[PDF] Top 20 CD8+ T cell selection, function, and death in the primary immune response in vivo
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CD8+ T cell selection, function, and death in the primary immune response in vivo
... analyze T-cell selection during the devel- opment of memory by comparing the composition of in vivo “primary” and “memory” populations of T cells specific for a given epitope in ... See full document
12
Apoptosis in T-Lymphocyte Subsets in Human Immunodeficiency Virus-Infected Children Measured Immediately Ex Vivo and following In Vitro Activation
... in immune category ...lymphocyte death may predominantly occur in locations other than the peripheral ...of cell death in the CD8 population than in the CD4 population ...(22). ... See full document
5
An affinity/avidity model of peripheral T cell regulation
... essential function of the immune system is to mount effec- tive immune responses to virtually any foreign antigens but avoid harmful immune responses to ...developing T cells maintain ... See full document
12
Severe Symptomatic Primary Human Cytomegalovirus Infection despite Effective Innate and Adaptive Immune Responses
... an immune escape mechanism ...uncontrolled immune responses limiting the effectiveness of specific mounted ...and T lymphocytes, which is thought to be a primary mediator of tissue ...delayed ... See full document
19
Estimating In Vivo Death Rates of Targets due to CD8 T-Cell-Mediated Killing
... of CD8 T cells in vivo and adds several improvements to the previous analysis (7, 37, ...the immune response to ...GP33-specific CD8 T-cell response by ... See full document
9
Exploiting knowledge of immune selection in HIV-1 to detect HIV-specific CD8 T-cell responses
... viral T-cell epitopes and responses to date; however, responses against variant or subdominant epitopes may be missed using these approaches ...potential T-cell epitopes (PTEs), toggled ... See full document
12
Primary CD8+ T-Cell Response to Soluble Ovalbumin Is Improved by Chloroquine Treatment In Vivo
... memory CD8 ⴙ T ...memory T cells. The magnitude of a secondary im- mune response correlates with the size of memory T cells induced by the cross-presented antigen during priming (28, ... See full document
8
The effect of aging and caloric restriction on murine CD8+ T cell chemokine receptor gene expression
... chemokine function may therefore have signif- icant impact on both the normal and pathological inflam- matory responses in the ...in vivo multicomponent physiological and pathological responses ...system. ... See full document
10
Unexpected positive control of NFκB and miR-155 by DGKα and ζ ensures effector and memory CD8 T cell differentiation
... enhanced CD8 cell function, particularly during primary ...(CAR)-transduced T cell- mediated antitumor immunity in mice [28, 56, ...boost T cell activation and ... See full document
21
A Journey in Science: “Not Lost in Translation”
... numerous immune response genes, including Lck, CD28, CD4, and CD8 ...a cell to survive and proliferate or trigger its programmed ...for cell survival be- cause engagement of this ... See full document
5
Specific Mutation of a Gammaherpesvirus-Expressed Antigen in Response to CD8 T Cell Selection In Vivo
... in response to immune ...cytotoxic T lymphocytes (CTLs) developed progressive disease and ...lymphoblastoid cell lines (LCL) carrying these EBV ...in response to host CTL ... See full document
7
Exposure to wild type AAV drives distinct capsid immunity profiles in humans
... and T cells has been shown to at least partially address the issue ...humoral immune responses to AAV vectors with direct clinical ...adaptive immune responses to both the capsid (15) and the ... See full document
14
Antitumor adaptive immunity remains intact following inhibition of autophagy and antimalarial treatment
... tumor cell autophagy promotes T cell infiltration and activation in response to anthracycline ...the immune modulatory effects of tumor cell autophagy following ...impact ... See full document
14
Dynamics of Tissue-Specific CD8+ T Cell Responses during West Nile Virus Infection
... 9. Lanteri MC, Diamond MS, Law JP, Chew GM, Wu S, Inglis HC, Wong D, Busch MP, Norris PJ, Ndhlovu LC. 2014. Increased frequency of Tim-3 expressing T cells is associated with symptomatic West Nile virus infec- ... See full document
16
The 14th International Conference on Human Retrovirology: HTLV and related retroviruses (July 1–4, 2009; Salvador, Brazil)
... Kuan-Teh Jeang (Bethesda, USA) outlined that Tax expres- sion induced micronuclei resulting from trapping of chro- mosomes by nuclear envelope reformation after telophase. Jeang reported that chromosome missegrega- tion ... See full document
8
Lectin of Concanavalin A as an anti-hepatoma therapeutic agent
... of cell death is responsible for a popula- tion of tumor ...Tumor cell lines use autophagy to recycle essential metabolites such as lipids and amino acids for fuelling the bioenergetic machinery in ... See full document
12
Immunotherapy with an HIV-DNA Vaccine in Children and Adults
... In the clinical context, new therapeutic approaches, such as HIV vaccines, have been investigated in recent years in both children and adults [1,7–11]. The goal of immune intervention in HIV infection is to ... See full document
19
CD80 and CD86 Control Antiviral CD8+ T-Cell Function and Immune Surveillance of Murine Gammaherpesvirus 68
... virus-specific CD8 ⫹ T cells often offers in- sights into their functional status (25, ...virus-specific CD8 ⫹ T cells, their phenotypes dif- fered significantly in CD28 ⫺/⫺ and CD80/CD86 ⫺/⫺ ... See full document
12
Borna Disease Virus Nucleoprotein (p40) Is a Major Target for CD8+-T-Cell-Mediated Immune Response
... cytotoxic T lymphocytes (CTL), we made use of the following different vaccinia virus (VV)-BDV recombinants, each ex- pressing only one BDV-specific protein: VV-BDV p40 (VV- p40), VV-BDV p24 (VV-p24), VV-BDV gp18 ... See full document
6
Physiology of anergic CD8 T cells in a transgenic mouse model
... activate T cells, as only som e “p rofessional” APC like DC can trigger both the TCR and the T cell co-stim ulatory ...induces T cell responsiveness and differentiation to effector ... See full document
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