[PDF] Top 20 Characterization of the Nuclear Localization Signal of the Borna Disease Virus Polymerase
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Characterization of the Nuclear Localization Signal of the Borna Disease Virus Polymerase
... L-NLS mutant localizes to the cytoplasm. Analysis of L truncation mutants fused with the flag epitope tag and -ga- lactosidase suggested that an L-NLS was located between aa 824 to 853. To test this hypothesis, BSR-T7 ... See full document
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Functional Characterization of the Nuclear Localization Signal for a Suppressor of Posttranscriptional Gene Silencing
... these mutant viruses retained the ability to replicate in proto- plasts (18). TYLCV-C infection, and indeed transient expres- sion of the C2 protein via agroinfiltration, effectively overcame the local and systemic ... See full document
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Characterization of the Human Herpesvirus 6 U69 Gene Product and Identification of Its Nuclear Localization Signal
... nucleopolyhedrosis virus DNA (BaculoGold; BD PharMingen), and the recombinant baculoviruses were ex- panded into high-titer virus stocks by following the manufacturer’s ... See full document
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Fabrication and characterization of nuclear localization signal-conjugated glycol chitosan micelles for improving the nuclear delivery of doxorubicin
... here, nuclear localization signal (NLS)- modified polymeric micelles were studied with the aim of improving nuclear drug ...proton nuclear magnetic resonance spectroscopy, dynamic light ... See full document
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Multifunctionality of a Picornavirus Polymerase Domain: Nuclear Localization Signal and Nucleotide Recognition
... foot-and-mouth disease virus (FMDV) 3D polymerase contains the sequence MRKTKLAPT (resi- dues 16 to 24) that acts as a nuclear localization ...structural characterization of ... See full document
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Characterization of the P Protein-Binding Domain on the 10-Kilodalton Protein of Borna Disease Virus
... The Borna disease virus (BDV) belongs to a new family of enveloped, negative, nonsegmented, single-stranded RNA vi- ...The virus causes central nervous system disease in di- verse ... See full document
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Dual function of the nuclear export signal of the Borna disease virus nucleoprotein in nuclear export activity and binding to viral phosphoprotein
... viral polymerase activity, we used a modi- fied minigenome assay as previously reported ...viral polymerase activity was completely lost ...viral polymerase activity compared to wild-type BoDV-N ... See full document
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A Methionine-Rich Domain Mediates CRM1-Dependent Nuclear Export Activity of Borna Disease Virus Phosphoprotein
... Borna disease virus (BDV) is a nonsegmented, negative-strand RNA virus that replicates and transcribes in the nucleus of infected ...subcellular localization through binding to the ... See full document
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Borna Disease Virus Nucleoprotein Requires both Nuclear Localization and Export Activities for Viral Nucleocytoplasmic Shuttling
... Therefore, nuclear im- port and export of the viral genome are critical to the life cycle of viruses in mammalian ...these virus employ mechanisms by which the viral nucleic acids enter and leave the ... See full document
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The role of nuclear localization signal in parvovirus life cycle
... the nuclear pore complex freely or by passive diffusion, while the larger proteins (>50 kDa) require active trans- ...herpes- virus VP1/2 capsid protein is important for infection via capsid routing to ... See full document
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Two Proline-Rich Nuclear Localization Signals in the Amino- and Carboxyl-Terminal Regions of the Borna Disease Virus Phosphoprotein
... L polymerase is thought to be a constituent of a viral ribonucleoprotein complex required for the replication and transcription of BDV genome in the nucleus (3, ...L polymerase has basic amino acid clus- ... See full document
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Borna Disease Virus Matrix Protein Is an Integral Component of the Viral Ribonucleoprotein Complex That Does Not Interfere with Polymerase Activity
... such signal was observed in uninfected ...subcellular localization of M in BDV-infected ...punctate nuclear local- ization of M ...These nuclear “dots” are typical for BDV infection and have ... See full document
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Characterization of Borna disease virus p56 protein, a surface glycoprotein involved in virus entry.
... our virus preparations by membrane-bound proteins that would not actually be present in the ...the localization of such processes, remain to be ...the nuclear envelope and ...intracellular ... See full document
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Dissection of a Novel Nuclear Localization Signal in Open Reading Frame 29 of Varicella-Zoster Virus
... subcellular localization of the GFP fusion pro- teins was determined by direct fluorescence ...subcellular localization of the truncated ORF29 proteins that accumulate in transfected 293T ...the ... See full document
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Two signals mediate nuclear localization of influenza virus (A/WSN/33) polymerase basic protein 2.
... In one region, four basic residues K-736 R K R played a critical role in the nuclear translocation of PB2, since the deletion or mutation of these residues rendered the protein totally c[r] ... See full document
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Characterization of the Nuclear Export Signal in the Coronavirus Infectious Bronchitis Virus Nucleocapsid Protein
... subcellular localization in both virus-infected cells and cells expressing the N protein (21, 31, 38, 40, ...drome virus N protein NLS revealed that nuclear localization of the protein ... See full document
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Borna Disease Virus Infection Impairs Synaptic Plasticity
... extracellular signal-regulated kinase (ERK)1/2 has been shown to be essential for the development of a long- lasting increase in neuronal network activity, in particular fol- lowing exposure to bicuculline ... See full document
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Sequence similarity between Borna disease virus p40 and a duplicated domain within the paramyxovirus and rhabdovirus polymerase proteins.
... The sequence analysis suggests that p40 last shared a common ancestor with the rhabdovirus and paramyxovirus sequences prior to the duplication event that gave rise to the extant polymer[r] ... See full document
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Polymerase Read-Through at the First Transcription Termination Site Contributes to Regulation of Borna Disease Virus Gene Expression
... compare virus spread in brain tissue, we infected 26-day-old rats with 2,000 focus-forming units of either wild-type or mutant ...of virus infection, brain sections were stained with a monoclonal antibody ... See full document
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Persistence of Borna Disease Virus in Naturally Infected Sheep
... sure on the N-terminal part of the glycoprotein, since the C-terminal part is much more conserved. Viruses from the horses did not show a higher degree of similarity to each other (40) than to the sheep-derived ... See full document
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