Zap-70
Original Article Western blotting was used to detect ZAP-70 molecule from γδΤ cells in peripheral blood
... of the total γδΤ population. In our study, we used Mtb-Ag to stimulate PBMC obtained from 5-10 ml of peripheral blood. This method is characterized by quick γδΤ cell proliferation and higher cytotoxicity effect, ...
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Using the geometric mean fluorescence intensity index method to measure ZAP-70 expression in patients with chronic lymphocytic leukemia
... kinase 70 kDa (ZAP-70) in chronic lym- phocytic leukemia (CLL) is associated with more aggressive disease and can help differentiate CLL from cases expressing mutated or unmutated immunoglobulin ...
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Combined analysis of ZAP 70 and CD38 expression in sudanese patients with B cell chronic lymphocytic leukemia
... and ZAP-70 expressions have been proposed as less expensive and time-consuming surro- gates for (IgVH) mutational status [14, ...of ZAP-70 and CD38 expressions analy- sis provided ...
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High intracellular Zn2+ ions modulate the VHR, ZAP-70 and ERK activities of LNCaP prostate cancer cells
... the ZAP-70/VHR/ERK-associated pathways modulate the prostate cancer cell growth is currently unclear, but an earlier study reported that ZAP-70 activates SLP76 and its associated proteins ...
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Prognostic impact of ZAP 70 expression in chronic lymphocytic leukemia: mean fluorescence intensity T/B ratio versus percentage of positive cells
... of ZAP-70 positivity in a TTT ...three ZAP-70 readouts was chosen at the highest value of the c index, calculated for all the possible cut-off values of ZAP-70 ...
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Proliferative index and expression of CD38, Zap-70, and CD25 in different lymphoid compartments of chronic lymphocytic leukemia patients
... and Zap-70 in different compartments of CLL ...CD25, Zap-70, and Ki-67 antigens in the peripheral blood, bone marrow, spleen, and lymph nodes biopsies of patients with CLL, splenic marginal ...
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ZAP 70 Phosphorylation and other prognostic factors in adult B chronic lymphocytic leukaemia patients
... of ZAP-70 between treated and untreated patients 132 Figure ...between ZAP-70 negative and ZAP-70 positive patients 134 Figure ...<20% ZAP-70 expression who ...
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In vivo correction of ZAP 70 immunodeficiency by intrathymic gene transfer
... bp); ZAP-70, ZAP-70 cDNA; eGFP, eGFP cDNA; WPRE, posttranscriptional cis-acting regulatory ele- ment of the woodchuck hepatitis virus (587 bp); LTR-SIN, self-inactivating 3′-LTR deleted of 400 ...
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Original Article Comparison of Bcl-2, CD38 and ZAP-70 Expression in Chronic Lymphocytic Leukemia
... or ZAP-70 status (positive versus ...of ZAP-70 positive cases is lower than that reported for some previous studies [22] and the proportion of discordant CD38 positive, ZAP-70 ...
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Alternative expression of TCRζ related genes in patients with chronic myeloid leukemia
... The expression level of the TCRζ, FcεRIγ, ASF/SF-2, ZAP-70, and β2-microglobulin (β2M) genes was deter- mined by SYBR Green I real-time PCR. Briefly, PCR was performed in a 20 μL total volume that contained ...
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Knorr, Thomas (2001): Biochemische und funktionale Untersuchungen zur Regulation von ADP-Ribosylierungsfaktoren und Proteintyrosinkinasen in der Aktivierung von Lymphozyten. Dissertation, LMU München: Fakultät für Chemie und Pharmazie
... von ZAP-70(YF-C) eine wichtige Rolle ...von ZAP-70(YF-C) ist möglicherweise sowohl auf die erhöhte Kinaseaktivität dieser Mutante als auch auf den schützenden Einfluss der vermehrten Bindung ...
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HIV infection induced posttranslational modification of T cell signaling molecules associated with disease progression
... and ZAP-70 antibodies to lysates of T cells of HIV patients treated with DTT ...and ZAP-70 in lysates of T cells of healthy do- nors were not dependent on DTT treatment (data not ...and ...
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Activation of the T-cell receptor signaling pathway by Nef from an aggressive strain of simian immunodeficiency virus.
... The Nef from a highly virulent strain of simian immunodeficiency virus (SIV), SIVpbj14, and a Nef from the traditional strain SIVmac239 bearing the mutation from RQ to YE (YE-Nef) both induce an acute lethal disease in ...
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Discovery of a diaminoquinoxaline benzenesulfonamide antagonist of HIV 1 Nef function using a yeast based phenotypic screen
... rather than Nef directly. However, using an in vitro kinase assay and recombinant purified Hck and Zap-70, we were unable to detect direct inhibition of kinase activity by DQBS. A more likely mechanism of ...
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The T cell cometh: interplay between adaptive immunity and cytokine networks in rheumatoid arthritis
... of 70 kDa (ZAP-70), which causes abnormal thymic T cell selection and survival of autoreactive clones (see the related article beginning on page ...
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Role of microRNA in chronic lymphocytic leukemia onset and progression
... patients, the loss of miR-15a/16-1 expression shifts the balance not only toward higher levels of anti-apoptotic Bcl2 [10,23] but also toward higher levels of pro-apoptotic p53. Consequently, the number of apoptotic ...
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Assessment of red blood cell distribution width as a prognostic marker in chronic lymphocytic leukemia
... for ZAP-70 positive/negative, CD38 positive/negative, clinical classification early/advanced and cytogenetic risk standard/high, respectively, to find another significant cut-off points for RDW ...for ...
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Index (Volume 70)
... and naval actions/blockades, 19 prisoners of war, repatriation of, 13-14 violations of, provision regarding, 27n146 Repatriation. See Civilian sanctuaries[r] ...
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Introduction (Volume 70)
... Broader in its coverage of methods and means of warfare is The LAw of War Since 1949 (1995), a sweeping survey of the major post-war instruments governing armed conflic[r] ...
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AN IMPROVEMENT TO THE ANTICORROSIVE PROPERTIES OF EPOXY POWDER COATING BY ZINC PHOSPHATE AND ZINC ALUMINUM PHOSPHATE PIGMENTS
... of ZAP compared to ZP; also, the results show the better anticorrosion perfor- mance of ZAP-loaded coating compared to the sample containing ...containing ZAP compared to the one modified by ZP ...
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