[PDF] Top 20 Complementation of Vaccinia Virus Lacking the Double-Stranded RNA-Binding Protein Gene E3L by Human Cytomegalovirus
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Complementation of Vaccinia Virus Lacking the Double-Stranded RNA-Binding Protein Gene E3L by Human Cytomegalovirus
... of protein synthesis. Since viruses require continued protein synthesis for replication, many have evolved strategies to coun- teract the PKR and 2-5A synthetase pathways ...viral protein synthesis ... See full document
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Vaccinia Virus Subverts a Mitochondrial Antiviral Signaling Protein-Dependent Innate Immune Response in Keratinocytes through Its Double-Stranded RNA Binding Protein, E3
... cinia virus dsRNA-binding protein E3, which can inhibit the PKR and NF- B pathways (10, 14, 38) that would otherwise be activated by vaccinia virus ...mutant vaccinia ... See full document
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Possible Involvement of the Double-Stranded RNA-Binding Core Protein ςA in the Resistance of Avian Reovirus to Interferon
... most virus-cell systems, the molecular mechanisms responsible for this inhibition remain largely un- ...viral protein synthesis observed in rcIFN-treated cells in- fected with VSV and vaccinia ... See full document
8
Dissection of Double-Stranded RNA Binding Protein B2 from Betanodavirus
... dsRNA binding and ...B2 protein of a betanodavirus from orange- spotted grouper (32), confirming the importance of these res- ...dsRNA binding can only be predicted, but it is of obvious significance ... See full document
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Human Cytomegalovirus TRS1 and IRS1 Gene Products Block the Double-Stranded-RNA-Activated Host Protein Shutoff Response Induced by Herpes Simplex Virus Type 1 Infection
... a protein that enabled eva- sion of the interferon-mediated antiviral ...a vaccinia recombinant published studies showing that HCMV encodes a gene product that permits continued protein ... See full document
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Double-stranded RNA-activated protein kinase PKR of fishes and amphibians: Varying the number of double-stranded RNA binding domains and lineage-specific duplications
... the Vaccinia virus proteins E3L and K3L, orthologs of which are found in many ...poxviruses. E3L and K3L are important virulence factors and are involved in determining host range ...[53]. ... See full document
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Double-Stranded RNA Binding by a Heterodimeric Complex of Murine Cytomegalovirus m142 and m143 Proteins
... by double-stranded (ds) RNA. Among these are the protein kinase R and oligoadenylate synthetase/ RNase L pathways, both of which result in the shutoff of protein ...including ... See full document
8
Reversal of the interferon-sensitive phenotype of a vaccinia virus lacking E3L by expression of the reovirus S4 gene.
... The vaccinia virus (VV) E3L gene, which encodes a potent inhibitor of the interferon (IFN)-induced, double-stranded RNA (dsRNA)-dependent protein kinase, PKR, is ... See full document
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Blockade of Interferon Induction and Action by the E3L Double-Stranded RNA Binding Proteins of Vaccinia Virus
... The vaccinia virus E3L gene encodes two double-stranded RNA binding proteins that promote viral growth and pathogenesis through suppression of innate ...how ... See full document
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Double-Stranded RNA Binding by Human Cytomegalovirus pTRS1
... The human cytomegalovirus (HCMV) TRS1 and IRS1 genes rescue replication of vaccinia virus (VV) that has a deletion of the double-stranded RNA binding protein ... See full document
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RNA recognition by double-stranded RNA binding domains: a matter of shape and sequence
... an RNA stem–loop deriving from a natural substrate of ADAR2, show that the side chain of the methionine extends into the RNA minor groove where the methyl group makes a hydrophobic contact with the edge of ... See full document
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Arabidopsis Double-Stranded RNA Binding Protein DRB3 Participates in Methylation-Mediated Defense against Geminiviruses
... five double-stranded RNA binding (DRB) ...interfering RNA (siRNA) pathways. DRB3 and DRB5 are not involved in double-stranded RNA (dsRNA) processing but assist in ... See full document
12
Molecular Genetic and Biochemical Characterization of the Vaccinia Virus I3 Protein, the Replicative Single-Stranded DNA Binding Protein
... I3 protein has been shown to stimulate polymerase-mediated strand-joining in vitro (59), and partial depletion of I3 (3- to ...fectious virus production ...a virus in which the I3 locus has been ... See full document
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Inhibition of binding to initiation complexes of nascent reovirus mRNA by double-stranded RNA-dependent protein kinase.
... Of necessity, experiments designed to examine whether the binding of nascent reovirus mRNA to initiation complexes was preferentially inhibited in the coupled, cell-free system had to be[r] ... See full document
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RNA-Binding Activity of the Rotavirus Phosphoprotein NSP5 Includes Affinity for Double-Stranded RNA
... dsRNA- binding activity of NSP5 in vivo is probably not genomic dsRNA, as access to this RNA by a nonstructural protein would be prevented by the shell of the ...a protein with ... See full document
9
Characterization of a Novel Megabirnavirus from Sclerotinia sclerotiorum Reveals Horizontal Gene Transfer from Single-Stranded RNA Virus to Double-Stranded RNA Virus
... novel double-stranded RNA (dsRNA) mycovirus, Sclerotinia sclerotiorum megabirnavirus 1 (SsMBV1), in an apparently hypovirulent strain (SX466) of Sclerotinia ...coat protein and an ... See full document
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Localization of the Single-Stranded RNA-Binding Domains of Bluetongue Virus Nonstructural Protein NS2
... S2 gene of bluetongue virus, serotype 17, has been cloned, and the nonstructural protein NS2 has been ...single-stranded RNA (ssRNA)-binding regions within the ...truncated ... See full document
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Overlapping genes in a yeast double-stranded RNA virus.
... One of the products of in vitro translation of the denatured viral double-stranded RNA is a polypeptide of the size expected of a capsid-polymerase fusion protein, resulting from a -1 fr[r] ... See full document
8
Sequestration and Protection of Double-Stranded RNA by the Betanodavirus B2 Protein
... nonstructural virus-encoded dsRNA binding proteins have been characterized in recent years (4, 11, 13, 33) and most of these proteins have been implicated in the suppression of one or more of the host ... See full document
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Double-Stranded RNA-Mediated Interference with Plant Virus Infection
... extreme virus resistance when sense and antisense virus-derived transgenes are simul- taneously expressed in a ...the virus could interfere with infection in a se- quence-specific ...Sense RNA ... See full document
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