Zucker diabetic fatty
In vivo cannabidiol treatment improves endothelium dependent vasorelaxation in mesenteric arteries of Zucker diabetic fatty rats
... Zucker diabetic fatty rats used in this study were heavier, and had higher glucose levels, than the lean control ...ZDF diabetic rats, a contractile response to ACh was observed in mesenteric ...
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Prediction of Methionine and Homocysteine levels in Zucker diabetic fatty (ZDF) rats as a T2DM animal model after consumption of a Methionine-rich diet
... Background: Although alterations in the methionine metabolism cycle (MMC) have been associated with vascular complications of diabetes, there have not been consistent results about the levels of methionine and ...
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Variability in Zucker diabetic fatty rats: differences in disease progression in hyperglycemic and normoglycemic animals
... The Zucker diabetic fatty (ZDF) rat (fa/fa) is an obese animal model frequently used in type 2 diabetes ...became diabetic as ...nondiabetic Zucker lean rats (ZLRs), and hyperglycemic ...
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Electrocardiographic changes with the onset of diabetes and the impact of aerobic exercise training in the Zucker Diabetic Fatty (ZDF) rat
... The Zucker Diabetic Fatty (ZDF) rat is a model of type 2 ...the diabetic heart disease including ECG studies with this animal model is ...
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Expression of fourteen novel obesity-related genes in zucker diabetic fatty rats
... male Zucker diabetic fatty (ZDF) rats (fa/fa) and six male Zucker lean rats (fa/-) (ZL) were studied from an age of 13 weeks until an age of 24 ...
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Deciphering bacterial community changes in zucker diabetic fatty rats based on 16S rRNA gene sequences analysis
... The aim of the present pilot study was deciphering bacterial community changes in Zucker diabetic fatty rats (ZDF rats), a model of type 2 diabetes. Recent studies unmasked that the status of ...
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Effects on Fat Distribution by Food Restriction in Zucker Diabetic Fatty Rats
... The Zucker diabetic fatty (ZDF) rats, derived from inbreeding of hyperglycemic Zucker obese rats, does have marked hyperglycemia along with insulin resistance, hyperlipidemia, and obesity, ...
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Eplerenone prevents salt-induced vascular stiffness in Zucker diabetic fatty rats: a preliminary report
... The renin-angiotensin-aldosterone system (RAAS) plays a key role in the pathophysiology of hypertension and vascular complications of diabetes mellitus. The minera- locorticoid aldosterone is a well established target in ...
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Intrarenal Oxidative Stress and Augmented Angiotensinogen are Precedent to Renal Injury in Zucker Diabetic Fatty Rats
... The Zucker diabetic fatty (ZDF) rat is a model of type II diabetes and metabolic syndrome based on impaired glucose tolerance caused by the inherited insulin-resistance ...
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Antidiabetic treatment restores adiponectin serum levels and APPL1 expression, but does not improve adiponectin-induced vasodilation and endothelial dysfunction in Zucker diabetic fatty rats
... male Zucker lean (ZL) rats (fa/-) and twenty male Zucker diabetic fatty (ZDF) rats (fa/fa) were studied from an age of 11 weeks until an age of 22 ...
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Diabetic cardiomyopathy in Zucker diabetic fatty rats: the forgotten right ventricle
... Male Zucker diabetic fatty (ZDF) rats (fa/fa; n = 12, Charles River Laboratories Brussels, Belgium) and age- matched Zucker lean control rats (ZL; +/+; n = 10) underwent echocardiography and ...
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Sitagliptin prevents aggravation of endocrine and exocrine pancreatic damage in the Zucker Diabetic Fatty rat - focus on amelioration of metabolic profile and tissue cytoprotective properties
... the diabetic ZDF ...in diabetic db/db rats, as well as the results of vildagliptin in diabetic KK-A y mice, are essentially compat- ible with those observed in this study ...
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Treatment of peripheral diabetic neuropathy in Zucker diabetic fatty (ZDF) rats with cariporide
... on diabetic neuropathy in Type 2 diabetes Zuc- ker diabetic fatty (ZDF) rats and lean controls were treated with cariporide (10 or 20 mg/kg/d), a Na+/H+-exchanger-1 inhibitor, for 4 weeks at 15 weeks ...
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Rosiglitazone reverses endothelial dysfunction but not remodeling of femoral artery in Zucker diabetic fatty rats
... In present study, the endothelium-dependent vasorelax- ation in response to ACh was attenuated and the expres- sion of eNOS down regulated in ZDF rats at 19 weeks of age in comparison to Zucker lean rats. The ...
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Long-term treatment with metformin in the prevention of fatty liver in Zucker diabetic fatty rats
... Considering the important roles of CCO in the pro- cesses of glucose and lipid catabolisms in mitochondria, protein expression level of CCO was analyzed by immu- nofluorescence microscopy. There was a homogeneously weak ...
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Hydroxypropyl methylcellulose, a viscous soluble fiber, reduces insulin resistance and decreases fatty liver in Zucker Diabetic Fatty rats
... increased fatty acid oxidation ...increased fatty acid oxidation, have been shown to reduce liver TAG in both lean and obese rats ...plasma fatty acids (in either the fasted or fed state), in plasma ...
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Metabolic syndrome influences cardiac gene expression pattern at the transcript level in male ZDF rats
... It is well established that metabolic syndrome is a major risk factor for cardiovascular diseases [1-4]. Metabolic syndrome is defined as the coexistence of visceral obesity, dyslipidemia, hyperglycemia, and hypertension ...
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Implication of free fatty acids in thrombin generation and fibrinolysis in vascular inflammation in Zucker rats and evolution with aging
... Short title: Fatty acids in thrombin generation and vascular inflammation in aging.. * These authors contributed equally to this work..[r] ...
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Implication of free fatty acids in thrombin generation and fibrinolysis in vascular inflammation in Zucker rats and evolution with aging
... used diabetic Zucker rats while we used obese Zucker rats that only develop diabetes very late with ...the diabetic Zucker rats of the Shang et ...obese Zucker rats is in favor ...
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Effect of stearidonic acid-enriched soybean oil on fatty acid profile and metabolic parameters in lean and obese Zucker rats
... The incorporation of dietary n3PUFA had no effect on glucose homeostasis in the polygenic OZR rat. However, previous studies have shown improved insulin sensitivity with increased dietary n3PUFA intake in obese and dia- ...
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