Yes-associated protein (YAP)
Aberrant methylation of yes-associated protein (YAP1) as a potential biomarker in breast cancer
... Yes-associated protein (YAP) gene is mapped to chromosome region 11q22 amplicon [7]. YAP1 is con- sidered a specific transcriptional activator and a leading effector of the Hippo tumor ...
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Original Article Expression of Yes-associated protein (YAP) in breast phyllodes tumor
... PT. Yes-associated protein (YAP) is a transcription coactivator and it is believed that YAP could act as an oncogene in the nucleus although phos- phorylated YAP (pYAP) is ...
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Original Article Yes associated protein is a poor prognostic factor in well-differentiated lung adenocarcinoma
... and Yes-associated protein ...and YAP as either of a tumor suppressor gene or an ...adenocarcinoma. YAP and LATS protein expression was assessed in 167 surgically resected lung ...
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Polyomavirus Small t Antigen Interacts with Yes-Associated Protein To Regulate Cell Survival and Differentiation
... both Yes-associated protein 1 (YAP1) and YAP2, inte- gral parts of the Hippo signaling pathway, which is a subject of increasing interest in human ...of YAP, is also found in PyST complexes. ...
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Arenobufagin induces MCF-7 cell apoptosis by promoting JNK-mediated multisite phosphorylation of Yes-associated protein
... Yes-associated protein (YAP), one of the Hippo sign- aling pathway effectors, functions as a key node of multiple signaling pathways and plays multiple roles by interacting with various ...
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ORIGINALRESEARCH Curcumin Inhibits the Tumorigenesis of Breast Cancer by Blocking Tafazzin/Yes-Associated Protein Axis
... and Yes-associated protein (YAP) are key effectors of Hippo signaling pathway that are involved in the home- ostasis of the internal ...and YAP induces the epithelial mesenchymal ...
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Yes-associated protein (YAP) binds to HIF-1α and sustains HIF-1α protein stability to promote hepatocellular carcinoma cell glycolysis under hypoxic stress
... Yes-associated protein (YAP) is a transcriptional activa- tor in the Hippo signaling, while Hippo signaling is a highly conserved tumor suppressor pathway, and it de- creases YAP ...
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Integrin α2β1 inhibits MST1 kinase phosphorylation and activates Yes-associated protein oncogenic signaling in hepatocellular carcinoma
... target Yes-associated protein (YAP) to maintain organ homeostasis, which is commonly inactivated in many types of ...activating YAP oncogene in hepatocellular carcinoma (HCC) remains ...
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Original Article Expression of Yes-associated protein (YAP) in metastatic breast cancer
... of Yes-associated protein (YAP) in differ- ent metastatic sites in metastatic breast cancer and to determine the clinical implications of these ...of YAP and phospho-YAP in ...
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<p>Curcumin Inhibits the Tumorigenesis of Breast Cancer by Blocking Tafazzin/Yes-Associated Protein Axis</p>
... and Yes-associated protein (YAP) are key effectors of Hippo signaling pathway that are involved in the home- ostasis of the internal ...and YAP induces the epithelial mesenchymal ...
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Original Article Overexpression of yes-associated protein contributes to apoptosis of lung cancer
... tumorigenesis. Yes- associated protein (YAP), a candidate human oncogene, is one of the two main downsream effectors of Hippo ...the Yap play a conserved role in cell apoptosis of ...
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Original Article Yes-associated protein (YAP) is differentially expressed in tumor and stroma according to the molecular subtype of breast cancer
... of Yes-associated protein (YAP) and phosphory- lated YAP (pYAP) protein and to verify the clinical implication of the expression of YAP protein in human breast ...
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Original Article Yes-associated protein 1 promotes bladder cancer invasion by regulating epithelial-mesenchymal transition
... of Yes-associated protein 1 (YAP1) in bladder cancer, and to study its role in regulating epithelial-mesenchymal transition in bladder cancer ...
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The role of Yes-associated protein (YAP) in vertebrate development
... According to the current literature, YAP’s interaction with the TEAD family of transcription factors clearly has a profound affect on developmental outcomes; however, the canonical definition of classifying nuclear ...
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Yes associated protein (YAP) is a negative regulator of chondrogenesis in mesenchymal stem cells
... against YAP (Novus Biologicals, Littleton, CO, USA #NB110-58358), pYAP (Cell Signaling Technology #4911), or isotype control antibody, was performed as previously described ...human YAP transcript variants ...
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Yes-Associated Protein (Yap) Is Required for Early Embryonic Development in Zebrafish (Danio Rerio)
... reduced Yap ex- hibit marked increase in cell death of brain at 24 hpf ...examined yap-MO-injected embryos at multiple time points during the first 24 h of development and compared them with their wild-type ...
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Yes-Associated Protein (Yap) Is Necessary for Ciliogenesis and Morphogenesis during Pronephros Development in Zebrafish (Danio Rerio)
... in yap morphants is very similar to that of IFT complex B mutants and arl13b mutants[9, ...B protein local- ized to the Golgi apparatus in addition to the cilia and centrosome, and IFT88 is the core ...
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The hypoxia conditioned mesenchymal stem cells promote hepatocellular carcinoma progression through YAP mediated lipogenesis reprogramming
... of yes-associated protein (YAP) in HCC cells by immunofluorescence, western blot and real-time PCR, in order to detect the alterations of Hippo ...
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Original Article LATS2-mediated YAP1 phosphorylation is involved in HCC tumorigenesis
... Abstract: YAP (yes-associated protein) is a transcriptional co-activator that acts downstream of the Hippo signaling pathway and regulates multiple cellular processes, including proliferation ...
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<p>Melatonin Regulates Cisplatin Resistance and Glucose Metabolism Through Hippo Signaling in Hepatocellular Carcinoma Cells</p>
... 23 Yes- associated protein (YAP), a key downstream effector of Hippo, has been widely investigated in human disease ...and YAP was shown to signi fi cantly inhibit the growth of HCC ...
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