[PDF] Top 20 An Affinity-Enhanced Neutralizing Antibody against the Membrane-Proximal External Region of Human Immunodeficiency Virus Type 1 gp41 Recognizes an Epitope between Those of 2F5 and 4E10
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An Affinity-Enhanced Neutralizing Antibody against the Membrane-Proximal External Region of Human Immunodeficiency Virus Type 1 gp41 Recognizes an Epitope between Those of 2F5 and 4E10
... The membrane-proximal external region (MPER) of human immunodeficiency virus type 1 (HIV-1) gp41 bears the epitopes of two broadly ... See full document
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Stable Docking of Neutralizing Human Immunodeficiency Virus Type 1 gp41 Membrane-Proximal External Region Monoclonal Antibodies 2F5 and 4E10 Is Dependent on the Membrane Immersion Depth of Their Epitope Regions
... of neutralizing antibodies 2F5 and 4E10 to human immunodeficiency virus type 1 (HIV-1) gp41 involves both the viral membrane and gp41 ... See full document
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Utilization of Immunoglobulin G Fc Receptors by Human Immunodeficiency Virus Type 1: a Specific Role for Antibodies against the Membrane-Proximal External Region of gp41
... constant region of immunoglobulin G (IgG) are an important link between humoral immunity and cellular ...of human immunode- ficiency virus type 1 (HIV-1) immune complexes, ... See full document
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Neutralizing Epitopes in the Membrane-Proximal External Region of HIV-1 gp41 Are Influenced by the Transmembrane Domain and the Plasma Membrane
... Abs against the ...influenza virus HA1 do- main fused to the full sequence of HIV-1 gp41, including its TM and ...a virus-like particle (VLP) or expressed by a DNA vaccine, elicited ... See full document
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4E10-Resistant Variants in a Human Immunodeficiency Virus Type 1 Subtype C-Infected Individual with an Anti-Membrane-Proximal External Region-Neutralizing Antibody Response
... broadly neutralizing monoclonal antibody (MAb) 4E10 recognizes a linear epitope in the C terminus of the membrane-proximal external region (MPER) of ...This ... See full document
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In Vivo gp41 Antibodies Targeting the 2F5 Monoclonal Antibody Epitope Mediate Human Immunodeficiency Virus Type 1 Neutralization Breadth
... broadly neutralizing antibodies, like the membrane-proximal external region (MPER) monoclonal an- tibodies (MAbs) 2F5 and 4E10, is a major goal for antibody- based ... See full document
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Anti-Human Immunodeficiency Virus Type 1 (HIV-1) Antibodies 2F5 and 4E10 Require Surprisingly Few Crucial Residues in the Membrane-Proximal External Region of Glycoprotein gp41 To Neutralize HIV-1
... to 2F5 and 4E10 was only acquired by Ala substitutions to D664, K665, or W666, in the case of 2F5 and W672, F673, or W680 for ...of virus, the sequence of the flanking residues is not nearly ... See full document
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Broad Neutralization of Human Immunodeficiency Virus Type 1 Mediated by Plasma Antibodies against the gp41 Membrane Proximal External Region
... hinge region of the MPER (21, 31, ...the 4E10 MAb. In contrast to MAb 2F5, which seldom neutralizes subtype C viruses due to a subtype-associated polymorphism at position 665 (4, 9), the residue at ... See full document
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Cross-Reactive Human Immunodeficiency Virus Type 1-Neutralizing Human Monoclonal Antibody That Recognizes a Novel Conformational Epitope on gp41 and Lacks Reactivity against Self-Antigens
... cross-reactive human immunodeficiency virus (HIV)-neutralizing antibodies are infrequently elic- ited in infected ...best-characterized gp41-specific cross-reactive neutralizing ... See full document
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Binding of Anti-Membrane-Proximal gp41 Monoclonal Antibodies to CD4-Liganded and -Unliganded Human Immunodeficiency Virus Type 1 and Simian Immunodeficiency Virus Virions
... broadly neutralizing monoclonal antibodies (MAbs) 4E10, 2F5, and Z13e1 target membrane-proximal external region (MPER) epitopes of HIV-1 gp41 in a manner ... See full document
