[PDF] Top 20 Acid-sensing ion channels: trafficking and synaptic function
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Acid-sensing ion channels: trafficking and synaptic function
... Given the fact that acidosis typically lasts for some time in diseases, the above finding suggests that acidosis contributes to the change in brain plasticity in patho- logical conditions. However, several important ... See full document
13
Amiloride blockable acid sensing ion channels are leading acid sensors expressed in human nociceptors
... VR1) function as acid sensors in vivo within a pathophysiologically relevant pH range (pH ≥ ...ASIC-3 channels (20, ...ASIC channels show an order of magnitude with a higher affinity for ... See full document
7
Acid Sensing Ion Channels (ASICs) in NS20Y cells – potential role in neuronal differentiation
... to synaptic plasticity, learning and memory ...ASIC1a channels are expressed in NS20Y cells and that activation of these channels may play a role in neuronal ... See full document
9
Acid sensing ion channels: potential therapeutic targets for neurologic diseases
... in synaptic plasticity, learning, and sensory ...of synaptic plasti- city, especially the facilitation of N-methyl-D-aspartate (NMDA) receptor activation in long-term potentiation (LTP) of hippocampus ... See full document
8
Structure, function, and pharmacology of acid- sensing ion channels (ASICs): focus on ASIC1a
... A large ECD is not specific to ASICs, but shared by all DEG/ENaC channels, although its size can vary. Homology between different ASICs is larg- est in the second two-thirds of the ECD, whereas some parts of the ... See full document
23
Diarylamidines: high potency inhibitors of acid- sensing ion channels
... Acid-sensing ion channels (ASICs) are proton-gated cation channels that are predominantly expressed in the nervous ...these channels and provide probes for their physiological ... See full document
24
Functional modifications of acid-sensing ion channels by ligand-gated chloride channels
... Glycine receptors are ligand-gated chloride channels that are abundantly expressed in spinal neurons [15]. To determine if activation of glycine receptors modifies ASICs, we recorded ASIC currents from cultured ... See full document
13
Acid-sensing ion channels: dual function proteins for chemo-sensing and mechano-sensing
... able function of ASICs and the dual-function roles of ASIC3 in chemo-sensing and ...ASIC channels in mechano-sensing and related biological func- tions, such as the modulation of ... See full document
14
A modulatory role of ASICs on GABAergic synapses in rat hippocampal cell cultures
... during synaptic vesicle release can activate acid-sensing ion channels (ASICs) both on pre- and postsynaptic ...selective acid-sensing ion ...of ... See full document
12
Expression of acid-sensing ion channels and selection of reference genes in mouse and naked mole rat
... acidic synaptic vesicles into the synaptic cleft and thus protons may act as a neuro- transmitters, with ASIC1a expressed in the postsynaptic membrane contributing to synaptic plasticity ...to ... See full document
12
The role of acid sensing ion channels in epithelial Na+ uptake in adult zebrafish (Danio rerio)
... trout (Dymowska et al., 2014). Previous studies on ASICs in zebrafish have demonstrated their widespread expression in the central and peripheral nervous systems, specifically in brain, retina, intestine and taste buds, ... See full document
8
Investigating Structure Function Relationships in Ion Channels Using Unnatural Amino Acids
... 144 nonribosomal peptide synthesis, and through posttranslational modifications. 4 Common places where nature uses D-amino acids include bacterial cell walls, spider venom, and neurologically active peptides. The ... See full document
345
Ion Channels are Biological Devices, the Valves* of Cells Main Controllers of Biological Function
... Depends Sensitively on Self-organized Structure and their Flexibility Induced Structure is Different in Different Solutions. so[r] ... See full document
57
Single Ion Channels
... isolated by the gigaseal, and then collected and studied by specialized picoammeters (‘patch clamp amplifiers’) widely available commercially: indeed, many thousands of our version of the amplifier (the Axopatch) are in ... See full document
10
Ion Channels are Biological Devices, the Valves* of Cells Main Controllers of Biological Function
... RyR model of Gillespie is best worked out for ~ 120 solutions Selectivity of K Channel is studied in ~1 solution at infinite dilution K channel of Roux has atomic detail but is studied a[r] ... See full document
57
Ion channels expression and function are strongly modified in solid tumors and vascular malformations
... Data reported in Table 3 and in Fig. 1 led us to hypoth- esize that ion channels genes may play a relevant role in cancers as well as in other pathological conditions of altered angiogenesis. To further ... See full document
15
Ion Channels as Devices
... The current through the open channel is determined by the driving forces (i.e., power supply) acting on the channel and by the structure of the channel it- self. The driving forces are the power supply and the structure ... See full document
5
Taurine: the appeal of a safe amino acid for skeletal muscle disorders
... amino acid content in skeletal muscle, with- out any adaptive change in TauT activity; in parallel an increase in force and a greater resistance and recovery after fatigue have been ... See full document
18
Ion Channels in Peripheral Blood Mononuclear Cells – Effect of Culture and Ascorbic Acid.
... and function to tissue macrophages when compared to macrophages obtained by PMA (69) induced differentiation, has not been reported ...the function of proton channels is closely ... See full document
126
Ion channels as insecticide targets
... amino acid at this position had been previously identified as a key determinant of the selectivity of neonicotinoids for insects, over vertebrates (Shimomura et ... See full document
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