[PDF] Top 20 BRCA1 and BRCA2 mutations in a population based study of male breast cancer
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BRCA1 and BRCA2 mutations in a population based study of male breast cancer
... A study combining linkage and mutation data in multiple case families has estimated the sensitivity of the most commonly used mutation detection techniques for these genes to be approximately 70% ...[23]. ... See full document
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BRCA2 Mutations in 154 Finnish Male Breast Cancer Patients
... CHEK2-Breast Cancer Consor- tium MR (2002). Low-penetrance susceptibility to breast cancer due to CHEK2(*)1100delC in noncarriers of BRCA1 or BRCA2 ... See full document
5
Cancer prevalence in 129 breast-ovarian cancer families tested for BRCA1 and BRCA2 mutations
... a male breast cancer phenotype in addition to female breast cancer, where 76% linked to BRCA2 and only a small percentage to ...familial breast cancer have been ... See full document
5
CiteSeerX — BRCA1 and BRCA2 Mutation Status and Tumor Characteristics in Male Breast
... for BRCA1/BRCA2 germ-line mu- tations and that had a priori mutation probability <10% showed loss of heterozygosity at all three of the intragenic BRCA2 markers analyzed, which could be related to ... See full document
7
Population testing for cancer predisposing BRCA1/BRCA2 mutations
... general population. Our study is limited by being specific to the Jewish community and, hence, our find- ings on uptake, psychological impact, and quality-of-life cannot be directly extrapolated/applied to ... See full document
11
The importance of BRCA1 and BRCA2 genes mutations in breast cancer development
... both BRCA1 and BRCA2 ...both BRCA1 and BRCA2 ...a study conducted by Merge et ...35 mutations have mutations in ex- on 11 of BRCA1 gene primarily ...considered ... See full document
12
Recurrent mutations of BRCA1, BRCA2 and PALB2 in the population of breast and ovarian cancer patients in Southern Poland
... Conclusions Based on the results presented above and data from pre- vious studies we conclude that (i) the “standard panel” of five BRCA1 founder mutations, described published previously by ... See full document
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Prevalance of BRCA1 and BRCA2 mutations in familial breast cancer patients in Lebanon
... to study BRCA1/2 mutation spectra in the Lebanese population, 72 unrelated patients with a reported family history of breast and/or ovarian cancers or with an early onset breast ... See full document
7
Analysis of BRCA1 and BRCA2 Mutations in Eastern Egyptian Breast Cancer Patients
... sporadic breast cancer and one hundred healthy first- degree relatives were included in the ...in BRCA1 was expressed at low frequency (3%), whereas the 5382insC in BRCA1 and 6174delT in ... See full document
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BRCA1 mutations in women with familial or early-onset breast cancer and BRCA2 mutations in familial cancer in Estonia
... of cancer in relatives of BRCA1 and BRCA2 mutation carriers We next analyzed the incidence of cancer in relatives of those individuals identified as carrying BRCA1or BRCA2 ...The ... See full document
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Frequency of Mutations in Brca1 and Brca2 Genes in Women with Breast Cancer in Córdoba, Argentina
... of BRCA1 / 2 mutation in subgroups of patients with breast cancer (BC) and ovarian cancer (OC) selected by age, family history and ethnicity has been little researched outside Europe and North ... See full document
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BRCA1 and BRCA2 mutations and clinical interpretation in 398 ovarian cancer patients: comparison with breast cancer variants in a similar population
... Acknowledgements The authors are grateful to all the women who participated in this study. We also want to thank the clinic team for the careful selection and dedication to the patient attention, specially to ... See full document
8
Prevalence of BRCA1 and BRCA2 mutations in unselected breast cancer patients from Medellín, Colombia
... Patient population We conducted a study on unselected breast cancer pa- tients diagnosed at any age from February 2007 to April 2009, recruited from a single large public hospital in Medellin, ... See full document
5
Novel mutations in the BRCA1 and BRCA2 genes in Iranian women with early-onset breast cancer
... the study cohort, we failed to identify a causative mutation, regardless of the presence or absence of a family history and these may simply be sporadic ...in breast cancer risk in the ... See full document
7
Prevalence of BRCA1/BRCA2 mutations in a Brazilian population sample at-risk for hereditary breast cancer and characterization of its genetic ancestry
... This study has some limitations, such as the fact that other high and moderated BC associated genes were not included in the ...Brazilian study involving complete sequencing of the genes ... See full document
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High frequency of pathogenic non-founder germline mutations in BRCA1 and BRCA2 in families with breast and ovarian cancer in a founder population
... EMBRACE Study, Douglas F, Brady A, Cook J, Tischkowitz M, Adlard J, Barwell J, Ong KR, Walker L, Izatt L, Side LE, Kennedy MJ, Rogers MT, Porteous ME, Morrison PJ, Platte R, Eeles R, Davidson R, Hodgson S, Ellis ... See full document
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PIK3CA mutations are frequently observed in BRCAX but not BRCA2 associated male breast cancer
... Further study correlating serum oestradiol, testosterone levels and PIK3CA mutation frequency in MBCs are required to further elaborate on a possible ...in BRCA1/2 deficient cancers), to PARP inhibition by ... See full document
11
Presymptomatic breast cancer in Egypt: role of BRCA1 and BRCA2 tumor suppressor genes mutations detection
... in BRCA1 gene is a frame shift mutation in exon 22 (5454 del ...in BRCA2 gene is the frame shift (5-base deletion) mutation in exon 9 (999 del ...Finnish breast cancer families [39], which may ... See full document
10
Cancers Associated with BRCA1 and BRCA2 Mutations Other Than Breast and Ovarian
... the cancer spectrum associated with BRCA1 and BRCA2 ...This study found an increased incidence in two cancers, other than breast and ovarian, in individuals with a BRCA mutation when ... See full document
25
Study of BRCA2 Gene Mutations in Egyptian Females with Breast Cancer
... this study we assesed the frequency of two founder mutations in BRCA2 gene which are 999del5 and ...This study was carried out on fifty Egyptian females, including twenty healthy females as ... See full document
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