[PDF] Top 20 Analysis of the role of the Hippo pathway in cancer
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Analysis of the role of the Hippo pathway in cancer
... the Hippo pathway plays an essential role in most of cancers, which makes it to be a critical field for further ...the hippo pathway is the opportunities and challenges to the treatment ... See full document
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The Role of Hippo Pathway in Mitosis and Cancer
... a role in metaphase-anaphase transition through interactions with Aurora-B and BubR1 at kinetochores ...important role of Ajuba in mitosis, and indicate that Ajuba may exert its oncogenic or tumor ... See full document
104
The role of Hippo signal pathway in breast cancer metastasis
... the HIPPO signaling pathway The Hippo signaling pathway is present ubiquitously in mammals, and its activity is strictly ...regulated. Hippo pathway activation is triggered by ... See full document
9
The Hippo pathway in colorectal cancer
... possible role of the Hippo pathway in the Wnt-related patho- mechanisms of the CRC ...Wnt pathway (Figure ...of Hippo pathway kinase cassette [95]. Moreover, WB protein ... See full document
15
The Hippo pathway in normal development and cancer
... prostate cancer (PC) in mice (Nguyen et ...YAP analysis in tissue samples, conveying the message that increased YAP activity may represent a mechanism conferring resistance to androgen- deprivation therapy ... See full document
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The Hippo pathway in disease and therapy: cancer and beyond
... The Hippo tumour suppressor pathway co-ordinates cell proliferation, cell death and cell differentiation to regulate tissue growth ...core Hippo signalling module receives signal inputs on different ... See full document
12
The role of the Hippo pathway in human disease and tumorigenesis
... human cancer is essential to the development of effective and personalized ...The Hippo signaling pathway has been demonstrated to play a central role in the regulation of tissue and organ ... See full document
10
Comprehensive molecular characterization of the hippo signaling pathway in cancer
... of Hippo Pathway Regulatory Networks We obtained DNA methylation data (450k, 27k) from Genome Data ...each Hippo pathway gene, we first selected the probe with the most significant negative ... See full document
21
Upregulation of miR-181c contributes to chemoresistance in pancreatic cancer by inactivating the Hippo signaling pathway
... pancreatic cancer pathogenesis, we examined miR-181c expression in pancreatic cancer samples and found that miR-181c was markedly upregulated in pancreatic cancer tissues as compared to normal ... See full document
14
A novel Yap/Taz zebrafish reporter reveals a role of Hippo pathway transducers in angiogenesis
... Statistical analysis were carried out with Prism software (GraphPad). 3.16 Assessment of vascular changes The defective ISVs sprouting angiogenesis in Tg(kdrl:GFP) Yap/Taz double morphants was evaluated at 32 hpf. ... See full document
112
Histone Acetylation-Mediated Regulation of the Hippo Pathway
... The Hippo pathway is a signaling cascade recently found to play a key role in tumorigenesis therefore understanding the mechanisms that regulate it should open new opportunities for cancer ... See full document
12
TFAP2C promotes stemness and chemotherapeutic resistance in colorectal cancer via inactivating hippo signaling pathway
... the Hippo pathway constitutes of four core kin- ase cassette components, including kinases MST1/2 and LATS1/2, as well as the adaptor proteins SAV1 and MOB1 ...The Hippo signaling is active via ... See full document
16
CRABP2 regulates invasion and metastasis of breast cancer through hippo pathway dependent on ER status
... pancreatic cancer cell invasion and metastasis by stabilizing the interleukin 8 expressions ...of cancer cells ...breast cancer. CRABP2 prevents the growth of breast cancer cells by two ... See full document
18
The Hippo/YAP pathway interacts with EGFR signaling and HPV oncoproteins to regulate cervical cancer progression
... prostate cancer (Overholtzer et al, 2006; Zender et al, 2006; Dong et al, 2007; Yuan et al, 2008; Zhang et al, 2009; Hall et al, 2010; Jemal et al, 2011; Hergovich, 2012; He et al, ...liver cancer, YAP has ... See full document
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Circ_0001667 promotes breast cancer cell proliferation and survival via Hippo signal pathway by regulating TAZ
... Bioinformatics analysis, an emerging discipline, was useful for the biologist to explore the underlying mech- anism and interrelation of ...bioinformatics analysis and the result demonstrated that ... See full document
10
Germline polymorphisms in genes involved in the Hippo pathway as recurrence biomarkers in stage II/III colon cancer
... Interestingly, Hippo signaling has been implicated in resistance to 5-Fu in CRC cell lines as YAP overexpression has been shown to lead to cellular quiescence and chemoresistance 15 ...the Hippo signaling ... See full document
22
Potential Role of Hippo Signaling Pathway in Gastric Cancer
... The Hippo signaling pathway has been demonstrated to play a central role in the development and regulation of tissues and organ ...of Hippo signaling leads to a concurrent combination of ... See full document
7
The Hippo Signaling Pathway in Development and Cancer
... Baena-Lopez, L.A., Rodrı´guez, I., and Baonza, A. (2008). The tumor suppressor genes dachsous and fat modulate different signalling pathways by regulating dally and dally-like. Proc. Natl. Acad. Sci. USA 105, 9645–9650. ... See full document
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Role of TRIP6 and Angiomotins in the Regulation of the Hippo Signaling Pathway
... as Hippo (Hpo), is a core kinase of the Hippo signaling ...the Hippo signaling network (such as myc, crumbs, ex, merlin, four-jointed, and kibra) to eventually inactivate itself through a negative ... See full document
124
A Putative Dual Role for Yorkie in Hippo pathway Signaling
... Canonical Hippo pathway Signaling Normal Hippo pathway functioning occurs via specific signals, leading to a cascade of events, via proteins, within the cell (Figure ...the Hippo ... See full document
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