Zebrafish Model
Hematopoietic stem cells, hematopoiesis and disease: lessons from the zebrafish model
... the zebrafish model has shown promise as an efficient means of prescreening small molecules for drug ...the zebrafish and human homologs, including a nearly identical active site composition ...the ...
11
Neurodegeneration and Epilepsy in a Zebrafish Model of CLN3 Disease (Batten Disease)
... in zebrafish and demonstrated a range of embryonic and larval phenotypes relevant to CLN3 disease: patient signs reproduced include seizures, motor deficits and premature ...that zebrafish cln3 morphants do ...
24
Generation and Characterization of a genetic zebrafish model of SMA carrying the human SMN2gene
... animal model of SMA is to add the hSMN2 as a transgene to an animal with a deleted/mutated ...drosophila, zebrafish, and Xenopus have relied on maternal Smn contributions [11,12] or transient Smn knockdown ...
9
Protection and pathology in TB: learning from the zebrafish model
... of zebrafish eggs provides easy ac- cess to developing ...in zebrafish embryos using antisense morpholino oligonucleo- tides have strongly contributed to the understanding of early mycobacterial ...
13
Intracellular Insulin and Impaired Autophagy in a Zebrafish model and a Cell Model of Type 2 diabetes
... These zebrafish had a significantly higher weight, body mass index (BMI) and more lipid vacuoles in liver cells compared to the normal diet group ...in zebrafish compared to those fed a normal ...
11
Impaired neural development in a zebrafish model for Lowe syndrome
... animal model that recapitulates the disease ...a zebrafish model for Lowe syndrome using stable and transient suppression of OCRL1 ...a model whereby dysregulation of phosphoinositide ...
16
A zebrafish model for functional screening of flow-responsive genes
... developing zebrafish vasculature. If correct, then zebrafish embryos could provide a valuable model for studying the function of genes that are coex- pressed in adult mammalian ...whether ...
14
A Zebrafish Model for a Human Myopathy Associated with Mutation of the Unconventional Myosin MYO18B
... One model envisages the polymer- ization of myosin thick filaments and actin thin filaments in separate multi-protein complexes that subsequently interdig- itate to form the sarcomeres (Holtzer et ...
11
snow white, a Zebrafish Model of Hermansky-Pudlak Syndrome Type 5
... Using the zebrafish to study HPS and LRO biogenesis Zebrafish are an excellent model system to investigate the molecular underpinnings of Hermansky-Pudlak syndrome and elucidate the biology of LROs. Pigment is first ...
23
A Zebrafish Model of Myelodysplastic Syndrome Produced through tet2 Genomic Editing
... Generation of tet2 mutant zebrafish lines by genome editing. Zinc finger nuclease technology (35, 36) was used to induce dou- ble-strand DNA breaks within the coding sequences in exon 7 of the tet2 gene in the ...
17
Aggregation-prone GFAP mutation in Alexander disease validated using a zebrafish model
... To ascertain whether the p.Asp128Asn GFAP allele of the proband is aggregation prone, we first compared expression levels between p.Asp128Asn GFAP and WT GFAP in HEK293T cells by Western blotting and observed comparable ...
9
Identification of compounds with anti-convulsant properties in a zebrafish model of epileptic seizures
... of zebrafish mind bomb mutant embryos, which lack Notch signalling pathway activity, previously demonstrated that expression levels of fos, bdnf and pyya transcripts were increased in the CNS of 3-day-old mutant ...
12
NAD+ improves neuromuscular development in a zebrafish model of FKRP-associated dystroglycanopathy
... adult zebrafish maintained on a 14-h light/10-h dark cycle at ...-503unc zebrafish muscle-specific pro- moter [5], which was used in place of the heat shock gateway 222 5′ ...
23
Whole plant based treatment of hypercholesterolemia with Crataegus laevigata in a zebrafish model
... From 4–8 days post fertilization (dpf ) zebrafish embryos were fed paramecia and housed in 1 L breeding tanks (Aquatic Habitats). Larval fish (8–21 dpf ) were trans- ferred to the main system and fed approximately ...
9
Resident immunity in tissue repair and maintenance: The zebrafish model coming of age
... zebrafish model is also making key contributions to the understanding of tissue immunity in vertebrates, thanks to an impressive availability of transgenic reporter lines for different immune cells/inflammatory ...
12
Zebrafish embryos and larvae as a complementary model for behavioural research
... by zebrafish early life stages is very little ...the zebrafish embryo has a chorion during first 2-3 dpf which is ...the zebrafish embryo to compare the effects on zebrafish and other animal ...
238
Development of novel anti-cancer strategies utilizing the zebrafish xenograft model
... using zebrafish ectopic and orthotopic tumour models. Zebrafish tumour models are advantageous for anticancer compound development as they allow for fast compound screening in vivo with low amounts of ...
160
Impaired light detection of the circadian clock in a zebrafish melanoma model
... in zebrafish clock entrain- ment is likely to contribute to the reduced amplitude rhythms in LD shown in Figure ...this zebrafish model of melanoma, even when one takes into account the fact that the ...
11
Zebrafish and Medaka: new model organisms for modern biomedical research
... tween zebrafish and humans, making zebrafish a feasible model for the study of ...in zebrafish could be conveniently modified by sev- eral approaches, ...the zebrafish model was ...
11
The zebrafish as a model for studying neuroblastoma
... the zebrafish model has emerged as a novel important platform for perform- ing in vivo studies of NB ...pathogenesis. Zebrafish displays several logistic advantages that make it an attractive alter- ...
9