Zinc Finger
KRAB zinc finger proteins
... for zinc finger arrays; that is, with adjacent KRAB-ZFPs differing by either point mutations at DNA-contacting residues of a few ZNFs or substitutions of entire blocks of these motifs (Kauzlaric et ...
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Inactivation of respiratory syncytial virus by zinc finger reactive compounds
... a zinc finger ...The zinc fin- ger motif is located in the N-terminus of the protein, from residues 7 to ...intact zinc finger motif of the M2-1 protein is required for maintaining ...
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Targeted Chromosomal Cleavage and Mutagenesis in Drosophila Using Zinc-Finger Nucleases
... Figure 2.—Modification of zinc-finger coding sequences to correspond to sites in the y gene. In each set the starting amino acid sequences (Start) are given at the top, along with the DNA triplets they ...
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Fear of intimacy mediated zinc transport controls the function of zinc finger transcription factors involved in myogenesis
... of zinc transporters control zinc homeostasis in organisms, but there is little information about their specific developmental ...specific zinc- finger transcription factors (ZFTFs), ...
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Zinc Finger Nucleases as tools to understand and treat human diseases
... designer zinc fin- ger proteins has been the ability to cleave specific sites in large ...termed zinc finger nucleases, or ...two zinc finger trimers are bound to their cognate DNA ...
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The zinc finger region of simian virus 40 large T antigen.
... Such a change in conformation could affect multiple independent functions, including origin binding, transformation, and the function of the active site element of the zinc finger in rep[r] ...
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Identification of conserved C2H2 zinc finger gene families in the Bilateria
... Schematic diagram of a C2H2 zinc-finger motif. The paired cysteines (C) and histidines (H) that bind the zinc ion are shown in yellow and blue, respectively. The linker sequence, shown in green with ...
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Patterning the zebrafish diencephalon by the conserved zinc finger protein Fezl
... The zebrafish fezl gene was identified as a zinc-finger-containing gene induced by Dkk1 (Hashimoto et al., 2000), a secreted antagonist of Wnt signaling (Glinka et al., 1998). fezl has a paralog named fez, ...
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Evaluation and application of modularly assembled zinc finger nucleases in zebrafish
... Zinc-finger nucleases (ZFNs) are chimeric fusions between a zinc-finger protein (ZFP) and the nuclease domain of FokI (Urnov et al., 2010). ZFNs have been employed to achieve heritable ...
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Antiviral activity of influenza virus M1 zinc finger peptides.
... The zinc finger is a novel motif found in proteins which bind to ...single zinc ion; amino acids between these coordi- nation sites project out as fingers ...receptors; zinc fingers are formed ...
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Inhibition of DNA Replication of Human Papillomavirus by Artificial Zinc Finger Proteins
... artificial zinc finger protein (AZP) that was designed to block binding of the replication protein (Rep) to its repli- cation origin, and transgenic Arabidopsis thaliana plants ex- pressing the AZP showed ...
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The zinc finger transcription factor GLI3 is a regulator of precerebellar neuronal migration
... Hindbrain precerebellar neurons arise from progenitor pools at the dorsal edge of the embryonic hindbrain: the caudal rhombic lip. These neurons follow distinct migratory routes to establish nuclei that provide climbing ...
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Inhibition of Virus DNA Replication by Artificial Zinc Finger Proteins
... inactivate antiviral drugs is always a formidable problem (1). Viruses with high mutation rates have escaped the attacks of drugs by mutation of an amino acid(s) in viral enzymes, result- ing in rapid emergence of ...
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Chato, a KRAB zinc finger protein, regulates convergent extension in the mouse embryo
... Here we report the identification and characterization of Chato, a novel KRAB zinc-finger protein required for mammalian convergent extension. Two independent recessive mutant alleles of chato cause ...
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Improving selectivity of DNA–RNA binding zinc finger using directed evolution
... successive zinc fingers ...of zinc finger domains [9] and application of ZFs as targeting modules when fused with effector domains like nucleases, tran- scription activators and repressors ...
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Overexpression and clinical significance of MYC-associated zinc finger protein in pancreatic carcinoma
... MYC-associated zinc finger protein (MAZ) in pancreatic carcinoma (PC), and the biological functions of MAZ in PC ...MYC-associated zinc finger protein, prognosis, cell ...
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The Zinc-Finger Protein SOP1 Is Required for a Subset of the Nuclear Exosome Functions in Arabidopsis
... Correct gene expression requires tight RNA quality control both at transcriptional and post- transcriptional levels. Using a splicing-defective allele of PASTICCINO2 ( PAS2 ), a gene essential for plant development, we ...
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Splice variants of zinc finger protein 695 mRNA associated to ovarian cancer
... The analysis was performed by means of Alternative Splicing ANOVA and the criteria to select genes for exon analysis were: false discovery ratio (FDR) < 0.05 and fold change >3, in at least one probe set. According ...
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A zinc finger protein that regulates oligodendrocyte specification, migration and myelination in zebrafish
... 2 zinc finger of Znf16l to a ...its zinc fingers, the location of the transversion in the st78 allele, and the 4 bp deletion resulting in a frameshift in the st97 ...
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A zinc-finger fusion protein refines Gal4-defined neural circuits
... two zinc fingers of mouse transcription activator EGR1 (previously referred to as ZIF268) with the linker and dimerization domains of Gal4 ...protein, zinc finger Gal4 dimerization 1 (ZFGD1), bound ...
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