[PDF] Top 20 Analysis of Epstein-Barr Virus Genomes and Expression Profiles in Gastric Adenocarcinoma

... tree analysis showed that most GC isolates are most closely related to NPC isolates; however, there was a strong geographical or/and ethnic component in that few American Caucasian EBV isolates were part of this ... See full document

... human Epstein-Barr virus (EBV)-associated gastric carcinoma (EBVaGC), established in severe combined immunodeficiency (SCID) mice, with which the cytokine expression of EBVaGC can be ... See full document

... protein expression in EBV+ gastric cancers in relation to ...negative gastric cancers (2 microsatellite instable (MSI), 3 genomic instable (GS), 5 chromosomal instable (CIN)) that were part of a ... See full document

... RNA containing a 3= hydroxyl group characteristic of miRNAs. In total, eight libraries were sequenced, two libraries from the paren- tal AGS cell line, two libraries from the original AGS-EBV cell line, and one library ... See full document

... 1) gastric cancer specific, 2) indicative of inflam- mation, and/or 3) predictive of response to specific med- ...that gastric cancer early detection strat- egies or monitoring tests could be tailored to ... See full document

... Statistical analysis A chi-square test, Fisher’s exact test or Kruskal Wallis test was used for statistical analysis of the IHC results and clinicopathologic ...the expression of mRNA or proteins was ... See full document

... ABSTRACT Epstein-Barr virus (EBV) is one of the major oncogenic viruses and is found in nearly 10% of gastric ...the expression of 44 known EBV miRNAs in tissue samples from patients ... See full document

... early gastric carcinogenesis and tumor originated from the monoclonal growth of EBV infected cells ...the gastric body or cardia region at gastric ...tubular adenocarcinoma or poorly ... See full document

... The Epstein–Barr virus (EBV) is associated with a variety of cancers, including gastric cancer, which has one of the highest mortality rates of all human ...non-EBV-infected gastric ... See full document

... Gene expression patterns were examined in EBV-negative and EBV-positive AGS gastric epithelial cells using a low density microarray, reverse transcription PCR, histochemical stains, and methylation-specific ... See full document

... differentiated adenocarcinoma was ac- companied by a dense infiltration of ...cytokine expression of carcinoma cells, since the contribution of infiltrating lymphocytes can be neglected in the assay of ... See full document

... the expression of two main target genes in the cross network were further ...binding, gastric acid secretion, etc. Pathway analysis showed that the differentially expressed genes were mainly enriched ... See full document

... of gastric carcinomas (GC) are comprised of cells latently infected with Epstein-Barr virus (EBV); however, the mechanism by which EBV contributes to the development of this malignancy is ... See full document

... gels using labeled HSV-1 polypeptides and unlabeled purified proteins of known molecular weight as standards. Symbols: *, position of the HSVpolypeptides; 0, position of unlabeled protei[r] ... See full document

... the lytic virus cycle (9), these BamHI-H and -B1 transcripts in nontreated Akata cells are likely to be lytic-cycle RNAs by spontaneous virus induction.. It is reported that the cell lin[r] ... See full document

... The inability to amplify EBV sequences from 1 tg of PBMN DNA from normal seropositive patients suggests that the detection of EBV sequences in the normal LG results from cells containing[r] ... See full document

... cytokine profiles and our flow cytometry approach may be useful in follow-up of patients with ...the profiles of anti-inflammatory mediators among EBV-HLH, EBV-IM, and FHL were largely similar to the ... See full document

... the binding of the major viral envelope glycoprotein gp350/220 to the CR2 (CD21) receptor on the surface of B cells. Since 17 epithelial cells lack the CR2 receptor, the virus-encoded fusion proteins, gB and gH/gL ... See full document

... Keywords: Epstein–Barr virus, Gastric remnant carcinoma, Clinicopathologic characteristics, Genotypes, EBV associated GRC © The Author(s) ... See full document

... Conclusions In conclusion, we have identified 5 distinct subtypes of BRLF1 in Northern Chinese EBV isolates in multiple clinical specimens. The subtype BR1-C is more frequent in NPCs, while BR1-A preferentially presents ... See full document