[PDF] Top 20 Allergen immunotherapy for allergic rhinoconjunctivitis: protocol for a systematic review

... Quality assessments will independently be carried out on each study by two reviewers using the relevant ver- sion of the Critical Appraisal Skills Programme (CASP) quality assessment tool for systematic reviews ... See full document

... of allergic asthma, allergic rhino conjunctivitis, food allergy and venom allergy, and allergy prevention, which will be used to inform the formulation of key clinical rec- ...this review is on ... See full document

... and systematic reviews, and RCTs and case series with a minimum of 300 patients will be used to assess ...as systematic reviews and/or meta-analyses of RCTs, together with individual ... See full document

... the systematic review; U. Nurmatov: support to undertake the review; Giovanni Pajno: none; Montserrat Fernandez‑Rivas: Participation in immunotherapy clinical trials sponsored by ALK‑Abello; ... See full document

... published systematic review hide the underlying heterogeneity between ...published systematic reviews have struggled to deliver useful subgroup analyses, mainly due to heterogeneity in study ... See full document

... This review of a very substantial body of international trial evidence, many of which were judged to be at low ROB, has found clear evidence that AIT improved all three of our primary outcomes – ... See full document

... rush protocol to 2 days as well as increasing the initial dose of venom ...rush protocol is safe and the risk of systemic reactions is rare when the num- ber of injections administered is reduced from 20 ... See full document

... the review, during the conduct of the study; A Kakourou: has nothing to disclose; F Asamoah: reports payment from Evidence-Based Health Care Ltd during the conduct of the study; I Agache: consulting fee for ALK ... See full document

... Abstract: Allergic rhinitis is a common health problem in both children and ...patients allergic to ragweed (Ambrosia artemisiifolia) is on the rise throughout Europe, having a significant negative impact ... See full document

... Clinical trial data on allergoid compounds published before March 2012 was retrieved from a meta-analysis performed by Di Bona et al. [17] (Table 1). In addition, the PubMed-database was searched to identify random- ized ... See full document

... for allergic rhinoconjunctivitis was recently reviewed according to the Appraisal of Guidelines for Research and Evaluation (AGREE II) approach and resulted in a guideline document published by the European ... See full document

... treat allergic disease. A recent review of 11 case reports of anaphyl- axis (all non-fatal) found that none corresponded to standard practice in SLIT [24]; in fact, the events in- volved non-standardized ... See full document

... For SCIT, local reactions, including urticaria, swelling, and redness or pain at the injection site, occurred in 0% to 27% of trial patients in the treatment arm or 6.4 events per patient. In the comparator arms, such ... See full document

... of allergen, clinical efficacy and the adminis- tration ...in Allergen-Specific Im- munotherapy [73], twelve reported a dose-response rela- tionship for clinical ...for allergen extracts required by ... See full document

... A further three reviews undertook a qualitative syn- thesis of the impact of AIT on asthma symptom scores. Erekosima et al. [14] reported on 10 studies [19–28], including 628 participants, that evaluated SCIT for con- ... See full document

... c immunotherapy (SIT) is frequently used to treat asthma and allergic rhinitis and may modify the course of the ...and allergic rhinitis symptoms cannot be adequately controlled with medication or ... See full document

... epicutaneous allergen-specific immunotherapy with grass- pollen allergens in patients with allergic ...grass allergen or placebo, and after tape- stripping each patch was applied for 48 hours ... See full document

... Methods/Design: We will include randomised clinical trials irrespective of publication date, publication type, publication language, and publication status investigating infusions with immunoglobulins in relation to ... See full document

... but allergen avoidance is difficult with pollens, necessitating the use of pharmacotherapy ...pharmacotherapy, immunotherapy targets the immunologic cause of re- spiratory symptoms and is the only treatment ... See full document

... The statistical analysis was performed using Statistica software, version 8.12 (SoftPol, Cracow, Poland). The Intent-to-treat (ITT) included all randomized patients. The modified ITT population included all randomised ... See full document