[PDF] Top 20 HIV-1 Antibody Neutralization Breadth Is Associated with Enhanced HIV-Specific CD4+ T Cell Responses
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HIV-1 Antibody Neutralization Breadth Is Associated with Enhanced HIV-Specific CD4+ T Cell Responses
... Antigen-specific CD4 ⴙ T helper cell responses have long been recognized to be a critical component of effective vaccine immu- ...nity. CD4 ⴙ T cells are necessary to ... See full document
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HIV 1 immunogens and strategies to drive antibody responses towards neutralization breadth
... of HIV-1 and focus the antibody response on conserved sites, such as the CD4bs and fusion pep- ...B cell precursors with the right specificities can be activated in ...bNAb responses ... See full document
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Fine epitope signature of antibody neutralization breadth at the HIV-1 envelope CD4-binding site
... both HIV-1 vaccines and antiviral antibody ...the antibody responses being raised by novel vaccine candidates may serve a critical role in vaccine research and ...other antibody ... See full document
15
Enhanced Anti-HIV Functional Activity Associated with Gag-Specific CD8 T-Cell Responses
... to enhanced antiviral function in vitro, CD8 T cells from high Gag responders displayed an overall more polyfunctional cytokine profile upon stimulation with HIV peptide pools, with significantly ... See full document
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The Neutralization Breadth of HIV-1 Develops Incrementally over Four Years and Is Associated with CD4+ T Cell Decline and High Viral Load during Acute Infection
... in HIV-1 infection remains ...factors associated with the pres- ence of broadly cross-neutralizing antibodies, which develop in a subset of chronically HIV-1-infected ... See full document
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Induction of Gag-Specific CD4 T Cell Responses during Acute HIV Infection Is Associated with Improved Viral Control
... that HIV-specific T cells responding to different antigens may have divergent functional ...Env-specific T cells may be more critical to support neutral- izing antibody ... See full document
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HIV-1 Env- and Vpu-Specific Antibody-Dependent Cellular Cytotoxicity Responses Associated with Elite Control of HIV
... of HIV-specific antibodies to Fc ␥RIIIa is a relatively novel approach to studying functional antibodies for HIV, having previously been used to study influenza virus-specific antibodies ...of ... See full document
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Human adenovirus specific T cells modulate HIV specific T cell responses to an Ad5 vectored HIV 1 vaccine
... 4 HIV Research Section, San Francisco Department of Public Health, San Francisco, California, ...reduce T cell responses to the insert antigens; however, the impact of vector-specific ... See full document
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Differential Neutralization of Human Immunodeficiency Virus (HIV) Replication in Autologous CD4 T Cells by HIV-Specific Cytotoxic T Lymphocytes
... CD8 T cells of differing specificities derived from the same person to inhibit virus in infected autologous CD4 T ...CD8 T-cell responses in a functional assay that measures the ... See full document
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Antibodies to the CD4-binding site of HIV-1 gp120 suppress gp120-specific CD4 T cell response while enhancing antibody response
... between CD4 T cell and Ab responses to envelope was rather surprising, these find- ings are consistent with recent studies on chronic lym- phocytic choriomeningitis virus (LCMV) infection in ... See full document
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Enhanced Recognition and Neutralization of HIV-1 by Antibody-Derived CCR5-Mimetic Peptide Variants
... and CD4-Ig raises the possibility that a CCR5-mimetic peptide such a CCR5mim2 might increase the therapeutic utility of ...essary breadth, CD4-Ig has been disappointing therapeutically be- cause it ... See full document
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Strong Human Endogenous Retrovirus-Specific T Cell Responses Are Associated with Control of HIV-1 in Chronic Infection
... and HIV-1-negative ...are associated with protection from HIV-1 disease progression (HLA-B27 and -B57) constituted a large proportion of the subjects with the strongest HERV ... See full document
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Comparison of Antibody-Dependent Cell-Mediated Cytotoxicity and Virus Neutralization by HIV-1 Env-Specific Monoclonal Antibodies
... of HIV-1 NL4-3 - ver- sus HIV-1 JR-FL -infected cells to ADCC illustrates the importance of using primary virus isolates for studying antiviral functions of ...immune responses, the ... See full document
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Influence of Novel CD4 Binding-Defective HIV-1 Envelope Glycoprotein Immunogens on Neutralizing Antibody and T-Cell Responses in Nonhuman Primates
... HxBc2 neutralization in animals that exhibited the highest neutralization titers against this ...the neutralization of HxBc2 ...of neutralization IC 50 s for the adsorbed fractions were used ... See full document
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Early Preservation of CXCR5+ PD-1+ Helper T Cells and B Cell Activation Predict the Breadth of Neutralizing Antibody Responses in Chronic HIV-1 Infection
... ⫹ CD4 ⫹ T cells has been identified in the periphery (35, ...⫹ CD4 ⫹ T cells are inherently linked ...⫹ CD4 ⫹ T cells are involved in the development of broadly neutralizing ... See full document
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Antibody Conjugation Approach Enhances Breadth and Potency of Neutralization of Anti-HIV-1 Antibodies and CD4-IgG
... circulating HIV-1 isolates. In this study, the neutralization abilities of PG9 and PG16 were further enhanced by bioconjugation with aplaviroc, a small-molecule inhibitor of virus entry into ... See full document
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HIV-1-Specific Interleukin-21+ CD4+ T Cell Responses Contribute to Durable Viral Control through the Modulation of HIV-Specific CD8+ T Cell Function
... of HIV-1-specific CD4 ⫹ T cells to improve the antiviral efficacy of HIV-1-specific CD8 ⫹ T cells via IL-21 signaling is a central part of ... See full document
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The role of follicular helper CD4 T cells in the development of HIV 1 specific broadly neutralizing antibody responses
... Tfh cell induction and optimal antigen-specific Tfh- B cell interaction will most likely necessitate a combination of more than one ...Tfh cell induction, function and memory are also ...Table ... See full document
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HIV-1 Epitope Variability Is Associated with T Cell Receptor Repertoire Instability and Breadth
... International HIV Controllers Study, Pereyra F, Jia X, McLaren PJ, Telenti A, de Bakker PI, Walker BD, Ripke S, Brumme CJ, Pulit SL, Carrington M, Kadie CM, Carlson JM, Heckerman D, Graham RR, Plenge RM, Deeks SG, ... See full document
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CD4+ CD25+ Regulatory T Cells Impair HIV-1-Specific CD4 T Cell Responses by Upregulating Interleukin-10 Production in Monocytes
... in HIV-1-associated immune impairment and high- light the need for a better understanding of the HIV-1-induced alterations of these cellular ...restore T cell function in ... See full document
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