XRCC1 gene
The alterations of XRCC1 gene’s polymorphism with a different SNP is involved in breast cancer
... In order to investigate the polymorphism of XRCC1 gene in codon 399, the RLFP technique was employed, with using MSPI restriction enzyme. In this account, 10 L of PCR product, 48ML distilled water, 2L ...
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Association Study of Single Nucleotide Polymorphisms in XRCC1 Gene with the Risk of Gastric Cancer in Chinese Population
... 1 gene (XRCC1) is one of the most important can- didate genes for influencing gastric cancer ...in XRCC1 gene with gastric cancer risk in Chinese Han ...in XRCC1 gene were inves- ...
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Association between the C.1161G>A and C.1779C>G Genetic Variants of XRCC1 Gene and Hepatocellular Carcinoma Risk in Chinese Population
... quences GenBank ID: NC_000019.9, NM_006297.2 and NP_006288.2, the sequence analysis suggested that c.1161G>A allelic variant was a synonymous muta- tion, which caused by G to A mutations in exon10 of XRCC1 ...
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Original Article Assoication of XRCC1 gene polymorphisms with risk of non-small cell lung cancer
... 18]. XRCC1 is located on chromo- some 19q13.2-13.3, and plays gene product is implicated in single-strand break repair and BER mechanisms ...that XRCC1 gene polymorphisms may influence the ...
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Original Article Association of GSTP1 and XRCC1 gene polymorphisms with clinical outcome of advanced non-small cell lung cancer patients with cisplatin-based chemotherapy
... and XRCC1 gene polymor- phisms in advanced NSCLC patients with cisplatin-based ...A313G, XRCC1 Arg194Trp, Arg280His and Arg399Gln were conducted using polymerase chain reaction restriction fragment ...
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Genetic polymorphisms in DNA base excision repair gene XRCC1 and the risk of squamous cell carcinoma of the head and neck
... the XRCC1 gene have been identified at codon 194 (C > T substitution at position 26304, exon 6, Arg to Trp) and 399 (G > A substitution at position 28152, exon 10, Arg to ...The XRCC1 Arg399Gln ...
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Review Article Association between XRCC1 Arg399Gln, Arg280His, Arg194Trp polymorphisms and cervical cancer risk: a pooled analysis based on Chinese individuals
... (XRCC1) gene polymorphisms may alter DNA repair activity by affecting the interaction of other enzyme protein with XRCC1, so as to increase the risk of cancer [4, ...between XRCC1 Arg399Gln, ...
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Original Article The relationship of DNA repair gene XPD, XRCC1, OGG1, APE1, and WRN polymorphism with the risk of age-related cataract in Hani people from Mojiang region in Yunnan
... XPD, XRCC1, OGG1, APE1, and WRN single nucleotide polymorphisms (SNPs), to clarify their relation- ship with ARC in Hani patients from Mojiang region in ...XPD, XRCC1, OGG1, APE1, and WRN SNP in Hani ...
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Original Article Association of the XRCC1 Arg280His polymorphism with leukemia risk: a meta-analysis
... To evaluate the impact of ethnicity and cancer type as potential confounding factors, we per- formed subgroup analyses (Figures 3 and 4). In stratified analysis by race, the included studies were classified as Asians, ...
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Original Article Association between XRCC1 and XRCC3 gene polymorphisms and risk of thyroid cancer
... that XRCC1 and XRCC3 gene polymorphisms may modify the risk for cancer, including lung cancer, breast cancer, glioma, gastric cancer and colorectal cancer [14, ...that XRCC1 Arg194Trp polymorphism ...
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Quantitative assessment of the associations between XRCC1 polymorphisms and bladder cancer risk
... by XRCC1. When damage occurs, XRCC1 recruited by DNA glycosylases, acts as a platform by regulating and coordinating a whole list of BER proteins and single strand break repair (SSBR) machinery ...the ...
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Original Article Senile cataract and genetic polymorphisms of APE1, XRCC1 and OGG1
... and XRCC1 are the key enzymes in base excision repair pathway ...OGG1 gene is located on chromosome ...[30]. XRCC1 gene locates on chromosome ...this gene is involved in the efficient ...
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<p>Association of <em>XRCC1</em>, <em>XRCC2</em> and <em>XRCC3</em> Gene Polymorphism with Esophageal Cancer Risk</p>
... isms. XRCC1 protein as a part of Base excision repair (BER) pathway plays an ef fi cient role in repairing DNA single-strand ...the XRCC1 gene located on ...Two XRCC1 polymorphisms, ...
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Original Article Role of GSTP1 Ile105Val and XRCC1 Arg194Trp Arg280His and Arg399Gln gene polymorphisms in the clinical outcome of advanced non-small cell lung cancer
... size. XRCC1 is considered as a scaffold factor in base excision repair, and the XRCC1 Arg194Trp, Arg280His and Arg399Gln polymorphisms are associated with the change of XRCC1 protein activity to ...
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Association between polymorphisms in DNA repair gene <em>XRCC1</em> and non-melanoma skin cancer risk: a meta-analysis
... of XRCC1 gene might contribute to impair DNA repair, thus playing a role in heightening the risk of ...of XRCC1 gene have been identified: amino acid substitution between arginine and ...
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Genetic polymorphisms in XRCC1 genes and colorectal cancer susceptibility
... by XRCC1 across several cancer types [24, 25]. So, the activity of XRCC1 protein is crucial to individuals to prevent the formation of mutations induced by chemical carcino- gens in cigarette ...and ...
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Original Article X-ray repair cross-complementing protein 1 polymorphisms and risk of nasopharyngeal carcinoma: a meta-analysis in the Chinese population
... of XRCC1 may increase the risk of cancers by impairing the inter- action of XRCC1 with other enzy- matic proteins and consequently altering DNA repair activity [18, ...19]. XRCC1 polymorphisms have ...
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Association between Polymorphisms of XRCC1 and TP53 Genes and Endometriosis
... of XRCC1 gene together with other gene polymorphisms such as TP53, may increase the precise rate of diagnosis, and those with higher risk may be screened out and advised to take some strategies for ...
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Click here to download PDF version of the article !
... for XRCC1 gene and its SNP (rs25487) and (rs1799782) was obtained from SWISS-Protein database and from National Centre for Biotechnology Information (NCBI) database ...variant XRCC1 protein ...
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The association of XRCC1gene single nucleotide polymorphisms with response to neoadjuvant chemotherapy in locally advanced cervical carcinoma
... between XRCC1 gene polymorphisms at codon 194 and NAC response in cervical cancer, recently, Kim and his colleagues reported 66 patients with cervical cancer undergoing platinum- based NAC, the results ...
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