[PDF] Top 20 Clonidine for sedation in the critically ill: a systematic review and meta-analysis (protocol)

... The Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach will be used to assess the quality of evidence for each outcome [27]. The GRADE system classifies the qual- ity of the aggregate body ... See full document

... We found no significant difference in the duration of IMV, ICU mortality, duration of sedation infusion or ICU length of stay between the clonidine and non-clonidine groups. However, a high degree of ... See full document

... This systematic review will also include a hand- search of the past 10 years of published abstracts from the conference proceedings of the World Federation of Neurological Surgeons and the European ... See full document

... Peer Review of Electronic Search Strategies checklist ...of Systematic Reviews, the Cochrane Central Register of Controlled Trials (CENTRAL) for three domains: cytomegalovirus, intensive care unit, and ... See full document

... less sedation is not associated with impaired long-term cognitive ...to sedation per usual care ...recent meta- analysis nor the BRAIN-ICU study found that low sedation levels were ... See full document

... A study screening form will be developed based on the inclusion and exclusion criteria for study screening and selection. Using Covidence software, two independent authors (SRD, AL) will determine eligibility of studies ... See full document

... Methods: We will search the following from 1980 to March 2016: Ovid MEDLINE, CINAHL, Embase, PsycINFO, and Web of Science. We will also search the Cochrane Library, gray literature, and the International Clinical Trials ... See full document

... this protocol-driven systematic review and meta-analysis follows the Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) and ... See full document

... These conflicting results may be related to differences in study populations, selection bias and immortal time bias (nutritional intake is better for patients who survive and have a longer ICU stay). Prescribed ... See full document

... Statistical analysis was performed using the comprehen- sive meta-analysis program. Statistics were pooled using random effect model; odds ratios (OR) for binary outcomes, with 95% confidence ... See full document

... of critically ill chil- dren showing that TGC of 80–110 mg/dl reduced hos- pital mortality by half, and reduced the infection rate and length of stay, but also presented extremely high rates of severe ... See full document

... However, our study has limitations. We included only studies in English. We were also unable to exclude publi- cation bias, and negative studies may be missing, poten- tially resulting in overestimation of the effect ... See full document

... subgroup analysis to attempt to elucidate potentially more beneficial treatment strate- ...seriously ill patients, we compared studies of patients with higher mortality in the control group ...subgroup ... See full document

... Given that the SSC guideline emphasizes early diagnosis to improve the clinical outcomes in sepsis [3], develop- ing diagnostic strategies for infection is still required for accurate bedside diagnosis of infections. ... See full document

... In 2013, after aggregating six RCTs evaluating the ef- fect of parenteral FO-containing LEs on relevant clinical outcomes in a heterogeneous ICU patient population [10], we demonstrated that FO-containing LEs may be able ... See full document

... differences in volume of distribution between the two ions [4]. This effect may not be seen with more balanced fluids such as Hartman’s solution but, given that normal saline is commonly used in clinical practice, a risk ... See full document

... reports, review, the letters, and comments were excluded from the primary ...‘‘critically ill’’, post-operative (including post-operative, post-operation, and sur- ...for sedation less than 6h ... See full document

... This review also sought to investigate the relationship of VDD with illness severity, ICU interventions, and clinical ...to meta-analysis that is accepted as meaningful [81, ...from systematic ... See full document

... subgroup analysis to assess a number of possible influences on the effect of enteral GLN supplementation on clinical ...subgroup analysis of patients with trauma, and we were able to obtain the data for the ... See full document

... in critically ill pa- tients are retrospective observational investigations, with only one prospective before-after study supporting the safety of a more conservative ... See full document