Xenograft Model
Relationship between differentially expressed mRNA and mRNA protein correlations in a xenograft model system
... Differential mRNA expression studies implicitly assume that changes in mRNA expression have biological meaning, most likely mediated by corresponding changes in protein levels. Yet studies into mRNA-protein ...
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Characterization of a murine xenograft model for contrast agent development in breast lesion malignancy assessment
... benign xenograft) or false negative (not indicating malignancy for malignant xenograft) greatly reduce accuracy, sensitivity, specificity, positive predictive value and negative predictive value by ...the ...
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Intrathecal Aav9.trastuzumab Tumor Prophylaxis And Treatment In A Murine Xenograft Model Of Her2+ Breast Cancer Brain Metastases
... the xenograft model; Deirdre McMenamin, Christine Draper, and the Penn Gene Therapy Program (GTP) Program in Comparative Medicine for animal procedural assistance; Jamunabai Prakash and the Penn GTP Cell ...
119
Neutrophil-mediated experimental metastasis is enhanced by VEGFR inhibition in a zebrafish xenograft model
... Inhibition of VEGF signalling effectively suppresses localized tumour growth but accelerates tumour invasiveness and micrometastasis by unknown mechanisms. To study the dynamic and reciprocal interactions between tumour ...
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Albumin nanoparticles increase the anticancer efficacy of albendazole in ovarian cancer xenograft model
... Antitumor efficacy of nanoparticle formulations was evaluated in a study using the human OVCAR3 ovarian cancer xenograft model. The mice were treated intraper- itoneally with vehicle, free ABZ (50 mg/kg), ...
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Development of novel anti-cancer strategies utilizing the zebrafish xenograft model
... Malignant melanoma is often linked to increased angiogenesis and a high infiltration with tumor- associated macrophages (TAMs). TAMs influence various processes during tumor development, including immune responses, tumor ...
160
Laser brain cancer surgery in a xenograft model guided by optical coherence tomography
... Tissue cooling can be accomplished for example by contact cooling with a sapphire window, forced air convection or spraying with evaporation. None of these cooling approaches were implemented in experiments reported here ...
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Targeting cyclooxygenase by indomethacin decelerates progression of acute lymphoblastic leukemia in a xenograft model.
... of xenograft model of ALL in NSG ...of xenograft ALL#18 was followed by detection of luminescence intensity using noninvasive in vivo imaging, starting at 11 weeks after IT ...of xenograft ...
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Original Article Development and characterization of pig xenograft model for human hepatocellular carcinoma
... (HCC) model available in ...HCC xenograft model in ...pig model of HCC can be rapidly achieved by orthotopic implantation of human hepatoma cells after partial ...
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Sema3A drastically suppresses tumor growth in oral cancer Xenograft model of mice
... our Xenograft model of oral ...in Xenograft model of mice ...in Xenograft oral cancer mode of mice. Recently, ortho- topic model of oral cancer has been developed and ...
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A pretargeted multimodal approach for image-guided resection in a xenograft model of colorectal cancer
... The current study investigates the use of a tumor- specific multimodal pretargeting strategy. For this purpose, we apply the trivalent bispecific anti-CEA x anti-histamine-succinyl-glycine (HSG) antibody TF2 in ...
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Circadian rhythm characteristics of oral squamous cell carcinoma growth in an orthotopic xenograft model
... oral mucosa of nude mice to establish a nude mouse model of OSCC. Afterwards, mice continued to be housed under 12-hour light/dark cycles. After 3 weeks, when noticeable tumors were present, mice from two cages ...
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Original Article Establishing a patient-derived colorectal cancer xenograft model for translational research
... PDX model stability is whether the engraftment or expansion changes the molecular features of the ...PDX model stability, we compared the PDX with cor- responding donor patient tumor by proteomic analysis, ...
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CRISPR/Cas9 targeting of GPRC6A suppresses prostate cancer tumorigenesis in a human xenograft model
... In the current study, we examined the function of human GPRC6A in prostate cancer progression in vitro and in vivo. We demonstrated that GPRG6A is expressed in human prostate cancer cell lines and has an evolutionarily ...
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Modulation of eicosanoid metabolism in endothelial cells in a xenograft model Role of cyclooxygenase 2
... a model that recapitulates, in part, the situation that would occur in a xenogeneic organ graft, where porcine aortic endothelial cells serve as a model for a donor organ (1, ...
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Treatment of malignant effusion by oncolytic virotherapy in an experimental subcutaneous xenograft model of lung cancer
... Besides the strong effect of the rVACV-mediated in- hibition of VEGF on ME formation other mechanisms such as the VACV-induced inflammatory host response may contribute to the resolution of ME. Reports of using bacterial ...
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Biodistribution and pharmacokinetics of a telodendrimer micellar paclitaxel nanoformulation in a mouse xenograft model of ovarian cancer
... 14 C-PTX (Taxol) accumulation in tumor tissue reached a peak at one hour post injection, then decreased gradually, showing levels close to those in normal organs 16 hours post. injection[r] ...
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Biocompatibility of common implantable sensor materials in a tumor xenograft model
... the model would not then have the bene fi t of using xenografted human tumor cells and therefore would not assess the effects of the implanted bio- materials on a human ...
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FGF2 promotes metastasis of uveal melanoma cells via store-operated calcium entry
... FGF2 treatment increased horizontal and vertical migration and F-actin cytoskeleton assembly, decreased adhesive activity of MUM2B UM cells, together with promotion of metastasis in a mouse xenograft model. ...
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Curcumin and Pancreatic Cancer: A Research and Clinical Update
... Early studies by Li et al. demonstrated that liposomal preparations of curcumin involving lipids 1,2-Dimyristoyl-sn-glycero-3- phosphocholine (DMPC) and 1,2-dimyristoyl-sn-glycero-3- [phospho-rac-(1-glycerol)] sodium ...
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