[PDF] Top 20 Characterization of Hepatitis B Virus (HBV)-Specific T-Cell Dysfunction in Chronic HBV Infection

... from chronic patients than in those from patients with acute hepatitis who resolved the ...general, HBV-specific T cells were rarely detected directly ex vivo in samples from ... See full document

... Human hepatitis B virus (HBV), which is the prototype member of the family Hepadnaviridae, is a circular, par- tially double stranded DNA virus of approximately 3200 nt ...[2]. ... See full document

... 3T3-msCD40L cell line, Cheng-I Wang (Singapore Immunology Network) for the anti–PD-1 Ab, Laura Rivi- no (Duke-NUS), and Yee Sin Leo ( Tan Tock Seng Hospital ) for pro- viding acute dengue patient samples, and also ... See full document

... Although chronic hepatitis B virus (HBV) infection is one of the most widespread chronic infectious diseases, its pathogen- esis and the mechanisms of viral persistence ... See full document

... of T-bet was in accordance with HBV specific CD8+ T cell ...cerning T-bet expression were observed in HIV infected patients ...that T-bet might regulate the level of the ... See full document

... and HBV DNA level, we found significantly lower adaptation in HBeAg- positive individuals for both genotypes B and ...comparing HBV sequences in individuals over a 20- to 35-year period, where ... See full document

... 1193-1198 0022-538X/92/021193-06$02.00/0 Copyright © 1992, American Society for Microbiology Hepatitis B Virus HBV-Specific Cytotoxic T-Cell CTL Response in Humans: Characterization of H[r] ... See full document

... of HBV or HBsAg during cyto- kine induced maturation of dendritic cells resulted in a more tolerogenic phenotype, as shown by a decreased T- cell stimulatory capacity ...for HBV are ... See full document

... titis B virus infection produce a strong, polyclonal, and multi- specific CTL response to HBV while patients with chronic hepatitis do not (3, 5, ...of HBV DNA and ... See full document

... of HBV virus (such as southern blot or protein analysis), we chose a PCR approach because it is the most sensi- tive method ...full-length HBV DNA by PCR, less sensitive methods are unlikely to ... See full document

... of HBV-specific T-cell responses present in patients with HBV infection, but these variables shape distinct HBV-specific T-cell ...“promiscuous” ... See full document

... that cell mediated immune responses are important in the elimination of viruses that do not have a lytic cycle in the host and for any tissue damage seen during either transient or persistent infection, or ... See full document

... 2679, Cell Signaling ...and specific signals were visualized with Alexa 488– or Alexa 555–labeled secondary antibodies (polyclonal, ...(Advanced Cell Diag- nostics), with target probes recognizing ... See full document

... expect HBV-specific T-cell responses also to decline following effective treatment; however, we found no change in the HBV-specific T-cell re- sponse despite ... See full document

... Functional hepatitis B virus (HBV)-specific T cells are significantly diminished in individuals chronically infected with HBV compared to individuals with self-limiting ... See full document

... total HBV DNA and covalently closed circular DNA (cccDNA) were measured by using the Invader assay, described previously, which has been fully validated and shown to be specific for cccDNA measurement ... See full document

... antigen-specific cell, has been associated with significantly better control of HIV-1 infection and slower disease progression (2, 4, ...from HBV-specific T cells, because we had ... See full document

... mRNA–electroporated T cells can recognize not only HBV peptide–pulsed target cells, but hepatocyte-like cells producing HBV virions from stable HBV-DNA integrations ...in HBV-infected ... See full document

... ant Hepatitis B surface protein and recombinant Hepatitis B core protein (ARP, American Research Products, ...HIV infection, were pulsed with 1 μg/mL gag peptide pool (comprised of 61 ... See full document

... cytotoxic T lymphocyte (CTL) response could be responsible for viral persistence during chronic hepatitis B virus ...the hepatitis B virus in several ... See full document