YAP/TAZ
RNAi screens for Rho GTPase regulators of cell shape and YAP/TAZ localisation in triple negative breast cancer.
... (2) YAP/TAZ ratio (YAP/TAZ activation); (3) and sum of nuclear region and ring region YAP/TAZ intensities normalised to nuclear area (hereafter referred to as ‘total ...region ...
13
Vascular stiffness mechanoactivates YAP/TAZ dependent glutaminolysis to drive pulmonary hypertension
... of YAP/TAZ as a central mediator of glutaminolysis also advances our understanding of the intricate control of metabolism by Hippo ...that YAP and TAZ together, but not alone (data not shown), ...
24
<p>YAP/TAZ: a promising target for squamous cell carcinoma treatment</p>
... that YAP restricted nuclear translocation of disheveled (DVL) and the regeneration of intestinal ...48 YAP/TAZ can also interact with the Notch signaling pathway to regulate intestinal ...of ...
8
Yap and Taz play a crucial role in neural crest derived craniofacial development
... targeting Yap, Taz and Hippo kinases Lats1 and Lats2 were purchased from Dharmacon and the transfections were performed by following a typical RNAiMAX transfection procedure (Thermo Fisher ...
12
Dropwort-induced metabolic reprogramming restrains YAP/TAZ/TEAD oncogenic axis in mesothelioma
... the YAP/TAZ/TEAD Hippo ...the YAP/TAZ transcriptional co-activators is regulated by metabolic pathways, such as mevalonate synthesis and aerobic glycolysis, and by the nu- trient-sensing ...
22
A novel role for microRNA-129-5p in inhibiting ovarian cancer cell proliferation and survival via direct suppression of transcriptional co-activators YAP and TAZ
... of YAP and TAZ contributes to the development and progression of many cancers including colon, lung, liver, esophageal and ovarian cancer ...influence YAP/TAZ expression and activity by ...
11
Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms
... of YAP and TAZ could be observed in many tumors of different origins, including prostate can- cer, cervical squamous cell carcinomas, meningioma, squamous cell carcinoma of skin, malignant mesothe- lioma, ...
14
Epicardial YAP/TAZ orchestrate an immunosuppressive response following myocardial infarction
... in the infarcted myocardium of epicardial YAP/TAZ–mutant mice 2 weeks after MI injury (Supplemental Figure 5B). This finding may be secondary to that of deficient Tregs in the injured myocardium (i.e., loss ...
14
Antitumor activity of curcumin is involved in down-regulation of YAP/TAZ expression in pancreatic cancer cells
... of YAP and YAP-mediated transcriptional activation in osteoblastoma and HEK293 cells ...to YAP in vitro and to inhibit the interaction of YAP with TEAD ...of YAP in this ...for ...
13
Dickkopf-3 links HSF1 and YAP/TAZ signalling to control aggressive behaviours in cancer-associated fibroblasts.
... β-catenin, TAZ and Tubulin in human mammary NFs (GS1 and GS6) and CAFs (TB163, TB165, ...of YAP/TAZ and β-catenin CAF-specific gene signatures in normal and cancerous stroma from breast (GSE9014), ...
55
YAP/TAZ regulates TGF-β/Smad3 signaling by induction of Smad7 via AP-1 in human skin dermal fibroblasts
... for Fig. 5g. Figure S6 YAP/TAZ knockdown did not alter AP-1 family transcription factors mRNA expression. Primary dermal fibroblasts were transfected with non-specific control siRNA or YAP/TAZ ...
12
Prognostic value of the Hippo pathway transcriptional coactivators YAP/TAZ and β1-integrin in conventional osteosarcoma
... of YAP: YAP expression induced epithelial- mesenchymal transition, abolished apoptosis and promoted proliferation ...[3]. YAP expression is also linked to oncogenic properties in several human ...
9
Suppression of YAP/TAZ-Notch1-NICD axis by bromodomain and extraterminal protein inhibition impairs liver regeneration
... that YAP/TAZ overexpression promotes proliferation of hepatocytes [22, ...by YAP/TAZ ...of Yap and Taz in the liver tissues and primary hepatocytes were significantly lower in ...
13
Integration of mechanical and chemical signals by YAP and TAZ transcription coactivators
... promoted YAP protein level by activating YAP transcription ...or TAZ revealed that 74% of β-catenin target genes are also dependent on TAZ ...suggest TAZ as a fundamental effector of ...
9
Regulation of cellular quiescence by YAP/TAZ and Cyclin E1 in colon cancer cells: Implication in chemoresistance and cancer relapse
... coactivator YAP is functionally targeted by stress signals, oncogenic GPCR and Wnt signaling driving colon cancer progression [46, ...oncogenic YAP mediates tumor growth through potentiation of CREB ...
14
YAP/TAZ regulates sprouting angiogenesis and vascular barrier maturation
... that YAP/TAZ, a transcriptional coactivator that acts as an end effector of Hippo signaling, is critical for sprouting angiogenesis and vascular barrier formation and ...of Yap/Taz led to ...
22
Yap and Taz are required for Ret dependent urinary tract morphogenesis
... Embryonic samples from timed matings (day of vaginal plug=E0.5) were collected, fixed in 4% paraformaldehyde overnight (O/N) at 4°C, serially dehydrated and then embedded in paraffin. Microtome sections of 7 µm thickness ...
8
Yap/Taz regulate alveolar regeneration and resolution of lung inflammation
... of Yap and Taz, the mediators of the Hippo ...lacked Yap/Taz in AECIIs exhibited prolonged inflammatory responses in the lung and were delayed in alveolar epithelial regeneration during ...
17
The Hippo pathway effectors TAZ and YAP in development, homeostasis and disease
... of YAP. Nuclear YAP levels are elevated in stem cell compartments of the intestinal epithelium (Camargo et ...nuclear YAP promotes progenitor proliferation (Cai et ...of Yap impairs the ...
13
The Hippo transducers TAZ/YAP and their target CTGF in male breast cancer
... co-express TAZ, or YAP, and CTGF may have inferior survival compared with their negative ...the TAZ/CTGF and YAP/CTGF phenotypes were predictive of overall survival in: i) patients whose ...
11