[PDF] Top 20 Anti-interleukin-5 therapy in severe asthma
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Anti-interleukin-5 therapy in severe asthma
... that anti-IL-5 therapies are biologically active and significantly reduce blood and sputum eosinophils and symptomatic exacerbations in patients with severe ...with severe asthma and ... See full document
7
Role of biologics in severe eosinophilic asthma – focus on reslizumab
... for anti-IL-5 biotherapies requires a careful pheno- typic stratification based on reliable clinical, functional, and biologic ...nonallergic asthma, also experiencing recurrent disease exacerbations ... See full document
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Profile of anti-IL-5 mAb mepolizumab in the treatment of severe refractory asthma and hypereosinophilic diseases
... recurrent severe asthma exacerbations and signs of eosinophilic inflamma- ...of asthma exacerbations in patients with severe eosinophilic asthma compared with ...and Asthma ... See full document
10
Omalizumab in children with severe allergic disease: a case series
... Although anti-IgE therapy was prolonged for a total of 48 weeks, milk desensitization ...combined therapy, the patient experienced a mild-to-moderate adverse reaction slowing escalation of the milk ... See full document
11
Serum interleukin-5 levels are elevated in mild and moderate persistent asthma irrespective of regular inhaled glucocorticoid therapy
... persistent asthma could have contrib- uted to airway smooth muscle hyper responsiveness and airway ...of asthma. In this regard administration of antibodies against IL-5 [21,22] or IL-5 ... See full document
6
Tailored therapy for severe asthma
... In asthma, the response against aeroallergens is mainly based on the inflammatory response of T lymphocytes, with an important involvement of IL-1β in the inflamma- tory signal ...allergic asthma patients, ... See full document
8
Severe eosinophilic asthma: from the pathogenic role of interleukin-5 to the therapeutic action of mepolizumab
... lowered asthma exacerbations and improved QoL and symptom ...adjunctive therapy iN patients with Severe Asthma) study was conducted by Ortega et al, who recruited 576 subjects with ... See full document
8
Dermatomyositis associated with omalizumab therapy for severe asthma: a case report
... Case presentation: We present a case of a 59-year old female who developed amyopathic dermatomyositis (DM) after receiving omalizumab infusions for steroid-refractory severe asthma. After 6 months of ... See full document
5
The Soluble Tumor Necrosis Factor Alpha Receptor Suppresses Airway Inflammation in a Murine Model of Acute Asthma
... in asthma patients. This study investigated whether TNF- α blocking therapy inhibits airway inflammation and airway hyperresponsiveness (AHR) in a mouse model of ...blocking therapy on cytokine ... See full document
7
Omalizumab and mepolizumab in the landscape of biological therapy for severe asthma in children: how to choose?
... other anti-IL-5 drugs are not to be used in patients with parasitic infestations, given the fundamen- tal role that this cytokine plays in the immune response against such ...mepolizumab therapy, ... See full document
9
Severe Asthma With Fungal Sensitization in a Child: Response to Itraconazole Therapy
... aggressive therapy, our group felt that it was prudent to initi- ate treatment with close ...to therapy was the re- turn of symptoms and elevation of se- rum IgE level after discontinuation of ...allergens. ... See full document
6
Expression of mRNA for interleukin 5 in mucosal bronchial biopsies from asthma
... hybridization signals for IL-5 mRNA were demonstrated within the bronchial mucosa in 6 out of the 10 asthmatic subjects. Cells exhibiting hybridization signals were located beneath the epithelial basement ... See full document
7
Omalizumab: an anti-immunoglobulin E antibody for the treatment of allergic respiratory diseases
... the anti-allergic and anti- inflammatory properties of omalizumab in a study where a significant increase in eosinophil apoptosis and a decline in interleukin (IL)-2 + and IL-13 + T-lymphocytes was ... See full document
9
Anti-IL-5 therapy in patients with severe eosinophilic asthma – clinical efficacy and possible criteria for treatment response
... from anti-IL-5 ther- apy but whether the statement “the higher the better” is true is not universally agreed ...of anti-IL-5 therapy, little conclusion can be drawn from eosinophils ... See full document
9
Benralizumab, an add-on treatment for severe eosinophilic asthma: evaluation of exacerbations, emergency department visits, lung function, and oral corticosteroid use
... of severe eosinophilic asthma by targeting a subunit of the IL-5 ...this therapy has an adequate safety profile, and this was confirmed in later ...improving asthma symptoms and quality ... See full document
10
Benralizumab: a unique IL-5 inhibitor for severe asthma
... one severe COPD exacerbations requiring treatment or hospitalization in the past year, treat- ment with double or triple therapy throughout the year before enrollment, and a history of ... See full document
11
Airway autoimmune responses in severe eosinophilic asthma following low-dose Mepolizumab therapy
... Background: Anti-interleukin (IL)-5 monoclonal antibodies as an eosinophil-depleting strategy is well established, with Mepolizumab being the first biologic approved as an adjunct treatment for ... See full document
6
Anti interleukin 13 and anti interleukin 4 agents versus placebo, anti interleukin 5 or anti immunoglobulin E agents, for children and adults with asthma
... of interleukin-13 (Chomorat 1998). In particular, interleukin-4 plays an important role in maintaining the TH phenotype, lead- ing to further secretion of interleukin-4 and -13 in a positive feed- ... See full document
13
Targeted therapy in severe asthma today: focus on immunoglobulin E
... Abstract: Asthma is a complex chronic inflammatory disease of multifactorial ...for asthma, which has the potential to guide treatment ...many asthma phenotypes, allergic asthma represents the ... See full document
9
Role of zinc in severe pneumonia: a randomized double bind placebo controlled study
... of severe pneumonia, pneumonia, duration of hospital stay, nil per oral, intravenous fluid, oxygen use, treatment requiring 2 nd line of drug and 3 rd line drug were evaluated and found to be ... See full document
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