Zn superoxide dismutase
Altered expression of hypothetical proteins in hippocampus of transgenic mice overexpressing human Cu/Zn-superoxide dismutase 1
... The enzyme Cu/Zn-superoxide dismutase 1 (SOD1; E.C.1.15.1.1), which catalyses the conversion of superox- ide radicals into the less toxic hydrogen peroxide (H 2 O 2 ) plays an important role in the ...
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Formation of multinucleated giant cells and microglial degeneration in rats expressing a mutant Cu/Zn superoxide dismutase gene
... Cu/Zn superoxide dismutase 1 (SOD1) gene ...eliminating superoxide, an undesirable byproduct of oxidative phosphorylation and a potential source of oxidative damage, the fact that transgenic ...
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Pivotal role of Cu,Zn superoxide dismutase in endothelium dependent hyperpolarization
... Cu,Zn-superoxide dismutase (Cu,Zn-SOD) plays a pivotal role in endothelium-dependent hyperpolarization, using control and Cu,Zn-SOD–/– ...
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Lipid Rafts in Cryptococcus neoformans Concentrate the Virulence Determinants Phospholipase B1 and Cu/Zn Superoxide Dismutase
... Cu/Zn superoxide dismutase (SOD1) was concentrated six- to ninefold in raft membrane fractions compared with nonraft membranes, whereas the cell wall-associated virulence factor laccase was not ...
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Production and Characterization of RecombinantAspergillus fumigatus Cu,Zn Superoxide Dismutase and Its Recognition by Immune Human Sera
... Cu,Zn superoxide dismutase (SOD) of Aspergillus fumigatus has previously been purified and shown to be immunoreactive to the sera of patients with aspergillosis; however, the purification of large ...
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Surface-exposed proteins of pathogenic mycobacteria and the role of cu-zn superoxide dismutase in macrophages and neutrophil survival
... The selective biotinylation of surface-exposed proteins using membrane impermeable reagents has become an important tool in the study of this subset of the cellular proteome. This study adapted the aforementioned method ...
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The Megavirus Chilensis Cu,Zn-Superoxide Dismutase: the First Viral Structure of a Typical Cellular Copper Chaperone-Independent Hyperstable Dimeric Enzyme
... SODs catalyze the conversion of superoxide radicals to hydro- gen peroxide and dioxygen. There are four families of SODs, de- fined by their metal ion binding partners: Fe, Mn, Ni, or both Cu and Zn. The ...
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Transduction of Cu, Zn superoxide dismutase mediated by an HIV 1 Tat protein basic domain into human chondrocytes
... sufficient xanthine oxidase to produce a rate of reduction of ferricytochrome c at 550 nm of 0.025 absorbance unit per minute. Under these defined conditions, the amount of super- oxide dismutase required to ...
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Immunochemical characterization on pathological oligomers of mutant Cu/Zn-superoxide dismutase in amyotrophic lateral sclerosis
... and affinity-purified using the same peptide. The resultant antibody (anti-SOD1 44 – 53 ) was found to exhibit the in- creased immunoreactivity to the soluble and disulfide- crosslinked oligomers over the folded ...
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Molecular characterization of a cDNA encoding Cu/Zn superoxide dismutase from Deschampsia antarctica and its expression regulated by cold and UV stresses
... Deschampsia antarctica Desv. is a grass specie adapted to the extreme climate of the Maritime Antarctic [20], pre- senting tolerance to low temperatures usually between - 2°C to 6°C in summer and freezing in winter time ...
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Wild-type Cu/Zn-superoxide dismutase is misfolded in cerebrospinal fluid of sporadic amyotrophic lateral sclerosis
... An important precedent can be found in CSF of PD cases, where the activity of a copper-dependent enzyme, ceruloplasmin (Cp), was shown to decrease in spite of the increased copper levels [52]. This is partly because ...
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Cattle serologically positive for Brucella abortus have antibodies to B. abortus Cu-Zn superoxide dismutase.
... Lane 1, amido black-stained blot of BCSP; lane 2, immunoblot incubated with positive control serum from an experimen- tally infected cow (cow 47); lane 3, immunoblot with a negative cont[r] ...
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Cu/Zn superoxide dismutase expression in the postnatal rat brain following an excitotoxic injury
... trite formation at these very early time points in compromised neurons. Although to our knowledge this is the first study describing the expression of Cu/Zn SOD after immature brain damage, studies on adult brain ...
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A Comparison of the Structure and Function of the Highly Homologous Maize Antioxidant Cu/Zn Superoxide Dismutase Genes, sod4 and Sod4A
... FIGURE 7.-RNA blot analysis of L'jod4 and Sod4A mRNA levels in leaf and stem tissue isolated from seedlings treated with paraquat in the light and dark.. Twelveday seedli[r] ...
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Rat lung Cu,Zn superoxide dismutase Isolation and sequence of a full length cDNA and studies of enzyme induction
... pretranslationally mediated in otherwise unmanipulated neonatal rats but translationally controlled in hyperoxic adult rats; and (c) in lungs of rats made tolerant to greater than 95% O2 by allowing 24 h rest in air ...
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Cloning and constitutive expression of Deschampsia antarctica Cu/Zn superoxide dismutase in Pichia pastoris
... It has been determined that the combination of low tem- perature, high light and UV radiation leads to an increase in the production of reactive oxygen species, such as the superoxide anion, hydrogen peroxide and ...
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Oxidative Markers and Antioxidant Defences in Patients Diagnosed with Probable Alzheimer Disease
... INTRODUCTION: Increasing evidence suggests that oxidative stress is associated with aging and several neurodegenerative diseases, including Alzheimer's disease (AD), although the role of oxidative stress in the aetiology ...
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Effects of hypo and hyperoxia on transcription levels of five stress genes and the glutathione system in liver of Atlantic cod Gadus morhua
... Cu/Zn superoxide dismutase (SOD), phospholipid hydroperoxide glutathione peroxidase (GSH-Px), metallothionein (MT), elongation factor 1A (EF1A) and  - actin were designed using the Primer Express ...
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Genotype phenotype relationship in hereditary amyotrophic lateral sclerosis
... Cu/Zn superoxide dismutase; IAHSP: Infantile ascending hereditary spastic paraplegia; JPLS: Juvenile primary lateral sclerosis; JALS: Juvenile amyotrophic lateral sclerosis; SETX: Senataxin; SPG11: ...
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Molecular characterization and rescue of acatalasemic mutants of Drosophila melanogaster.
... SETO, HAYASHI and TENER (1 990) examined the effects of increasing Cu/ Zn superoxide dismutase levels on aging in Drosophila and found that, if affected at all, life span was [r] ...
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