[PDF] Top 20 Conformational Flexibility in the Immunoglobulin Like Domain of the Hepatitis C Virus Glycoprotein E2
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Conformational Flexibility in the Immunoglobulin Like Domain of the Hepatitis C Virus Glycoprotein E2
... HCV glycoprotein E2, the CD81 binding loop, adopts more than one distinct confor- FIG 5 More than one conformation of the Ig-like domain was observed on both HCVpp and HCVcc infectious ... See full document
13
Structural Flexibility of a Conserved Antigenic Region in Hepatitis C Virus Glycoprotein E2 Recognized by Broadly Neutralizing Antibodies
... with hepatitis C virus (HCV), and neutralizing antibodies play an im- portant role in controlling the replication of this major human ...major glycoprotein E2 (amino acids 412 to 423), ... See full document
12
Identification of Conserved Residues in Hepatitis C Virus Envelope Glycoprotein E2 That Modulate Virus Dependence on CD81 and SRB1 Entry Factors
... of E2 protein ...on virus assembly also suggests that these res- idues are not involved in interactions with HCV glycoprotein E1, and the lack of effect on virus entry and interaction with ... See full document
14
Hepatitis C Virus Envelope Glycoprotein E2 Glycans Modulate Entry, CD81 Binding, and Neutralization
... by C-type lectins, neutralization, and recep- tor ...The E2 envelope glycoprotein comprises 11 N-linked glycans and four O-linked glycans (25, ...of E2 to mediate HCVpp entry into hepatoma ... See full document
8
Definition of a Conserved Immunodominant Domain on Hepatitis C Virus E2 Glycoprotein by Neutralizing Human Monoclonal Antibodies
... to E2 and high neutralizing activity ( ⬎ 1: 10,000 titer) against genotype 1a ...Epstein-Barr virus and used to produce human hybridomas, as described previously ...recombinant E2 proteins expressed ... See full document
6
Expression and Characterization of a Minimal Hepatitis C Virus Glycoprotein E2 Core Domain That Retains CD81 Binding
... conserved E2 core do- main retained its ability to form complex structures, such as conformational monoclonal antibody (MAb) epitopes and the CD81 receptor-binding site, following deletion of the three ... See full document
7
Identification of a Domain Containing B-Cell Epitopes in Hepatitis C Virus E2 Glycoprotein by Using Mouse Monoclonal Antibodies
... the conformational changes in the antigen due to the previous binding of the MAb(s) and the electrostatic interactions between the MAbs may distort the binding patterns of CET MAbs, the diagram does not corre- ... See full document
8
Identification of New Functional Regions in Hepatitis C Virus Envelope Glycoprotein E2
... and E2 as observed in the CD81 pull-down ...chimeric E2 proteins (data not ...and E2 envelope glycoproteins form large covalent complexes stabilized by disulfide bridges, whereas the intracellular ... See full document
16
Functional Analysis of Cell Surface-Expressed Hepatitis C Virus E2 Glycoprotein
... and E2 localize to the ER in infected cells (4, 6, ...flaviviruses, virus morphogenesis may involve budding into the ER and subse- quent transport of viral particles through the host cell secretory pathway ... See full document
9
Role of Conserved Cysteine Residues in Hepatitis C Virus Glycoprotein E2 Folding and Function
... (DMF10NEA). Immunoglobulin G14 (IgG14) was purified from plasma obtained from an HIV-infected indi- vidual using protein G Sepharose (GE Healthcare) according to the man- ufacturer’s ...within E2 and ... See full document
14
Mutagenesis of the fusion peptide-like domain of hepatitis C virus E1 glycoprotein: involvement in cell fusion and virus entry
... for virus propagation, various pseudotype viruses (HCVpp) expressing HCV E1 and E2 glycoproteins were developed in the past as mimics to study virus-cell inter- ...stomatitis virus (VSV) ... See full document
18
Analysis of a Highly Flexible Conformational Immunogenic Domain A in Hepatitis C Virus E2
... of domain A on HCV E2 glycoprotein? For TBEV, the major envelope glycoprotein E is organized in three antigenic domains that correspond to three structural domains, I, II, and ...III. ... See full document
10
Analysis of Antigenicity and Topology of E2 Glycoprotein Present on Recombinant Hepatitis C Virus-Like Particles
... Hepatitis C virus (HCV), the major cause of non-A, non-B hepatitis, is an enveloped virus classified in the Flaviviridae family (31, ...and E2 are located within the N terminus ... See full document
12
Immunogenic and Functional Organization of Hepatitis C Virus (HCV) Glycoprotein E2 on Infectious HCV Virions
... Hepatitis C virus (HCV) is a positive-stranded RNA virus containing at least three structural proteins—core and two envelope glycoproteins, E1 and E2—and six nonstructural proteins ... See full document
5
Identification of the Hepatitis C Virus E2 Glycoprotein Binding Site on the Large Extracellular Loop of CD81
... Hepatitis C virus (HCV) encodes a ⬃3,300-amino-acid poly- protein from which the E1 (polyprotein residues 191 to 383) and E2 (residues 384 to 746) glycoproteins are cleaved cotrans- ...and ... See full document
5
Identification of Conserved Residues in the E2 Envelope Glycoprotein of the Hepatitis C Virus That Are Critical for CD81 Binding
... Hepatitis C virus (HCV) cell entry involves interaction between the viral envelope glycoprotein E2 and the cell surface receptor ...conserved E2 determinants important for ... See full document
10
Characterization of Hepatitis C Virus E2 Glycoprotein Interaction with a Putative Cellular Receptor, CD81
... HCV E2 gp bound to the surface of the T-cell line Molt-4 and that this interaction could be inhibited both by a MAb specific for the hypervariable region (HVR) and by HCV-infected chimpanzee sera ...with ... See full document
10
Functional Characterization of Intracellular and Secreted Forms of a Truncated Hepatitis C Virus E2 Glycoprotein
... a TSK G4000PWXL (7.8 by 300 mm) column. The solvent used was PBS at a flow rate of 300 l/min. Column temperature was maintained at 30°C, and absorbance was monitored at 214 and 280 nm. Samples were injected in a ... See full document
8
Binding of Hepatitis C Virus E2 Glycoprotein to CD81 Does Not Correlate with Species Permissiveness to Infection
... Hepatitis C virus (HCV) glycoprotein E2 binds to human cells by interacting with the CD81 molecule, which has been proposed to be the viral ...for E2 has been ...with E2 ... See full document
6
Disulfide Bonds in Hepatitis C Virus Glycoprotein E1 Control the Assembly and Entry Functions of E2 Glycoprotein
... envelope glycoprotein E2 (12) and HIV envelope glycopro- tein ...influenza virus hemaggluti- nin, all disulfide bonds have been reported to be necessary for the protein to reach the native state ... See full document
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