[PDF] Top 20 Computational pathology of pre treatment biopsies identifies lymphocyte density as a predictor of response to neoadjuvant chemotherapy in breast cancer

... median lymphocyte density for each ...median lymphocyte density, pCR and molecular subtype is also depicted in ...median lymphocyte density and pCR significantly differed by ER ... See full document

... Our analyses were limited to tissue morphology in H&E slides. While this is a pragmatic and therefore clinically feasible approach, it overlooks functional differences in infiltrating lymphocytes, which have been shown ... See full document

... Cancer Treat Rev 2018; 62: 9-17. [16] Curigliano G, Burstein HJ, Winer EP, Gnant M, Dubsky P, Loibl S, Colleoni M, Regan MM, Pic- cart-Gebhart M, Senn HJ, Thürlimann B, André F, Baselga J, Bergh J, Bonnefoi H, ... See full document

... the chemotherapy response ...predict treatment sensitivity in HER2-positive breast cancer, when chemotherapy was combined with targeted anti-HER2 ...of cancer cell ... See full document

... the chemotherapy regimen used was internally con- sistent, we included all HER2-negative patients, resulting in a far more diverse patient population and thus increased heterogeneity in terms of response to ... See full document

... first-line treatment and switching NAC increased the chances of tumour ...tumour response by using an alternative NAC ...strongest predictor of pCR ... See full document

... of breast cancer with response and survival outcomes in a large combined dataset of newly diagnosed patients treated with multi-agent neoadjuvant chemotherapy and we made the following ... See full document

... V seg was a less sensitive pCR predictor than V calc . After the onset of therapy, contrast enhancement in tumour tissue is altered and the enhancement may resemble that of benign breast tissue. Thus, ... See full document

... therapy response, the univariate logistic regression (ULR) analysis was used to correlate V1, V2, V3 MRI metrics, and the corresponding V21% and V31% changes, with dichotomous pathologic response endpoints, ... See full document

... HER2- breast cancer, recent studies have indicated that chemotherapy indications follow an inverse pattern in relation to endocrine responsiveness ...for chemotherapy [20]. Our previous study ... See full document

... monitoring treatment response of locally advanced breast cancer patients undergoing neoadjuvant ...receiving neoadjuvant chemotherapy had the affected breast ... See full document

... calculated from absolute counts of serum lymphocytes and neutrophils, is performed routinely during preop- erative blood profile work, and is readily available. The findings suggest that SIR offers a novel therapeutic ... See full document

... demonstrated pre- clinically ...good response to combination ...with treatment-induced increases in perfusion and oxygenation (11, ...paired biopsies separated by 2 wk did not allow ... See full document

... of chemotherapy response and ...and pre-treatment accuracy and ...not pre-treatment, levels of AAGAB were significantly associated with the outcome in both ... See full document

... MRI modality is one of the most usual techniques used for diagnosis and treatment planning of breast cancer. The aim of this study is to prove that texture based feature techniques such as ... See full document

... tumor bed should be sampled has not been established. For initial sampling, 1 block per centimeter of pretreat- ment tumor size is reasonable. If residual tumor is found, additional sampling is not necessary. If no tumor ... See full document

... for breast cancer patients receiving previous NAC with different levels of plasma miR-221, their overall response rates ...prevalent pre- dictors for inferior DFS and rapid recurrence in ... See full document

... advanced breast cancer (LABC) represents a worldwide major challenge, with a reported incidence reaching up to ...for neoadjuvant chemotherapy (NACT) as primary approach to provide effective ... See full document

... the response to ...of neoadjuvant/adjuvant chemotherapy for breast cancer, considering different breast cancer ...(HER2)-negative breast cancers, various genomic ... See full document

... Although strain ultrasound would be a practical and resource- efficient imaging modality to monitor response to NAC, there are various limitations to its implementation in clinical practice. Strain ultrasound ... See full document