[PDF] Top 20 Characterization of Hepatitis C Virus E2 Glycoprotein Interaction with a Putative Cellular Receptor, CD81
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Characterization of Hepatitis C Virus E2 Glycoprotein Interaction with a Putative Cellular Receptor, CD81
... HCV E2 gp bound to the surface of the T-cell line Molt-4 and that this interaction could be inhibited both by a MAb specific for the hypervariable region (HVR) and by HCV-infected chimpanzee sera ...ecule ... See full document
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Human Monoclonal Antibodies That Inhibit Binding of Hepatitis C Virus E2 Protein to CD81 and Recognize Conserved Conformational Epitopes
... the E2 antibodies isolated from this HCV PCR-positive B-cell donor could inhibit the interaction of E2 with CD81 raises an important ...that CD81 is not the primary receptor for ... See full document
10
Identification of Conserved Residues in the E2 Envelope Glycoprotein of the Hepatitis C Virus That Are Critical for CD81 Binding
... Hepatitis C virus (HCV) cell entry involves interaction between the viral envelope glycoprotein E2 and the cell surface receptor ...conserved E2 determinants ... See full document
10
Binding of Hepatitis C Virus E2 Glycoprotein to CD81 Does Not Correlate with Species Permissiveness to Infection
... Hepatitis C virus (HCV) glycoprotein E2 binds to human cells by interacting with the CD81 molecule, which has been proposed to be the viral ...to CD81 and species ... See full document
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Role of Conserved E2 Residue W420 in Receptor Binding and Hepatitis C Virus Infection
... Hepatitis C virus (HCV) enters cells via interactions with several host factors, a key one being that between the viral E2 envelope glycoprotein and the CD81 ...identified ... See full document
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Hepatitis C Virus E2-CD81 Interaction Induces Hypermutation of the Immunoglobulin Gene in B Cells
... many cellular genes, including immunoglob- ulin (Ig) and p53 genes in B cells ...to CD81 may activate AID and other enzymes through the receptor-mediated signal transduction ...of E2 to ... See full document
11
Immunogenic and Functional Organization of Hepatitis C Virus (HCV) Glycoprotein E2 on Infectious HCV Virions
... in E2 glycosylation with HCVpp and HCVcc affecting the surface exposure of their ...with CD81, a putative HCV receptor ...and C (CBH-7) antibodies blocked recombinant E2 protein ... See full document
5
Functional Characterization of Intracellular and Secreted Forms of a Truncated Hepatitis C Virus E2 Glycoprotein
... If CD81 is the primary receptor for HCV, our observations imply that the aggregated form of E2 may not be incorporated into HCV ...when E2 is expressed in several cell lines and with several ... See full document
8
Mutations within a Conserved Region of the Hepatitis C Virus E2 Glycoprotein That Influence Virus-Receptor Interactions and Sensitivity to Neutralizing Antibodies
... to CD81, we tested the reactivity of the intracellular viral glyco- proteins to ...mutant E2 in Huh-7 cells transfected with appropriate viral RNAs was first normalized by measuring their binding to the ... See full document
14
Binding of the Hepatitis C Virus E2 Glycoprotein to CD81 Is Strain Specific and Is Modulated by a Complex Interplay between Hypervariable Regions 1 and 2
... and characterization of in- teractions between viral and host cell ...surface CD81 molecule is a putative HCV receptor component and devising of in vitro and ex vivo assays to measure ... See full document
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Hepatitis C Virus Envelope Glycoprotein E2 Glycans Modulate Entry, CD81 Binding, and Neutralization
... Hepatitis C virus (HCV) is a major human pathogen that causes serious liver disease, including cirrhosis and hepatocellular ...and E2, with cellular receptors. E1 and E2 form ... See full document
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Functional Analysis of Cell Surface-Expressed Hepatitis C Virus E2 Glycoprotein
... and E2 localize to the ER in infected cells (4, 6, ...flaviviruses, virus morphogenesis may involve budding into the ER and subse- quent transport of viral particles through the host cell secretory pathway ... See full document
9
Conformational Flexibility in the Immunoglobulin Like Domain of the Hepatitis C Virus Glycoprotein E2
... The hepatitis C virus (HCV) glycoprotein E2 is the major target of neu- tralizing antibodies and is therefore highly relevant for vaccine ...the cellular receptor ... See full document
13
A Conserved Gly436-Trp-Leu-Ala-Gly-Leu-Phe-Tyr Motif in Hepatitis C Virus Glycoprotein E2 Is a Determinant of CD81 Binding and Viral Entry
... of E2, which resembles a class II fusion loop ...intra- cellular forms and mature virion-incorporated forms of the ...in CD81 receptor binding were detected in a recombinant LEL binding assay ... See full document
10
CD81 Is a Central Regulator of Cellular Events Required for Hepatitis C Virus Infection of Human Hepatocytes
... addition, CD81 has been shown to play a role in the infection of primary human hepatocytes by serum- derived HCV ...(45). CD81 is an integral membrane protein that shows the structure common to all ... See full document
14
Identification of Amino Acid Residues in CD81 Critical for Interaction with Hepatitis C Virus Envelope Glycoprotein E2
... Human CD81 has been previously identified as the putative receptor for the hepatitis C virus envelope glycoprotein ...human CD81 differs in four amino acid residues ... See full document
8
Structure-Function Analysis of Hepatitis C Virus Envelope-CD81 Binding
... surface CD81. It is known that virus attachment to a cell surface molecule per se does not necessarily lead to uptake and ...of cellular CD81 to internalize bound ligands by following ... See full document
7
Characterization of Hepatitis C Virus (HCV) and HCV E2 Interactions with CD81 and the Low-Density Lipoprotein Receptor
... an interaction between HCV or HCV-LDL complexes with the cellular low- density lipoprotein receptor ...promoted virus binding ...GB virus type C (also called hepatitis G ... See full document
8
Identification of a Residue in Hepatitis C Virus E2 Glycoprotein That Determines Scavenger Receptor BI and CD81 Receptor Dependency and Sensitivity to Neutralizing Antibodies
... mutant virus demonstrated a 10-fold increase in the sen- sitivity to neutralization by hCD81 LEL, suggesting an in- creased affinity of the gps for CD81 ...wt virus is con- sistent with an increased ... See full document
10
Expression and Characterization of a Minimal Hepatitis C Virus Glycoprotein E2 Core Domain That Retains CD81 Binding
... conserved E2 core do- main retained its ability to form complex structures, such as conformational monoclonal antibody (MAb) epitopes and the CD81 receptor-binding site, following deletion of the ... See full document
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