Zinc Fingers
A phenyl thiadiazolylidene amine derivative ejects zinc from retroviral nucleocapsid zinc fingers and inactivates HIV virions
... of zinc ions from the HIV-1 NCp7 zinc fingers, inactivating HIV-1 and HIV-2 virions and relieving the protection of the viral RNA by the retroviral nucleocapsid ...dissociate zinc ions from ...
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Intracellular HIV 1 Gag localization is impaired by mutations in the nucleocapsid zinc fingers
... NC zinc fin- gers (ZF) in Gag ...NC zinc fingers play critical roles in the ability of Gag to properly assemble and ultimately to ...NC Zinc fingers caused Gag to accumulate within the ...
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Waking up dormant tumor suppressor genes with zinc fingers, TALEs and the CRISPR/dCas9 system
... developed: Zinc Fingers (ZFs) [10], Transcription Activator-Like Effectors (TALEs) [11], and the Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) system associated with the bacterial Cas9 ...
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Inhibitors of human immunodeficiency virus type 1 zinc fingers prevent normal processing of gag precursors and result in the release of noninfectious virus particles.
... the zinc finger motif, which would be undetectable by the methods employed here, may also contrib- ute to the loss of virus ...the zinc fingers that result in only localized alterations in Gag ...the ...
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The UBR-box and its relationship to binuclear RING-like treble clef zinc fingers
... (usually zinc) and contain a zinc-knuckle, a primary β-hairpin and an α-helix ...the zinc-knuckle and a pair from the beginning of the α-helix bind the zinc ...second zinc ion ...
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The two zinc fingers in the human immunodeficiency virus type 1 nucleocapsid protein are not functionally equivalent.
... Infectivity assay of HIV-1 Zn2+ finger rearrangement mutants with HCLZ cells Virus pNC1/1 pNC2/2 pNC2/1 pNL4-3 wild type None calf thymus DNA Amt of p24A in inoculum no.. of ng/mla focib[r] ...
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The Drosophila Broad-Complex encodes a family of related proteins containing zinc fingers.
... genes are expressed in many tissues, including salivary glands and imaginal discs, and each can encode alter- nate products, the tissue-specific transcriptional out- come of th[r] ...
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Mutations in Human Immunodeficiency Virus Type 1 Nucleocapsid Protein Zinc Fingers Cause Premature Reverse Transcription
... We would assert that the vDNA observed in particles must be synthesized prior to or during the budding process, while virions are still attached to the cell membrane and thus have access to cellular dNTP pools. Support ...
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When is it time for reverse transcription to start and go?
... CCHC zinc fingers, the core is formed of mature Gag proteins but it is mostly globular and does not adopt a condensed cone-shaped structure as seen by electron microscopy ...
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Chemically synthesized zinc finger molecules as nano-addressable probes for double-stranded DNAs
... buffer was made by adding acetylated BSA(Aurion, Wage- ningen NL) to the storage buffer to a final concentration of 1–2%. The peptides were dissolved in the running buffer (at the concentration of 0.5 µg peptide / 500 µl ...
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Elimination of Retroviral Infectivity by N-Ethylmaleimide with Preservation of Functional Envelope Glycoproteins
... NC zinc fingers with either mild oxidizing agents (1, 56, 60) or alkylat- ing agents (as described here) with viruses containing point mutations in NC shows a number of similarities in their phe- ...in ...
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Evaluation and application of modularly assembled zinc finger nucleases in zebrafish
... of zinc fingers recognizing 27 different triplet sequences in the three finger positions of the Zif268 backbone that can be rapidly assembled by PCR into three-finger ZFPs (see Table S1 in the supplementary ...
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C. elegans PAT-9 is a nuclear zinc finger protein critical for the assembly of muscle attachments
... C2H2 zinc fingers in pat-9 sug- gests that PAT-9 could be a nuclear C2H2 zinc finger transcription factor that localizes to promoters and reg- ulates gene ...
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Use of Endogenous Retroviral Sequences (ERVs) and structural markers for retroviral phylogenetic inference and taxonomy
... as seen in figure 1, this order is not maintained when additional XRVs and ERVs are included. It has been shown that some avian retroviruses share similarity with human gammaretroviral (class I) HERV-I elements [23], and ...
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A survey paper on a factors affecting on selection of mechanical gripper
... The fingers are always parallel to original position, without varying its distance to the gripper’s frame as shown in figure ...both fingers, producing parallel or opposed grasp ...
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Experiments with Optical Properties of Skin on Fingers
... Biometric systems based on fingerprint recognition use various sensor technologies for acquirement of fingerprints. The common technologies are: optical, capacitive, ultrasound, e-field, pressure based, electro-optical, ...
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Morphology of order-disorder structures in rapidly solidified L12 intermetallics
... line fingers are imbedded within an amorphous ...width fingers may be explained with recourse to a Mullins & Sekerka type instability, the non-crystallographic branching of an fcc metal is much more ...
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Privacy Augmenting for Fingerprint detection using RSA
... unique mark utilizing some current strategies [16], [17]. At that point, by utilizing proposed coding methodologies, a consolidated particulars layout is produced focused around the details positions, the introduction ...
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Convection, turbulent mixing and salt fingers
... This response to low-frequency shearing represents a previously unreported mechanism by which density fine structure can arise from salt finger convection. The initial vertical scale does not depend upon an intrinsic ...
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Development of the deep flexor tendons and lumbricalis muscle in the hand and foot: a histological study using human mid-term fetuses
... the fingers is divided into four or more muscle slips continuous with just four tendons for each of the fingers, at a level proximal to the carpal tunnel, whereas the flexor digitorum longus muscle of the ...
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