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Broadly Neutralizing Antibodies Targeted to the Membrane-Proximal External Region of Human Immunodeficiency Virus Type 1 Glycoprotein gp41
... broad neutralizing activity of 4E10 against primary isolates of HIV-1 from subtypes A, B, C, D, and ...that 2F5 is a potent and broadly neutralizing MAb, the collected results on ... See full document
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Broadly Neutralizing Monoclonal Antibodies 2F5 and 4E10 Directed against the Human Immunodeficiency Virus Type 1 gp41 Membrane-Proximal External Region Protect against Mucosal Challenge by Simian-Human Immunodeficiency Virus SHIVBa-L
... directed against an access-restricted epitope between and over- lapping the epitopes of 2F5 and ...MAbs 2F5 and 4E10 were originally obtained as IgG3 antibodies in hybrid- omas ... See full document
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Neutralization Efficiency Is Greatly Enhanced by Bivalent Binding of an Antibody to Epitopes in the V4 Region and the Membrane-Proximal External Region within One Trimer of Human Immunodeficiency Virus Type 1 Glycoproteins
... or 1 g of MAb ...each virus stock in a single-round entry ...of antibody-treated viruses was measured using a single-round entry assay and is presented as a percentage of the infectivity of the ... See full document
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The Broadly Neutralizing Anti-Human Immunodeficiency Virus Type 1 Antibody 2G12 Recognizes a Cluster of α1→2 Mannose Residues on the Outer Face of gp120
... broadly neutralizing MAbs to HIV-1 were known (5, ...which recognizes an epitope overlapping the CD4 recep- tor site (7, 51), and 2G12, which recognizes an epitope based around ... See full document
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Importance of the Membrane-Perturbing Properties of the Membrane-Proximal External Region of Human Immunodeficiency Virus Type 1 gp41 to Viral Fusion
... interactions between Env and the assembling Gag ...this region, allowing the MPER to inter- act instead with the membrane through its tryptophan resi- dues, which in turn could alter the ability of ... See full document
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A neutralizing monoclonal antibody previously mapped exclusively on human immunodeficiency virus type 1 gp41 recognizes an epitope in p17 sharing the core sequence IEEE.
... of human immu- nodeficiency virus type 1 (HIV-1) transmission and replication is the identification and characterization of epitopes which can induce neutralizing antibodies ... See full document
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Llama Antibody Fragments with Cross-Subtype Human Immunodeficiency Virus Type 1 (HIV-1)-Neutralizing Properties and High Affinity for HIV-1 gp120
... broadly neutralizing MAb 2G12, which recognizes a carbohy- drate motif on gp120 (9, 70, 72, 80), the anti-V3 MAb 447-52D, which neutralizes primary isolates of subtype B (30, 31), and MAb 17b, which ... See full document
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A Conserved Tryptophan-Rich Motif in the Membrane-Proximal Region of the Human Immunodeficiency Virus Type 1 gp41 Ectodomain Is Important for Env-Mediated Fusion and Virus Infectivity
... the human immunodeficiency virus type 1 (HIV-1) transmembrane envelope glycoprotein, gp41, within a region immediately adjacent to the membrane-spanning ... See full document
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Human Immunodeficiency Virus Type 1 gp41 Antibodies That Mask Membrane Proximal Region Epitopes: Antibody Binding Kinetics, Induction, and Potential for Regulation in Acute Infection
... induce neutralizing 2F5-like or 4E10- like antibodies in mice could be due to lack of a native gp41 prefusion or intermediate conformation of the MPER (28), lack of a lipid component of the ... See full document
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Crystallographic Definition of the Epitope Promiscuity of the Broadly Neutralizing Anti-Human Immunodeficiency Virus Type 1 Antibody 2F5: Vaccine Design Implications
... a human immunodeficiency virus type 1 (HIV-1) vaccine capable of eliciting broadly neutralizing antibodies against Env has been ...The ... See full document
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