ZDF (fa/fa) rats
Treatment of peripheral diabetic neuropathy in Zucker diabetic fatty (ZDF) rats with cariporide
... the ZDF Type 2 diabetic model is the restriction of the studies to male ...in ZDF rats was progressive and a difficult condition to reverse ...treating ZDF rats with different classes ...
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Prediction of Methionine and Homocysteine levels in Zucker diabetic fatty (ZDF) rats as a T2DM animal model after consumption of a Methionine-rich diet
... T2DM rats, on the basis of our ...in rats for estimating the influ- ence of betaine on cardiovascular ...al., rats were treated with saline and intravenous high-dose methionine ...the ZDF ...
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Treatment with CNX-011-67, a novel GPR40 agonist, delays onset and progression of diabetes and improves beta cell preservation and function in male ZDF rats
... treated rats in this study the increase in expression of PDX1 protein and in- crease in insulin stained area (Figure 7) and a reduction in beta cell apoptosis suggest that CNX-011-67 treat- ment could have ...
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Metabolic syndrome influences cardiac gene expression pattern at the transcript level in male ZDF rats
... male ZDF rats including obesity, fasting hyperglycemia, hyperlipidemia, hyperinsulinemia, insulin resistance, and impaired glucose tolerance as well as increased cardiac nitrosative ...of ZDF ...
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Leptin or troglitazone induced lipopenia protects islets from interleukin 1beta cytotoxicity
... of rats with widely vary- ing islet TG content. Islets of obese ZDF rats were fat laden, while those of leptin-overexpressing rats were fat ...(1/1) ZDF rats and obese (fa/fa) ...
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Intrarenal Oxidative Stress and Augmented Angiotensinogen are Precedent to Renal Injury in Zucker Diabetic Fatty Rats
... Male ZDF rats (ZDF-fa/fa, 12 weeks of age, N=6) and age-matched control male lean rats (ZDF-+/?, 12 weeks of age, N=6) were purchased from Charles River ...These rats were ...
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Role of nitric oxide in obesity induced beta cell disease
... Figure 1. Effects of long-chain FFA with and without nicotinamide (NIC) or aminoguanidine (AG) on islets isolated from 6–7-wk-old Wistar rats, prediabetic obese ZDF rats (fa/fa), and lean ...
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Diabetic cardiomyopathy: effects of fenofibrate and metformin in an experimental model – the Zucker diabetic rat
... Male ZDF rats (fa/fa) (n = 35) and their control littermates (controls C, +/+) (n = 15) (Charles River, L'Arbresle, France) arrived at the age of six weeks and were housed in an animal facility with ...
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Antidiabetic treatment restores adiponectin serum levels and APPL1 expression, but does not improve adiponectin-induced vasodilation and endothelial dysfunction in Zucker diabetic fatty rats
... (ZL) rats (fa/-) and twenty male Zucker diabetic fatty (ZDF) rats (fa/fa) were studied from an age of 11 weeks until an age of 22 ...the ZDF rats, six were kept as untreated controls ...
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Electrocardiographic changes with the onset of diabetes and the impact of aerobic exercise training in the Zucker Diabetic Fatty (ZDF) rat
... Although we did not measure autonomic function directly, ECG indicators of autonomic dysfunction were observed in the ZDF rats at baseline with HRV altera- tions, tachycardia and QT interval prolongation. ...
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Deciphering bacterial community changes in zucker diabetic fatty rats based on 16S rRNA gene sequences analysis
... in ZDF rats and the lean littermates (ZL rats) by Miseq Sequencing ...a ZDF rat containing a very low number of sequences, which was removed from the diversity analysis, all rests met the ...
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Eplerenone prevents salt-induced vascular stiffness in Zucker diabetic fatty rats: a preliminary report
... libitum. Rats were individually housed on a 12-h dark/12-h light ...and ZDF rats received either normal-salt (0.28% NaCl) (ZL, n = 9) (ZDF, n = 9) or high-salt diet ...treated ZDF ...
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Rosiglitazone reverses endothelial dysfunction but not remodeling of femoral artery in Zucker diabetic fatty rats
... younger rats in the common femoral ...in ZDF rats as early as 11 weeks in response to low concen- tration of ACh which may be attributed to the more phys- iologic loading in both inflation and axial ...
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Rodent models of diabetic nephropathy: their utility and limitations
... lean rats by 28 weeks of ...male ZDF rats as they age. Although ZDF rats do not exhibit glomerulo- sclerosis, tubular cell damage, or tubulointerstitial fibrosis at 8 weeks of age, the ...
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Long-term treatment with metformin in the prevention of fatty liver in Zucker diabetic fatty rats
... as ZDF rats develop insulin resistance at a relatively early age (6–8 weeks), and the metformin treatment was started at the age of 8 weeks, our study also suggested that early interference with insulin ...
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Pathophysiological Changes by Short-term Food Restriction in Obese Diabetic Rats
... In ZDF rats at 7 weeks of age, body weight, serum insulin and lipid levels increased as compared with those in ZL rats (Table ...One ZDF rat showed an increase of serum glucose ...the ...
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Effects on Fat Distribution by Food Restriction in Zucker Diabetic Fatty Rats
... In ZDF rats at starting time of an experiment, 9 weeks of age, body weight and serum glucose, insulin, and lipid levels significantly increased as compared with those in ZL rats ...the ZDF ...
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Altered myocardial substrate metabolism is associated with myocardial dysfunction in early diabetic cardiomyopathy in rats: studies using positron emission tomography
... 11-weeks-old ZDF rats [10]. Moreover, at 12 weeks of age, ZDF rats showed increased FA oxidation and decreased carbohy- drate oxidation with only a slight depression of systolic function in ...
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A STUDY ON THERAPEUTIC EFFECTS OF ULTRASOUND FOR THE TREATMENT OF SARCOMA CANCER
... II rats treated with ultrasound therapy in comparison to control Group I ...the rats. Group 3 (DMBA) rats and in Group 4 (DMBA + ultrasound) rats showed significant reduction in body ...4 ...
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Antioxidant potential of guava leaves extracts and their effects on hyperlipidemia
... Guava fruit is enriched in phenols, tannins, flavonoids, fundamental oils, carotenoids, lectins and saponins as well. Leaves of this fruit separate make hypolipidemic and hypoglycemic affect in alloxan treated on ...
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