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Characterization of a human coronavirus (strain 229E) 3C-like proteinase activity.
... Human coronaviruses (HCV) are important medical patho- gens. They are known to cause respiratory infections in chil- dren and adults (26), and their involvement in human enteric disease seems likely (36). ... See full document
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The 3C-Like Proteinase of an Invertebrate Nidovirus Links Coronavirus and Potyvirus Homologs
... HCoV, human coronavirus (strain 229E) (X69721); TGEV, transmissible gastroenteritis virus (strain Purdue 115) (Z34093); PEDV, porcine epidemic diarrhea virus (strain CV777) (NC_003436); MHVA, murine ... See full document
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Genetic Screen for Monitoring Severe Acute Respiratory Syndrome Coronavirus 3C-Like Protease
... ment did not prevent the infection of laboratory researchers with this virus (17). It is important to emphasize that last winter the reported cases of SARS, after the outbreak was contained in July 2003, were due to ... See full document
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Processing of the Human Coronavirus 229E Replicase Polyproteins by the Virus-Encoded 3C-Like Proteinase: Identification of Proteolytic Products and Cleavage Sites Common to pp1a and pp1ab
... 1 Processing of the Human Coronavirus 229E Replicase Polyproteins by the Virus-Encoded 3C-Like Proteinase: Identification of Proteolytic Products and Cleavage Sites Common to pp1a and pp[r] ... See full document
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Characterization of a second cleavage site and demonstration of activity in trans by the papain-like proteinase of the murine coronavirus mouse hepatitis virus strain A59.
... The activity of the second-site triple mutant D Msc CAG3RGV (54%) appears to have been negatively determined by the substitution of the glycine with a valine at the P1 9 position, as suggested by the low level of ... See full document
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Assessing Activity and Inhibition of Middle East Respiratory Syndrome Coronavirus Papain-Like and 3C-Like Proteases Using Luciferase-Based Biosensors
... novel coronavirus Middle East respiratory syndrome coro- navirus (MERS-CoV; previously known as London1, novel CoV, and human CoV-EMC) was first identified in 2012 in pa- tients suffering from severe ... See full document
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Biologic, Antigenic, and Full-Length Genomic Characterization of a Bovine-Like Coronavirus Isolated from a Giraffe
... antigenic characterization of a bovine-like CoV from a giraffe (Giraffa camelopardalis) in a wild-animal park in the United ...in human rectal tumor 18 cell ...enzyme activity, ... See full document
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The Papain-Like Protease of Severe Acute Respiratory Syndrome Coronavirus Has Deubiquitinating Activity
... syndrome coronavirus (SARS-CoV) is mediated by replicase polyproteins that are processed by two viral proteases, papain-like protease (PLpro) and 3C-like protease ...and ... See full document
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Identification of a Novel Cleavage Activity of the First Papain-Like Proteinase Domain Encoded by Open Reading Frame 1a of the Coronavirus Avian Infectious Bronchitis Virus and Characterization of the Cleavage Products
... Expression of the IBV sequence from nucleotides 2545 to 9786. In a previous report, we demonstrated that the first cleavage product of the 1a and 1a/1b polyproteins is an 87-kDa protein encoded by ORF 1a between ... See full document
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Proteolytic Processing and Deubiquitinating Activity of Papain-Like Proteases of Human Coronavirus NL63
... Human coronavirus NL63 (HCoV-NL63), a common human respiratory pathogen, is associated with both upper and lower respiratory tract disease in children and ...that, like severe acute ... See full document
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Cinanserin Is an Inhibitor of the 3C-Like Proteinase of Severe Acute Respiratory Syndrome Coronavirus and Strongly Reduces Virus Replication In Vitro
... (41) activity were demonstrated in laboratory ani- ...anti-SARS-CoV activity of the drug demonstrated here, it might be worthwhile to reevaluate the existing pharmacologi- cal data and to test the drug with ... See full document
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Proteolytic Processing at the Amino Terminus of Human Coronavirus 229E Gene 1-Encoded Polyproteins: Identification of a Papain-Like Proteinase and Its Substrate
... the coronavirus gene 1-encoded polyproteins, pp1a and pp1ab, is linked to a series of pro- teolytic events involving virus-encoded ...the human coronavirus 229E-encoded papain-like cysteine ... See full document
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Identification of Severe Acute Respiratory Syndrome Coronavirus Replicase Products and Characterization of Papain-Like Protease Activity
... the coronavirus associated with severe acute respiratory syndrome (SARS) encodes replicase poly- proteins that are predicted to be processed into 16 nonstructural proteins (nsps 1 to 16) by two viral proteases, a ... See full document
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Identification of Mouse Hepatitis Virus Papain-Like Proteinase 2 Activity
... cysteine proteinase of EAV is responsible for generating the hydrophobic nsp3 replicase product, which is analogous to the MHV p44 ...avian coronavirus infectious bronchitis virus (IBV) also releases a ... See full document
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Structural and functional characterization of MERS coronavirus papain-like protease
... pathogenic human coronavirus (CoV), Middle East respiratory syndrome coronavirus (MERS-CoV), has emerged in Jeddah and Saudi Arabia and quickly spread to some European countries since September ... See full document
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Expression of Murine Coronavirus Recombinant Papain-Like Proteinase: Efficient Cleavage Is Dependent on the Lengths of both the Substrate and the Proteinase Polypeptides
... papain-like proteinase (PLP) domains, PLP-1 and ...cleavage activity when incubated with in vitro-synthesized viral polypeptide ...Subsequent characterization of the recombinant PLP-1 revealed ... See full document
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Identification and characterization of a serine-like proteinase of the murine coronavirus MHV-A59.
... of coronavirus 3C-like proteinases with chymotrypsin and serine-like proteinases of plus-strand RNA ...chymotrypsin, human rhinovirus 14 (HRV14), and hepatitis A virus (HAV) have been ... See full document
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Characterization in vitro of an autocatalytic processing activity associated with the predicted 3C-like proteinase domain of the coronavirus avian infectious bronchitis virus.
... cessing activity, and the data correlate with the minimal size estimated to be required for processing from the pulse-chase experiment described earlier ...processing activity, indi- cating that the major ... See full document
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Biosynthesis, purification, and characterization of the human coronavirus 229E 3C-like proteinase.
... enzymatic activity of the coronavirus ...full activity. We believe that the carboxyl-terminal region of coronavirus 3C-like pro- teinases, which has no counterpart in other ... See full document
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Characterization of an Alphamesonivirus 3C-Like Protease Defines a Special Group of Nidovirus Main Proteases
... and coronavirus sequences used in this analysis include the following: equine arteritis virus (Bucyrus), NC_002532; simian hemor- rhagic fever virus, NC_003092; porcine reproductive and respiratory syn- drome ... See full document
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