...Site 1 and 2 proteases, thus leading to its ...
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Flavivirus Infection Activates the XBP1 Pathway of the Unfolded Protein Response To Cope with Endoplasmic Reticulum Stress
... transmembrane protein with both serine/threonine kinase and RNase activities (61, ...the protein is then activated by ...the X box binding protein 1 gene (XBP1) is ...
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Endoplasmic reticulum stress cooperates with Toll like receptor ligation in driving activation of rheumatoid arthritis fibroblast like synoviocytes
... unfolded protein response (UPR), aimed at relieving the burden by slowing down the global translation rate while increasing production of a selected set of proteins, par- ticularly ER chaperones ...unfolded ...
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Herpes Simplex Virus 1 UL41 Protein Suppresses the IRE1/XBP1 Signal Pathway of the Unfolded Protein Response via Its RNase Activity
... unfolded protein response (UPR) to restore ER ...enzyme 1 (IRE1)-dependent pathway is the most conserved of the three UPR signal ...of X box binding protein 1 ...
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Endoplasmic Reticulum Stress Implicated in the Development of Renal Fibrosis
... promoting protein folding, maturation and secretion to induce ER-associated deg- radation and CCAAT/enhancer binding protein (C/EBP) homologous protein (CHOP) expression ...splicing ...
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Characterization of a Major Histocompatibility Complex Class II X-Box-Binding Protein Enhancing Tat-Induced Transcription Directed by the Human Immunodeficiency Virus Type 1 Long Terminal Repeat
... proteins binding to HIV-1 ...and X-HIV DNA affinity chromatography (D) were assayed for the presence of X-HIV- and X-DRA-binding activities by ...from X-HIV DNA affinity ...
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Thrombin activates a Y box–binding protein (DNA binding protein B) in endothelial cells
... with 1 mL extract and 1 mL glycerol for 1 hour at ...× 1 mm (height) gel slices were cut from the edge of the ...for 1 hour at room temperature in 25 µL gel elution buffer (1% ...
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Serum Y Box Binding Protein 1 (YBX 1) and Interleukin 6 (IL 6) Are Associated with Metastasis in Breast Cancer Patients
... focused on evaluating its serum levels. YBX-1 is secreted through anon-classical vesicle-mediated pathway, from mesangial and monocyticcells under lipopoly- saccharide-induced inflammatory stress [23]. In 2014, ...
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Original Article High expression of Y-box-binding protein 1 is associated with local recurrence and predicts poor outcome in patients with colorectal cancer
... gram. It is well known that patients with inva- sive/metastatic CRC usually have unfavorable outcome and EMT is a key molecular event in cell invasion and metastasis [23]. Recently, increasing studies have regarded ...
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Specificity factors in cytoplasmic polyadenylation
... NUDT21 binds upstream of the poly(A) signal to the upstream element (USE), which contains U(G/A)UA sequences that enhance recognition of the cleavage site. 5,14 A fourth sequence element contributing to cleavage site ...
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Kindlin-2 interacts with β-catenin and YB-1 to enhance EGFR transcription during glioma progression
... EGFR is frequently activated in glioma [23]. Additionally, Kindlin-2 can stabilize EGFR in breast cancer [17]. Therefore, we hypothesized that Kindlin-2 could regulate EGFR signaling in glioma. Immunohistochemical ...
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Endoplasmic reticulum stress induced by an ethanol extract of Coicis semen in Chang liver cells
... Tunicamycin and CSE increased the protein levels of p-PERK and p-eIF2α. Similarly, CSE appeared to in- crease the protein level of glycosylated ATF6α (90 kDa), although the data were not conclusive. To ...
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Shrimp miR-965 induced the human melanoma stem-like cell apoptosis and inhibited their stemness by disrupting the MCL-1-ER stress-XBP1 feedback loop in a cross-species manner
... sequence 1(MCL-1) is an anti-apoptotic protein, which belongs to BCL-2 protein family and is primarily located in the mitochondria, in which it inserts into the mitochondrial membrane via a ...
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A comparison of high mobility group box 1 protein, lipopolysaccharide binding protein and procalcitonin in severe community acquired infections and bacteraemia: a prospective study
... group-box 1 protein (HMGB1) is a nuclear chro- mosomal protein ...this protein especially in relation to sepsis and rheumatoid arthritis ...Lipopolysaccharide-binding ...
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β Cells led astray by transcription factors and the company they keep
... Arx promoter sequence (20). Conversely, whether chromatin modifications them- selves feed back on the functions of TFs in β cells remains to be determined. Thus, PAX6 and NKX2.2 are examples of islet cell TFs that ...
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Original Article Y-box-binding protein-1 and E-cadherin are potential prognostic factors in human bladder carcinoma
... It has previously been demonstrated that YB-1 overexpression is associated with poor survival outcome in patients with solid tumors. Our find- ings supported this hypothesis, given that high YB-1 expression ...
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