[PDF] Top 20 Alpha Interferon Inhibits Hepatitis C Virus Replication in Primary Human Hepatocytes Infected In Vitro
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Alpha Interferon Inhibits Hepatitis C Virus Replication in Primary Human Hepatocytes Infected In Vitro
... Real-time PCR quantification of positive- and negative-strand HCV RNA. Both positive- and negative-strand HCV RNAs were quantified by means of a real-time PCR assay using the LightCycler instrument and technology (Roche ... See full document
11
Hepatitis C Virus Infection Induces the Beta Interferon Signaling Pathway in Immortalized Human Hepatocytes
... Hepatitis C virus (HCV) infection is the major cause of chronic liver disease, cirrhosis, and hepatocellular ...pegylated alpha interferon (IFN- ␣ ) in com- bination with ...infecting ... See full document
7
Hepatitis C Virus Induces Epithelial-Mesenchymal Transition in Primary Human Hepatocytes
... Hepatitis C virus (HCV)-mediated liver disease progression may reflect distinct molecular mechanisms for increased hepatocyte growth and hepatic stellate cell ...that primary human ... See full document
8
Primary Human Hepatocytes Are Susceptible to Infection by Hepatitis Delta Virus Assembled with Envelope Proteins of Woodchuck Hepatitis Virus
... into primary hepatocytes, we made use of a panel of six pep- tides bearing pre-S sequences, with three derived from HBV L and three from WHV L, as summarized in Table ...the virus for binding of the ... See full document
8
Identification of Alpha Interferon-Induced Envelope Mutations of Hepatitis C Virus In Vitro Associated with Increased Viral Fitness and Interferon Resistance
... in primary escape cultures com- pared to cell cultures infected with recombinants with engineered resistance ...that interferon-stimulated genes (ISG), MxA, ISG15, protein kinase R (PKR), and ... See full document
18
Woodchuck Gamma Interferon Upregulates Major Histocompatibility Complex Class I Transcription but Is Unable To Deplete Woodchuck Hepatitis Virus Replication Intermediates and RNAs in Persistently Infected Woodchuck Primary Hepatocytes
... 100% it reached confluence. After the culture medium was discarded, 100 l of F-12 medium containing appropriate dilutions of samples containing wIFN-␥ was added to the cells for an additional incubation of 24 h. ... See full document
10
Elimination of hepatitis C virus RNA in infected human hepatocytes by adenovirus-mediated expression of ribozymes.
... for hepatitis C infection has been hindered by the inability to grow the virus in culture and the lack of an animal model other than the chimpanzee ...and replication of viral genomic ...from ... See full document
10
Serum-Derived Hepatitis C Virus Infection of Primary Human Hepatocytes Is Tetraspanin CD81 Dependent
... infect primary human hepatocytes as revealed here by the intracel- lular accumulation of both genomic and replicative strands (not ...mary hepatocytes, it has to be noted that less than 15% of ... See full document
6
Modeling Subgenomic Hepatitis C Virus RNA Kinetics during Treatment with Alpha Interferon
... HCV replication from transfection to steady state (6); however, similarly detailed modeling of other HCV genotypes and comparison of their IFN- ␣ inhibition kinetics might reveal the basis of the distinct IFN- ␣ ... See full document
8
Exosome-Mediated Intercellular Communication between Hepatitis C Virus-Infected Hepatocytes and Hepatic Stellate Cells
... or primary human hepatic stellate cells after exposure to HCV-exo showed a myofibroblast like appearance with increased expres- sion of ␣ -SMA and enhanced expression of profibrogenic ...RNA ... See full document
15
Human MxB Inhibits the Replication of Hepatitis C Virus
... MxB inhibits RNA replication of ...then infected with JFH1 HCVcc (MOI ⫽ ...in infected cells were quantified by ...newly infected cells at 72 ...in vitro-synthesized JFH1 mRNA or ... See full document
18
Hepatitis C Virus Infection Impairs IRF-7 Translocation and Alpha Interferon Synthesis in Immortalized Human Hepatocytes
... I interferon response by inducing expression of IFN- ␣ , which also acts in both autocrine and paracrine manners through the IFN- ␣ /  ...the virus, as HCV infection failed to translocate IRF-7 and inhibit ... See full document
8
Promotion of Cancer Stem-Like Cell Properties in Hepatitis C Virus-Infected Hepatocytes
... that hepatitis C virus (HCV) infection of primary human hepatocytes (PHH) induces the epithelial mesenchymal transition (EMT) state and extends hepatocyte life span ...These ... See full document
8
Elimination of Duck Hepatitis B Virus RNA-Containing Capsids in Duck Interferon-Alpha-Treated Hepatocytes
... duck interferon (DuIFN) cDNA encodes a homologue of mammalian interferon-alpha (IFN- a ...duck hepatitis B virus (DHBV) replication in primary hepatocytes in order ... See full document
7
Recombinant Duck Interferon Gamma Inhibits Duck Hepatitis B Virus Replication in Primary Hepatocytes
... hepadnavirus replication in infected ...DuIFN-g inhibits DHBV replication after initial conver- sion of the rcDNA of the infecting virus into cccDNA but before the appearance of progeny ... See full document
7
Evolution of the Hepatitis C Virus Second Envelope Protein Hypervariable Region in Chronically Infected Patients Receiving Alpha Interferon Therapy
... Hepatitis C virus (HCV) is a small, enveloped, positive- stranded RNA virus belonging to the Flaviviridae family ...titis C is usually paucisymptomatic, but about 20% of patients have ... See full document
10
Hepatitis C virus in vitro replication is efficiently inhibited by acridone Fac4
... Lawitz, E., Lalezari, J. P., Hassanein, T., Kowdley, K. V., Poordad, F. F., Sheikh, A. M., Afdhal, N. H., Bernstein, D. E., Dejesus, E., Freilich, B., Nelson, D. R., Dieterich, D. T., Jacobson, I. M., Jensen, D., Abrams, ... See full document
29
Genomic responses to hepatitis B virus (HBV) infection in primary human hepatocytes
... Cultured primary human hepatocytes (PHH) are the closest in vitro model to human liver and constitute a very predictive model for pharmaco-toxicology in vivo ... See full document
15
Spatiotemporal Analysis of Hepatitis B Virus X Protein in Primary Human Hepatocytes
... then infected, transduced, or transfected on the following ...of primary antibodies were ...BSA. Primary and secondary antibodies were applied for 90 min and 60 min, ... See full document
16
MicroRNA-27a Regulates Lipid Metabolism and Inhibits Hepatitis C Virus Replication in Human Hepatoma Cells
... factor C/EBP ␣ . (A) Induction of miR-27a and C/EBP ␣ expression by oleic acid and HCV ...and C/EBP ␣ (right) levels were quantified by RTD-PCR (n ⫽ ...and C/EBP ␣ expression by ...and ... See full document
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