[PDF] Top 20 Analysis of pramipexole dose–response relationships in Parkinson's disease

... maintenance dose, PD stage, combined levodopa dose, and baseline tremor ...Parkinson’s Disease Rating Scale (UPDRS II+III) was used as a covariate for final score ... See full document

... age, disease duration, disease severity) (Supplementary ...Patients’ disease severity according to Hoehn and Yahr staging generally fell at stages I or II, with only a minor proportion of patients ... See full document

... an analysis conducted of data collected from 2 groups of patients enrolled in parallel long-term tolerability and efficacy studies of tolcapone and entacapone (Factor et al ...this analysis, tolcapone was ... See full document

... observed 16 weeks after surgery, suggesting that they were still releasing dopamine in the surrounding striatal tissue. Although the residual content of dopamine in the implants was not determined, its possible presence ... See full document

... Materials and methods: Three patients with PD and three normal controls were enrolled in the present study from July 12, 2017, to August 29, 2017. RNA sequencing and bioinformatics analy- sis were performed to obtain ... See full document

... linkage analysis and genome-wide association studies, but also new methods, like meta-analysis of genome- wide association studies, gene–gene and gene–environment interaction studies, pathway ... See full document

... The search results revealed a total of 214 articles (Figure 1). After the duplicates were removed, the titles were screened for evidence of a yoga intervention in persons with PD. The available abstracts for 43 articles ... See full document

... enced pain that a patient feels extends over a continuum from no pain to an extreme intensity of pain. This range of perceived pain appears continuous for the patient. Pain does not appear as an ordinary scale with jumps ... See full document

... (CSF) analysis of amyloid beta peptide 1–42 (A β 42), tau and phosphorylated ...postmortem analysis of brain histopathology showing dif- fuse neuronal and synaptic loss with extracellular amyloid plaques of ... See full document

... receive pramipexole ER (0.26–3.15 [0.375–4.5] mg qd), pramipexole IR ...primary analysis. At 18 weeks an interim analysis on a subset of 253 patients was planned to evaluate superiority of ... See full document

... it has been demonstrated that ( − )-sesamin from Asiasarum heterotropoides F. Maekawa var. mandshuricum, and GPS and the ethanol extract from G. pentaphyllum have neuroprotective effects on the l -DOPA-induced memory ... See full document

... Parkinson’s disease (PD) and provide an overview of the current pharmacological management strategies, with a specific focus on ...Parkinson’s Disease Rating Scale motor ...amide dose of 70 mg/day ... See full document

... An early symptom for dementia is usually mild forgetfulness which later advances into other cognitive abilities and memory to an extent where the patient is no longer capable of being independent. 12 14 Common symptoms ... See full document

... notes regarding clonazepam. First, in patients with gait insta- bility, clonazepam can cause greater gait instability at night. Patients note this problem especially when they have to use the bathroom at night, and must ... See full document

... Parkinson’s disease (PD) is one of the most frequent neurological ...the disease management often complicated even when the presence of PD seems ...the disease, especially with the progressive effect ... See full document

... neurodegenerative disease such as Parkinson’s disease, multiple system atrophy, and Alzheimer’s ...Parkinson’s disease, and provide an update on prevalence, pathophysiology, clinical manifestation, ... See full document

... supportive relationships between those with PD, their caregivers, and other loved ones; and 3) dance is enjoyable and motivating, possibly promoting long-term, consistent ... See full document

... point to the likelihood of synergistic interactions between endogenous and exogenous NSCs after transplantation. They reported that endogenous NSCs proximal to the graft expressed SHH, which possibly contributed to the ... See full document

... Parkinson’s disease and there is limited evidence regarding treatment of this ...Parkinson’s disease, including symptoms, epidemiology, diagnosis, and treatment, with a focus on the patient’s ... See full document

... drug (eg, efficacy for symptomatic control of parkinsonism/ prevention of motor complications, safety, practicality, costs), to the patient (eg, symptoms, age, needs, expec- tations, experience, comorbidity, ... See full document