[PDF] Top 20 Two E2 binding sites alone are sufficient to function as the minimal origin of replication of human papillomavirus type 18 DNA.
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Two E2 binding sites alone are sufficient to function as the minimal origin of replication of human papillomavirus type 18 DNA.
... contain two E2BS (pori127 contains two high-affinity E2BS, while pori117* contains one low-affinity and one high-affinity site), these results suggest that replication of HPV-18 ori DNA ... See full document
5
DNA Replication of Human Papillomavirus Type 31 Is Modulated by Elements of the Upstream Regulatory Region That Lie 5′ of the Minimal Origin
... the replication activities of HPV31 genomes that contain a deletion of the KE or a neutral DNA spacer are comparable and below wt levels suggests that the KE element may contain sequences that directly ... See full document
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cis-Acting components of human papillomavirus (HPV) DNA replication: linker substitution analysis of the HPV type 11 origin.
... abolish replication. The promiscuity of E1 in replication has also been demonstrated in a cell-free system in which origin-independent replication occurs at high concen- trations of BPV-1 E1 ... See full document
10
Role of the ATP-Binding Domain of the Human Papillomavirus Type 11 E1 Helicase in E2-Dependent Binding to the Origin
... the E2-dependent binding of E1 to the origin and that this stimu- lation can be abolished by substitutions in the E1 DNA-binding ...upon binding ATP-Mg, the E1 C-terminal domain ... See full document
12
Targeted mutagenesis of the human papillomavirus type 16 E2 transactivation domain reveals separable transcriptional activation and DNA replication functions.
... hinge-DNA binding region of E2 ...least two path- ways of transactivation by the E2 protein: one was the classical transactivation activity mediated by the N-terminal domain, and the ... See full document
10
Conditional Mutations in the Mitotic Chromosome Binding Function of the Bovine Papillomavirus Type 1 E2 Protein
... the E2-TA protein is also critical for E2’s function in DNA replication, interaction with the E1 protein, and transcriptional ...the E2 protein, and it appears to be extremely ... See full document
10
p53 represses human papillomavirus type 16 DNA replication via the viral E2 protein
... HPV E2 protein plays an important role in viral repli- cation and in the regulation of HPV gene expression ...[15]. E2 binds to four sites within the HPV LCR and via a pro- tein-protein interaction, ... See full document
9
E1 recognition sequences in the bovine papillomavirus type 1 origin of DNA replication: interaction between half sites of the inverted repeats.
... bovine papillomavirus type 1 (BPV-1) is required for viral DNA replication, and it binds site specifically to an A/T-rich palindromic sequence within the viral origin of ...and ... See full document
10
Bovine papillomavirus type 1 DNA replication: the transcriptional activator E2 acts in vitro as a specificity factor.
... BPV1 DNA fragment (nucleotides [nt] 7855 to 81 in the viral genomic sequence [6]) carrying what was defined as a minimal origin for BPV1 DNA replication (55) together with an adjacent ... See full document
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Human TATA Binding Protein Inhibits Human Papillomavirus Type 11 DNA Replication by Antagonizing E1-E2 Protein Complex Formation on the Viral Origin of Replication
... HPV-11 E2 purification. Full-length HPV-11 E2 was purified as described previously (4) with these ...Briefly, E2 was expressed in Escherichia coli BL21(DE3) and purified using heparin-agarose and ... See full document
10
Two E2 binding sites (E2BS) alone or one E2BS plus an A/T-rich region are minimal requirements for the replication of the human papillomavirus type 11 origin.
... To investigate the effect on replication of the position of the E2BS relative to the spacer, we compared the replication activities of plasmids containing a number of E2BS located at dif[r] ... See full document
9
Dose-dependent regulation of the early promoter of human papillomavirus type 18 by the viral E2 protein.
... of E2, which may be more difficult in transient transfection ...four E2 binding sites) contains the entire HPV18 LCR (positions 6929 to 120), with the CAT ORF under control of the P105 ... See full document
9
Novel Binding Sites for Regulatory Factors in the Human Papillomavirus Type 18 Enhancer and Promoter Identified by In Vivo Footprinting
... the two most proximal top strand G’s in these same E2 sites, and these guanines showed equiv- alent reactivity to DMS in vivo and in vitro ...of E2 sites, clear protections in vivo of ... See full document
9
The Human Papillomavirus Type 16 E6 Gene Alone Is Sufficient To Induce Carcinomas in Transgenic Animals
... E6 alone is sufficient to induce tumors in vivo, mice from each K14E6 transgenic lineage were moni- tored closely for tumorigenesis over their life ...The two lines with high copy numbers of the E6 ... See full document
7
Intracellular localization and DNA-binding properties of human papillomavirus type 18 E6 protein expressed with a baculovirus vector.
... In mammalian cells, BPV-1 E6 protein is localized in equal proportions to both the nucleus and nonnuclear membranes 2, whereas the majority of cottontail rabbit papillomavirus CRPV E6 lo[r] ... See full document
9
Recruitment of Brd4 to the Human Papillomavirus Type 16 DNA Replication Complex Is Essential for Replication of Viral DNA
... cycle, E2 binds to its binding sites in HPV16 ...E1 binding to the viral Ori and recruits cellular replication factors to the viral DNA replication complex ...and ... See full document
14
Phosphorylation Regulates Binding of the Human Papillomavirus Type 8 E2 Protein to Host Chromosomes
... cells, two pop- ulations of E2-associated pericentromeric foci are observed on mitotic ...UBF-positive E2 foci that colocalize with UBF at the rDNA loci on acrocentric ...The E2-associated ... See full document
12
Dynamic Localization of the Human Papillomavirus Type 11 Origin Binding Protein E2 through Mitosis While in Association with the Spindle Apparatus
... BPV-1 E2 protein, Brd4 colocalizes with E2 and forms distinct foci on the mitotic chromosomes (4, ...HPV-11 E2 protein relative to Brd4 through mitosis, we generated a GFP fusion construct of Brd4 ... See full document
9
Replication of bovine papillomavirus type 1 DNA initiates within an E2-responsive enhancer element.
... The patterns detected show that bovine papillomavirus type 1 replicates in these cells bidirectionally and that one replication origin site in the viral genome is utilized.. By employing[r] ... See full document
9
The Carboxyl-Terminal Region of the Human Papillomavirus Type 16 E1 Protein Determines E2 Protein Specificity during DNA Replication
... relative replication activities of wild-type and hybrid HPV E1 ...minimize replication differences that might be attributable to mRNA translation efficiencies, the 59 untranslated sequence and first ... See full document
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