[PDF] Top 20 C–H functionalization for hydrogen isotope exchange
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C–H functionalization for hydrogen isotope exchange
... involving hydrogen isotopes makes their installation an important and continuing challenge to synthetic ...transformation, hydrogen isotope exchange requires a continually evolving preparative ... See full document
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Iridium-catalyzed Csp3-H activation for mild and selective hydrogen isotope exchange
... Catalyzed C−H Bond Functionalizations: Mechanism and ...Metal-Catalyzed C–H Bond Activa- tion. Chem. Soc. Rev. 2011, 40, 4740-4761. (c) Cho, ...Oxidative C–H Bond ... See full document
43
Practically convenient and industrially-aligned methods for iridium-catalysed hydrogen isotope exchange processes
... 6 For examples using iridium catalysis, see: (a) R. H. Crabtree, E. M. Holt, M. Lavin and S. M. Morehouse, Inorg. Chem., 1985, 24, 1986; (b) R. Heys, J. Chem. Soc., Chem. Commun., 1992, 680; (c) J. R. Heys, ... See full document
6
Investigations into the requirements for homogeneous platinum- and iridium-catalyzed oxidative C-H bond functionalization
... degassed and filled with helium. With the stopcock open and connected via a rubber hose to a helium source and a mercury bubbler, the flask was heated to 368 K. Then, 7.0 mL of 6.25 M hydrochloric acid (aq) was injected ... See full document
225
A first example of cobalt catalyzed remote C H functionalization of 8 aminoquinolines operating through a single electron transfer mechanism
... knowledge this work represents the first example of a SET remote functionalization of 8-aminoquinoline using Co. The absence of activity when strong electron-withdrawing groups are present in the substrate ... See full document
9
One carbon oxidative annulations of 1,3 enynes by catalytic C–H functionalization and 1,4 rhodium(III) migration
... allylic hydrogen atoms cis to the alkyne in the 1,3-enyne are important for efficient one-carbon annulation, which in turn provides further support for 1,4-rhodium(III) migration occurring through the intermediacy ... See full document
5
Redox-controlled mechanisms of C and H isotope fractionation between silicate melt and COH fluid in the Earth’s interior
... A description and discussion of how carbon and hydrogen isotopes fractionate between fluids and melts at high temperature and pressure and with variable redox condi- tions is the focus of this presentation. Most ... See full document
17
The synthesis of highly active iridium(I) complexes and their application in catalytic hydrogen isotope exchange
... aryl C-H bond, requires a moderate activation enthalpy of ...subsequent H/D exchange step (13 → 17) is calculated to be rapid, with an activation barrier of ...such H/D exchange ... See full document
12
Expanded applicability of iridum(I) NHC-phosphine catalysts in hydrogen isotope exchange processes with pharmaceutically-relevant heterocycles
... The water inlet for the carousel reflux system was turned on prior to any further reaction set up. To a carousel tube was added the substrate of choice (0.086 mmol, unless otherwise stated) and iridium(I) catalyst ... See full document
8
Bipolar carbon and hydrogen isotope constraints on the Holocene methane budget
... Figure 3. Data and inversion. The panels on the left (a–c) show the concentration and the two stable isotope signatures of CH 4 measured in ice cores representing the tropospheric values over the Holocene. ... See full document
21
Hydrogen water isotope exchange in a trickle bed column by process simulation and 3D computational fluid dynamics modelling
... Randomly packed beds are utilized in majority of industrially operated trickle bed reactors due to their simplicity in construction and loading process. From a phenomenological perspective, the structure of solid ... See full document
208
Mechanistic Insights into Alkane C H Activation and Functionalization by Metal Oxide Surfaces and Organometallic Complexes
... n-butane C-H bonds remain ...by hydrogen abstraction from one of the methylene of n-butane by this superoxo species to form a surface bound hydroperoxy and a alkyl radical, which is quickly captured ... See full document
206
Hydrogen isotope exchange with highly active iridium(I) NHC/phosphine complexes : a comparative counter-ion study
... The exchange of hydrogen in a C-H bond by deuterium or tritium, through the process of hydrogen isotope exchange (HIE), represents a direct and economical method of ... See full document
5
Cp*Ir(III)-Catalyzed Isoquinolone Synthesis via C-H Activation and Functionalization of Benzamides.
... benzamide derivatives (1) with alkyne substrates (2). The catalytic system proved not only effective for the conversion of diphenylacetylene, but also for a variety of arylaryl-, or unsymmetrical phenylalkyl- ... See full document
195
Continuous-flow isotope ratio mass spectrometry method for carbon and hydrogen isotope measurements on atmospheric methane
... Fig. 1. Scheme of the online methane analysis system: methane from the sample air stored in the sample loop is isolated from other air components by subsequent preconcentration, cryofocussing and gas chromatographic ... See full document
15
The development and use of novel iridium complexes as catalysts for ortho-directed hydrogen isotope exchange reactions
... such exchange processes far in excess of the industry standard, Crabtree’s catalyst, with excellent levels of labelling being achieved over short reaction times (< 90 min) and at very low metal complex loadings ... See full document
13
Catalytic C–H Bond Functionalization by Nickel(0) N-Heterocyclic Carbene Complexes: Influence of Ligand Sterics on Selective Silylation
... of C–H silylation, and instead gives alkene hydroarylation, as previously ...the C–H bond functionalization reaction led to several key insights, the most surprising being that the β-Si ... See full document
127
Site-selective deuteration of N-heterocycles via iridium-catalyzed hydrogen isotope exchange
... (16) For a review of transition-metal-catalyzed C−H activation of indoles, see: (a) Beck, E. M.; Gaunt, M. J. Top. Curr. Chem. 2010, 292, 85−121. (b) Sandtorv, A. H. Adv. Synth. Catal. 2015, 357, ... See full document
5
Iridium(I)-catalyzed regioselective C[BOND]H activation and hydrogen-isotope exchange of non-aromatic unsaturated functionality
... and hydrogen isotope exchange, we looked to further explore the capabilities of our developed system by extending the substrate scope (Table ...key C-H activation ... See full document
5
Contra-thermodynamic hydrogen atom abstraction in the selective C−H functionalization of trialkylamine N‑CH3 groups
... site-selective functionalization of tertiary ...for C − H activation remote from the nitrogen of a tertiary ...radical hydrogen atom transfer (HAT) to site-selective functionalization ... See full document
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