Xenograft mouse model
Proteomic identification of the lactate dehydrogenase A in a radioresistant prostate cancer xenograft mouse model for improving radiotherapy
... subcutaneous xenograft mouse model and verify the radiosensitization effect from a selected potential ...PC-3 xenograft tumors were established and differential protein expression profiles ...
17
Resolution of psoriasis upon blockade of IL 15 biological activity in a xenograft mouse model
... psoriasis xenograft model, antibody 146B7 reduced the severity of psoriasis, as measured by epidermal thickness, grade of parakeratosis, and numbers of inflammatory cells and cycling ...
11
TRAIL-R2 promotes skeletal metastasis in a breast cancer xenograft mouse model
... this model, and with well documented changes in skeletal metastasis of MDA-MB-231 cells by modulation of E-cadherin [36], knockdown of TRAIL-R2 cells in the osteotropic variant of these cells, which resulted in an ...
15
An improved pre-clinical patient-derived liquid xenograft mouse model for acute myeloid leukemia
... Primary and serial xenotransplantation of AML cells For primary xenotransplantation, BM mononuclear cells were depleted of CD3 + cells using PE selection kit (STEMCELL Technologies) upon labeling with PE- conjugated ...
14
Inhibition of Autophagy with Chloroquine Enhanced Sinoporphyrin Sodium Mediated Photodynamic Therapy-induced Apoptosis in Human Colorectal Cancer Cells
... of xenograft mouse model showed markedly increased apoptosis and significantly reduced tumor size in DVDMS-PDT treated group than Control, and DVDMS-PDT exhibited better antitumor efficiency than ...
12
Upregulated WDR26 serves as a scaffold to coordinate PI3K/ AKT pathway-driven breast cancer cell growth, migration, and invasion
... orthotopic xenograft mouse model of breast cancer, disrupting formation of this complex, by overexpressing WDR26 mutants in MDA-MB231 cells, abrogated PI3K/AKT activation and tumor cell growth and ...
16
<p>ASAP3 is a downstream target of HIF-1α and is critical for progression of lung adenocarcinoma</p>
... Results: In this study, we show that ASAP3 overexpression promotes migration and inva- siveness in human lung adenocarcinoma cells and accelerates tumor progression in a xenograft mouse model. In ...
11
Inhibition of COX-2 expression by topical diclofenac enhanced radiation sensitivity via enhancement of TRAIL in human prostate adenocarcinoma xenograft model
... vivo xenograft mouse model, and suppressed both COX-2 and Ki-67 expression To confirm radiosensitizing effect of diclofenac in vivo, we conducted animal experiments using xenograft ...
9
Targeting v3 andv 5 integrins inhibits pulmonary metastasis in an intratibial xenograft osteosarcoma mouse model
... orthotopic xenograft mouse model that closely mimics the human disease, demonstrate a predominant anti-metastatic activity of cilengitide, implicating that αvβ3/αvβ5 integrins play an important role ...
14
Hypoxia-targeted 131 I therapy of hepatocellular cancer after systemic mesenchymal stem cell-mediated sodium iodide symporter gene delivery
... Tumor hypoxia represents an important challenge in cancer therapy. It results from the rapid proliferation rate of solid tumors causing an outstripping of the oxygen supply provided by the local vasculature [20, 21]. ...
16
<p>Up-Regulation of Tiam1 Promotes the Radioresistance of Laryngeal Squamous Cell Carcinoma Through Activation of the JNK/ATF-2 Signaling Pathway</p>
... An established LSCC xenograft mouse model was used to determine whether up-regulated Tiam1 could regulate the radiation sensitivity of LSCC in vivo. The experiment comprised three groups ( fi ve ...
10
Embryonic zebrafish xenograft assay of human cancer metastasis
... in mouse xenograft models as large numbers of patient primary tumour cells are required for successful ...zebrafish xenograft assay is the capacity to accurately detect and monitor a small number of ...
16
Anti-tumor Efficiency of Lipid-coated Cisplatin Nanoparticles Co-loaded with MicroRNA-375
... and xenograft models have provided evidence that modulating miRNA expression in HCCs has a significant therapeutic potential ...transgenic mouse model, overexpressed YAP caused a dramatic increase in ...
13
Apatinib inhibits VEGF signaling and promotes apoptosis in intrahepatic cholangiocarcinoma
... Figure 7: Apatinib suppressed anti-apoptotic cell growth in ICC cells. a. Apatinib treatment promoted apoptotic cell death in RBE and SSP25 cells. Cell apoptosis was determined by Annexin V-Flow cytometry method and ...
10
Oncolytic Herpes Simplex Virus 1 Encoding 15-Prostaglandin Dehydrogenase Mitigates Immune Suppression and Reduces Ectopic Primary and Metastatic Breast Cancer in Mice
... Oncolytic herpes simplex virus 1 (HSV-1) viruses armed with immunomodulatory transgenes have shown potential for enhanced antitumor therapy by overcoming tumor-based immune suppression and promoting antitumor effector ...
9
Original Article The role of PET imaging probes for early monitoring the response to tamoxifen therapy in a xenograft nude mouse model of ER-positive breast cancer: comparison of 18 F-FDG, 18 F-FES, and 18 F-FLT
... the response to tamoxifen treatment as early as 3 days in breast cancer with a mouse xeno- graft model of ER+ breast cancer. Additionally, immunohistochemical (IHC) analyses of ERα, ERβ, glucose transporter ...
10
The effects of ponatinib, a multi-targeted tyrosine kinase inhibitor, against human U87 malignant glioblastoma cells
... other inhibitors have to be developed. Here, we reported ponatinib, a multi-targeted tyrosine kinase inhibitor, against glioblastoma cells in vitro and in vivo. We demonstrated that ponatinib efficiently decreased cell ...
7
FGF4 induces epithelial-mesenchymal transition by inducing store-operated calcium entry in lung adenocarcinoma
... 25, 26, 35]. In this study, we observed that the expression of phosphorylated AKT and ERK in FGF4-stimulated cells were not increased compared with control cells. On the other hand, FGF4 treatment remarkably upregulated ...
16
Activated platelets inhibit hepatocellular carcinoma cell differentiation and promote tumor progression via platelet-tumor cell binding
... murine model, targeting of platelet membrane receptor GPIIb/IIIa, GPIb-IX-V or GPVI reduced pulmonary metastasis ...a mouse model of pancreatic caner and breast cancer [50, ...
14
FGF2 promotes metastasis of uveal melanoma cells via store-operated calcium entry
... The mouse xenograft model showed that MUM2B cells with FGF2 stimulation grew into larger tumor masses and were prone to ...and mouse xenograft model samples were used to confirm ...
12