[PDF] Top 20 Comprehensive Analysis of Ebola Virus GP1 in Viral Entry
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Comprehensive Analysis of Ebola Virus GP1 in Viral Entry
... the Ebola virus GP1 glycoprotein are important for understanding the entry mechanism of filoviruses and for development of therapeutic ...in GP1 folding or structure stability ...the ... See full document
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Comprehensive Functional Analysis of N Linked Glycans on Ebola Virus GP1
... ABSTRACT Ebola virus (EBOV) entry requires the virion surface-associated glycoprotein (GP) that is composed of a trimer of heterodimers ...The GP1 subunit contains two heavily glycosylated ... See full document
9
Characterization of Ebola Virus Entry by Using Pseudotyped Viruses: Identification of Receptor-Deficient Cell Lines
... rabies virus and hepatitis B virus from infected individuals (11, 17), and it has been suggested that the administration of neutralizing antibod- ies early in the course of an Ebola virus ... See full document
6
Role of Endosomal Cathepsins in Entry Mediated by the Ebola Virus Glycoprotein
... of viral entry, VSV-GP was either mock treated (no enzyme) or treated with CatB plus CatL or thermolysin for 20 min (con- ditions generally yielding maximal, although not complete, conversion to the 19-kDa ... See full document
5
Suramin is a potent inhibitor of Chikungunya and Ebola virus cell entry
... of viral infections are carried out by the viral glycoproteins which mediate attachment and entry of the virus into the target ...heterologous viral glycoprotein (GP) and thereby ... See full document
8
The Tetherin Antagonism of the Ebola Virus Glycoprotein Requires an Intact Receptor-Binding Domain and Can Be Blocked by GP1-Specific Antibodies
... cell entry, as expected from a previous analysis (60), but may be incompatible with efficient tetherin ...present analysis (not ...in viral entry (50, 61, ...abrogate viral ... See full document
12
A Polymorphism within the Internal Fusion Loop of the Ebola Virus Glycoprotein Modulates Host Cell Entry
... immunoblot analysis: the wild-type, mutant, and chimeric GP were detected using a GP1-specific rabbit serum (1:5,000) and a peroxidase-coupled anti-rabbit secondary antibody (Dianova; ... See full document
14
Biochemical Analysis of the Secreted and Virion Glycoproteins of Ebola Virus
... the GP1 and GP2 molecules is yet to be identified (as are those holding the SGP dimer ...to GP1, then only one cysteine in GP2 should be available for bonding with one of the five cysteines in GP1 ... See full document
6
Growth-Adaptive Mutations in the Ebola Virus Makona Glycoprotein Alter Different Steps in the Virus Entry Pathway
... for virus attachment and entry into ...alter virus growth ...change virus growth ...tis virus (VSV), two of which also occur during passage of EBOV clinical isolates in tissue ... See full document
16
Spontaneous Mutation at Amino Acid 544 of the Ebola Virus Glycoprotein Potentiates Virus Entry and Selection in Tissue Culture
... in virus growth kinetics and conferred a robust growth advantage over wild-type rVSV-MAK-GP on Vero E6 ...cells. Analysis of complete viral genomes collected from patients in western Africa indi- ... See full document
16
Rho GTPases Modulate Entry of Ebola Virus and Vesicular Stomatitis Virus Pseudotyped Vectors
... of entry for Ebola virus (EBOV) glycoprotein (GP) pseudotyped virions, we used comparative gene analysis to identify genes whose expression correlated with viral ...stomatitis ... See full document
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A Hyperstabilizing Mutation in the Base of the Ebola Virus Glycoprotein Acts at Multiple Steps To Abrogate Viral Entry
... A virus hemagglutinin (HA), showing that single mutations can have profound impacts on the stability of HA, as measured by changes in the pH threshold of fusion (25, ...of GP1 with no known function and no ... See full document
15
Biochemical and Structural Characterization of Cathepsin L-Processed Ebola Virus Glycoprotein: Implications for Viral Entry and Immunogenicity
... the GP1 region (orange; residues 31 to 500), with the RBD (dark-dotted orange; residues 54 to 201) and the MUC domain (white-dotted orange; residues 309 to 500), the GP2 region (green; residues 501 to 647), signal ... See full document
11
Mathematical Analysis of Aerodynamic Potential of Ebola Virus Particle
... the Ebola virus. This micrograph illustrates the fact that the Ebola virus has a rod-shaped morphology which can twist and overlap ...this virus. As one can clearly see from the ... See full document
6
Viral Replication and Host Gene Expression in Alveolar Macrophages Infected with Ebola Virus (Zaire Strain)
... other viral proteins (NS1 of influenza virus A), VP35 may inhibit the dsRNA-induced activation of transcription factors needed for IFN-␣/ gene ...influenza virus A blocks IFN- production by ... See full document
9
Hepatitis C Virus entry: the early steps in the viral replication cycle
... CD81 was recognized early as an entry receptor for HCV [43]. CD81 is a member of the tetraspanin family of pro- teins. Tetraspanins are type III membrane glycoproteins which span the membrane 4 times and therefore ... See full document
11
Novel Stable Ebola Virus Minigenome Replicon Reveals Remarkable Stability of the Viral Genome
... The viral RNA genome, approximately 19 kb in length, encodes 8 major viral proteins: nucleoprotein (NP), viral protein 35 (VP35), VP40, VP30, VP24, glycoprotein (GP), soluble glycoprotein (sGP), and ... See full document
14
Curability of Ebola Virus – A Scientometric Approach to Ebola Virus Research
... In any subject, the scholars who are publishing their scientific communication continuously are called as continuant authors and those who publish sporadically are termed as transient authors. The more the continuant ... See full document
12
Ebola Virus VP40 Late Domains Are Not Essential for Viral Replication in Cell Culture
... on Ebola virus-like particles ...While Ebola VP40 is ubiquitinated by Nedd4-like ubiquitin ligases (13), it is currently not known if this event subsequently increases the affinity of VP40 for ... See full document
8
Protection from Ebola Virus Mediated by Cytotoxic T Lymphocytes Specific for the Viral Nucleoprotein
... lethal Ebola virus ...from Ebola virus and stresses the need to closely examine the ability of all viral proteins to induce pro- tective cellular immune responses for the development of ... See full document
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