[PDF] Top 20 APRIL modulates B and T cell immunity
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APRIL modulates B and T cell immunity
... in APRIL Tg mice (6, ...recombinant APRIL leads to B cell accumulation in the spleen, resulting in increased spleen weight (18), supports this ...of APRIL protein may not be physio- ... See full document
13
Absence of Donor Specific Anti HLA Antibodies After ABO Incompatible Heart Transplantation in Infancy: Altered Immunity or Age?
... develop B-cell tolerance to donor ABO antigens as previously described, but were found in this study also to show reduced development of antibodies specific for class II HLA, including ... See full document
8
Asymmetric T Cell Division and the Self-renewal of Specific Immunity
... unequal T-bet mRNA expression (Lighvani et ...in T-bet amounts in the daughter ...dividing cell to asymmetrically apportion T-bet to its daughter cells? Our findings suggest that the tyrosine ... See full document
107
MicroRNA-146a modulates B-cell oncogenesis by regulating Egr1
... In an effort to further characterize tumorigenesis in these mice, we undertook gene expression analysis by high-throughput sequencing. We have found that a small set of genes are significantly differentially regulated ... See full document
15
Enhanced mucosal and systemic immune responses to intestinal reovirus infection in beta2-microglobulin-deficient mice.
... mucosal immunity to an enteric pathogen, we examined immune responses and viral clearance following enteric reovirus infection in C57BL/6, B6129F2, and b 2-microglobulin-deficient ( b 2m 2 / 2 ) ... See full document
8
Hexokinase 2 is dispensable for T cell-dependent immunity
... RNA quality and quantity were measured using Agilent 4200 TapeStation using High Sensitivity RNA ScreenTape System (Agilent Technologies). SMART-Seq v4 Ultra Low Input RNA Kit (Takara Bio USA, Inc.) was used to gener- ... See full document
18
KLRG1 restricts memory T cell antitumor immunity
... restricted T cell antitumor immunity by the following five aspects: 1) poor proliferative capacity, 2) diminished production of effector cytokines, 3) elevated production of pro-inflammatory ... See full document
9
The role of virus-specific T cell immunity in the pathogenesis of acute and chronic Hepatitis B virus infection
... Hepatitis B core antigen (HBcAg) self-assembles in the hepatocytes cytoplasm to form nucleocapsid particles, that package pregenomic RNA and viral ...host immunity by preferentially eliciting a Th2 profile ... See full document
165
CD4 T-Cell-Mediated Heterologous Immunity between Mycobacteria and Poxviruses
... CD4 T cells, but the small variations in responses between BCG-immune versus sham-immune mice seemed no different than the variations occurring within either of the ...by T cells infiltrating the visceral ... See full document
12
The role of the ICOS B7h T cell costimulatory pathway in transplantation immunity
... according to either the early- or delayed-treatment pro- tocols described above. Ten days after transplantation, the draining lymph nodes were removed and stained with anti–CD4-PerCP, anti–Vα2.1-FITC and anti–Vβ8.1- ... See full document
11
TNF α is critical for antitumor but not antiviral T cell immunity in mice
... was determined by weekly measurement of blood glucose levels in mice of the indicated genotype. This was used as a surrogate marker of tumor development and immune surveillance, since it is a direct measure of β islet ... See full document
14
Demarcated thresholds of tumor-specific CD8 T cells elicited by MCMV-based vaccine vectors provide robust correlates of protection
... + T cell responses that were > 0.5% of the total CD8 + T cell population at 4 weeks and even up to 13 months after vaccination ...and b). In addition, the E7-specific CD8 + T ... See full document
17
Interleukin-35 on B cell and T cell induction and regulation
... induce T cell proliferation and foster IFN-γ production in p35- deficient mice, P40 deficient mice, and wild-type mice, thus eliminating the ...anti-fungal immunity [43]. The CD4 + T cells in ... See full document
7
Coinfection with Streptococcus pneumoniae Modulates the B Cell Response to Influenza Virus
... Although PR8⫹Sp coinfection leads to overall increased PR8- specific serum IgG, including HA-specific IgG, serum HI Abs were not increased. This could be due to a lack of sensitivity of the HI assay. Additional ... See full document
11
DENTAL CARIES AND LACTOBACILLUS: ROLE AND ECOLOGY IN THE ORAL CAVITY
... . Cell Surface Hydrophobicity: Attachment of Lactobacillus to the tissues or tooth surface is the first step for biofilm formation where the cell surface hydrophobicity greatly modulates the ... See full document
12
Autoantigen, innate immunity, and T cells cooperate to break B cell tolerance during bacterial infection
... LN B cells in RF Tg infected mice compared with uninfected ...mice. B. burgdorferi infection is associated with B cell activation and IgM ...RF B cells appear specially sensitive to ... See full document
12
Immune recognition of self in immunity against cancer
... T cell–dependent immunity against mutated self antigens on tumors Can cancer cells with mutated self peptides stimulate host T cells? As few as two or three distinct mutations in different ... See full document
5
Virus-Specific T-Cell Immunity Correlates with Control of GB Virus B Infection in Marmosets
... HCV immunity is the common marmoset (Callithrix ...(MHC)-restricted T-cell im- ...virus B (GBV-B) (4, 19), but there have been re- ported cases of persistent infection with similar ... See full document
7
mTOR Promotes Antiviral Humoral Immunity by Differentially Regulating CD4 Helper T Cell and B Cell Responses
... CD8 T cells can promote memory T cell differentiation in response to infection and vaccination (10, ...dendritic cell- or CD8 T cell-mediated immunity during ...protective ... See full document
17
Distinct Roles of Vaccinia Virus NF-κB Inhibitor Proteins A52, B15, and K7 in the Immune Response
... B pathway inhibitors A52, B15, and K7 in immunity, we deleted their genes in an NYVAC (New York vaccinia virus) strain that expresses HIV-1 clade C ...dendritic cell, natural killer cell, ... See full document
14
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