[PDF] Top 20 Claudin-12 is not required for blood–brain barrier tight junction function
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Claudin-12 is not required for blood–brain barrier tight junction function
... with barrier properties of the BBB ...the claudin family, which exert different functions and present tissue and devel- opmental stage specific expression patterns ...as claudin-1 and ... See full document
17
Cinnamicaldehyde regulates the expression of tight junction proteins and amino acid transporters in intestinal porcine epithelial cells
... for claudin-4, ZO-1, ZO-2, and ZO-3, which are corre- lated well with augmented TEER values in IPEC-1 cells ...The claudin family proteins and ZO family proteins, play a crucial role in establishing ... See full document
8
Mouse Adenovirus Type 1-Induced Breakdown of the Blood-Brain Barrier
... form tight junctions between adjacent cells (17, 34, 35, 46, ...and claudin-5 staining was localized to the periphery of mock- infected pmBECs, creating a cobblestone-like appearance ...Another tight ... See full document
13
The microbiota and gut-brain axis
... by tight junctions, which are complex protein structures made of transmembrane proteins, such as claudin, occludin, and tricellulin ...a barrier to paracellular diffusion of fluid and solutes. ... See full document
8
Exposure to vehicle emissions results in altered blood brain barrier permeability and expression of matrix metalloproteinases and tight junction proteins in mice
... of claudin and occludin were measured in cerebral microvessels (n = 4), and iNOS and IL-1β from the parenchyma (temporal lobe) (n = 5), from the brains of separate group of study animals via Western ...proteins ... See full document
14
Analysis of Xenopus laevis claudin (Xcla) Tight Junction Genes in Development
... Mouse claudin 5 is ubiquitously expressed in the endothelial cells of all tissues, except in kidney (only in arteries) (Morita et ...endothelial-cadherin, claudin 5 is an endothelial specific claudin ... See full document
73
Tight junctions of the outer blood retina barrier
... The ZO proteins belong to the family of membrane associated guanylate kinases (MAGUK) that possesses a distinct molecular organisation. The core structure is composed of one or more PDZ domains, a Src homology 3 (SH3) ... See full document
12
Expression and localization of claudins-3 and -12 in transformed human brain endothelium
... the claudin superfamily are important pro- tein constituents of tight junctions (TJs) in polarized epithelial and endothelial monolayers and play an important role in maintaining the paracellular ...the ... See full document
5
Kv1.3 channel blocker (ImKTx88) maintains blood–brain barrier in experimental autoimmune encephalomyelitis
... the junction complex, forming a seal in the endothelial cells to prevent solutes from undergoing paracellular dif- fusion and to mediate the gate function of the BBB ...and claudin-5) during ...and ... See full document
13
Enhancement of Blood-Brain Barrier Permeability and Reduction of Tight Junction Protein Expression Are Modulated by Chemokines/Cytokines Induced by Rabies Virus Infection
... and claudin-5 expres- sion in BMECs incubated with a supernatant containing ...by brain-resident cells such as neurons, microglial cells, and astrocytes (50, 51); it can also be produced by the infiltrating ... See full document
13
Silver nanoparticles induce tight junction disruption and astrocyte neurotoxicity in a rat blood–brain barrier primary triple coculture model
... A Ag-NPS (2,000 μ g/mL) was purchased from Nanux (SL1105001, Korea). PS-NP powder was purchased from Base Line Chrom Tech Research Centre (6-1-0005, People’s Republic of China). The PS-NP powder was dispersed in sterile ... See full document
15
Developmental Profile of Claudin-3, Claudin-5, and Claudin-16 Tight Junction Proteins in the Chick Intestine.
... of blood vessels in the mouse brain (Morita et ...capillary blood vessels, endothelial cells are attached to each other by TJs, and TJs form blood brain barrier (BBB) having very ... See full document
110
Original Article Panaxatriol saponins attenuate blood-brain barrier disruption in rats following transient middle cerebral artery occlusion
... of tight junctions has been pos- itively associated with MMP-9 activity and TJ proteins such as claudin-5 and occludin have been shown to bedegraded by MMP-9 through cleavage of portions of their ... See full document
12
Claudin 5: Gatekeeper of neurological function
... leaky barrier contributes to the generation of seizures, leading to more seizures which trigger further barrier dysfunction leading to epilepsy progression ...the tight junc- tion in epileptogenesis ... See full document
15
Necrotizing enterocolitis leads to disruption of tight junctions and increase in gut permeability in a mouse model
... ability barrier, such as the blood brain barrier in claudin-5-deficient mice [37], the blood brain barrier in adult zebrafish [38], and the pathogen-infected ... See full document
8
Blood–brain barrier and intestinal epithelial barrier alterations in autism spectrum disorders
... At the protein level, CLDN-5 is elevated in the ASD cortex, consistent with its mRNA expression, whereas, on the other hand, CLDN-12 is significantly reduced. An increased gene expression of sealing TJ components ... See full document
17
"Targeted disruption of the epithelial-barrier by Helicobacter pylori"
... gastric function, and the highly orga- nized nature of gastric glands is essential for regulating gastric integrity and maintaining a protective barrier between harmful luminal contents and the underlying ... See full document
11
Intestinal nutrient transport in the cradle of the Mediterranean Diet: 23rd EITG meeting report
... “Intestinal barrier physiology”, was introduced by a keynote lecture by Michael Müller (Wageningen University, The Netherlands), who presented results from his laboratory on the role of dietary lipids in the ... See full document
7
Acute Modulations in Stratum Corneum Permeability Barrier Function Affect Claudin Expression and Epidermal Tight Junction Function via Changes of Epidermal Calcium Gradient
... permeability barrier disruption on the expression and localization of TJ proteins, Cldn-1 and Cldn-4 in murine ...TJ, tight junction; Cldn, ... See full document
6
Development of Claudin 2 and Claudin 4 in Embryonic and Hatched Chick Intestine
... The claudin 16 gene was identified by screening kindreds with a recessive form of renal hypomagnesia, later termed Familial hypomagnesemia with hypercalciuria and nephrocalcinosis (FHHNC) (OMIM accession number ... See full document
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