[PDF] Top 20 Activation of MDA5 Requires Higher-Order RNA Structures Generated during Virus Infection
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Activation of MDA5 Requires Higher-Order RNA Structures Generated during Virus Infection
... HMW RNA but not dsRNA stimulates MDA5. The associa- tion between MDA5-agonistic activity and recognition by K1, a dsRNA-specific MAb, prompted us to analyze RNA prepara- tions from ... See full document
9
Anatomical and Cellular Requirements for the Activation and Migration of Virus-Specific CD8+ T Cells to the Brain during Theiler's Virus Infection
... of activation and expansion of antiviral T cells in the Theiler’s virus model is supported by findings from Kang et ...Theiler’s virus-infected ...Theiler’s virus infection may occur in ... See full document
8
Activation of the Beta Interferon Promoter by Unnatural Sendai Virus Infection Requires RIG-I and Is Inhibited by Viral C Proteins
...  activation due to virus infection (15, ...trailer RNA actually increases when translation is blocked with cycloheximide ...cellular RNA binding protein of the ELAV family (4), and to ... See full document
11
Early B-Cell Activation after West Nile Virus Infection Requires Alpha/Beta Interferon but Not Antigen Receptor Signaling
... an activation phenotype at day 3, no appreciable increase in antigen-specific B cells oc- ...influenza virus that suggested that innate immune activation inhibits the ability of LN B cells to ... See full document
11
Evaluation of the protective roles of complement activation and T cells during Venezuelan equine encephalitis virus infection
... facilitates infection of nearby cells of the peripheral nervous system ...Following infection of peripheral nerves, VEEV is then thought to disseminate to the CNS via centripetal spread ...the virus ... See full document
207
Long Noncoding RNA ITPRIP-1 Positively Regulates the Innate Immune Response through Promotion of Oligomerization and Activation of MDA5
... B virus (HBV) ...observed during viral infection (24, ...HCV infection remain ...HSV infection leads to the activation of the JAK/STAT pathway and induces ISG production, neither ... See full document
23
Chicken Cells Sense Influenza A Virus Infection through MDA5 and CARDIF Signaling Involving LGP2
... influenza virus (AIV) represents a continuous threat for domestic poultry and humans (7, ...although virus spreading and shedding can be ...sensing virus-specific pathogen-associated molecular ... See full document
13
The Cellular RNA Helicase UAP56 Is Required for Prevention of Double-Stranded RNA Formation during Influenza A Virus Infection
... box RNA helicase UAP56 plays a pivotal role in the efficient transcription/replication of influenza A ...the RNA helicase is required for the nuclear export of a subset of spliced and unspliced viral ... See full document
10
The fate of RNA and RNA binding proteins in Sindbis virus infection
... that RNA has much broader functional and regulatory potential in the cell than ...that RNA could form a complex secondary structure which acted as a catalyst for specific biochemical reactions in the ...of ... See full document
111
Cytokine-Independent Upregulation of MDA5 in Viral Infection
... of MDA5, we transfected K562 cells using an Amaxa nucleo- fection system and ...of MDA5 as measured by qRT-PCR ...of MDA5 by SeV-C results from the activation of IRF3 by virus ...of ... See full document
5
Role of Enteroviral RNA-Dependent RNA Polymerase in Regulation of MDA5-Mediated Beta Interferon Activation
... against RNA virus ...recognize RNA viruses and stimulate type I IFN expres- sion ...that MDA5 is a critical pathogen recognition receptor for activating type I IFN expression in response to ... See full document
13
Sensing and Control of Bluetongue Virus Infection in Epithelial Cells via RIG-I and MDA5 Helicases
... response generated by both T and B cells (20, ...For RNA viruses, dsRNAs and single-stranded RNAs (ssRNAs) present in viral genomes or generated during viral replication are two major ...and ... See full document
11
Activation of the Interferon Induction Cascade by Influenza A Viruses Requires Viral RNA Synthesis and Nuclear Export
... being generated but are undetectable by Western ...influenza virus-infected A549 ...erated during genome replication as the IFN-inducing PAMP produced by influenza virus and even demonstrated ... See full document
11
Arenavirus Infection Induces Discrete Cytosolic Structures for RNA Replication
... negative-sense RNA viruses replicate in the cell cytoplasm and express four ...cytosolic structures involved in arenavirus replication and ...Tacaribe virus or the attenuated Candid#1 strain of Junín ... See full document
11
Widespread activation of antisense transcription of the host genome during herpes simplex virus 1 infection
... plex virus, antisense transcripts were defined on the coverage tracks of the HSV-1-infected 4sU samples using a custom running sum algorithm, followed by extensive ... See full document
19
Activation of the interferon induction cascade by influenza A viruses requires viral RNA synthesis and nuclear export
... viral RNA synthesis is re- quired for activation of the IFN induction cascade by influenza ...viral RNA synthesis could be detected in the presence of these ...by RNA viruses did not require ... See full document
12
Early Innate Recognition of Herpes Simplex Virus in Human Primary Macrophages Is Mediated via the MDA5/MAVS-Dependent and MDA5/MAVS/RNA Polymerase III-Independent Pathways
... HSV infection. A recent paper suggests that RNA Pol III recognizes HSV-1 infection and HSV-1 DNA in murine macrophage-like RAW ...whether RNA Pol III recognizes HSV-1 infection in human ... See full document
9
RNA Editing in Hepatitis Delta Virus Genotype III Requires a Branched Double-Hairpin RNA Structure
... delta virus (HDV), allowing the virus to produce two functionally distinct forms of the sole viral protein, hepatitis delta antigen (HDAg), from the same open reading ...on RNA substrates that are at ... See full document
13
Simian virus 40 prevents activation of M-phase-promoting factor during lytic infection.
... To determine whether the increase in p13sucI-Sepharoseprecipitated HI kinase activity seen in the infected culture at 10 h post-mimosine release was due to MPF activity of uninfected mit[r] ... See full document
7
Efficiency of processing of viral RNA during the early and late phases of productive infection by polyoma virus.
... But during the late phase, most viral RNA, even after long labeling periods, remains in the nucleus see below; here, use of method A is called for since otherwise leakage of viral RNA fr[r] ... See full document
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