[PDF] Top 20 A conserved neutralizing epitope on gp41 of human immunodeficiency virus type 1.
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A conserved neutralizing epitope on gp41 of human immunodeficiency virus type 1.
... These data suggest that the epitope of the MAb comprises the amino acid sequence ELDKWA corresponding to amino acids 662 to 667 of gpl60 of the HIV-1 BH1O isolate, with DKWA being the co[r] ... See full document
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Stable Docking of Neutralizing Human Immunodeficiency Virus Type 1 gp41 Membrane-Proximal External Region Monoclonal Antibodies 2F5 and 4E10 Is Dependent on the Membrane Immersion Depth of Their Epitope Regions
... of neutralizing antibodies 2F5 and 4E10 to human immunodeficiency virus type 1 (HIV-1) gp41 involves both the viral membrane and gp41 membrane proximal ... See full document
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Mutational Analysis of Conserved Domains within the Cytoplasmic Tail of gp41 from Human Immunodeficiency Virus Type 1: Effects on Glycoprotein Incorporation and Infectivity
... glycoprotein gp41 of human immunodeficiency virus type 1 possesses an unusu- ally long ( ⬃ 150 amino acids) and highly conserved cytoplasmic ...for virus ... See full document
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Role of a Putative gp41 Dimerization Domain in Human Immunodeficiency Virus Type 1 Membrane Fusion
... of human immunodeficiency virus type 1 (HIV-1) into a target cell entails a series of conforma- tional changes in the gp41 transmembrane glycoprotein that mediates the ... See full document
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Conserved, N-Linked Carbohydrates of Human Immunodeficiency Virus Type 1 gp41 Are Largely Dispensable for Viral Replication
... of human immunodeficiency virus type 1 (HIV-1) envelope protein con- tains four well-conserved sites for the attachment of N-linked ...simian immunodeficiency ... See full document
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An Affinity-Enhanced Neutralizing Antibody against the Membrane-Proximal External Region of Human Immunodeficiency Virus Type 1 gp41 Recognizes an Epitope between Those of 2F5 and 4E10
... of human immunodeficiency virus type 1 (HIV-1) gp41 bears the epitopes of two broadly neutralizing antibodies (Abs), 2F5 and 4E10, making it a target for vaccine ... See full document
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Evidence for a Stable Interaction of gp41 with Pr55Gag in Immature Human Immunodeficiency Virus Type 1 Particles
... of human immunodeficiency virus type 1 (HIV-1) culminates in the release of progeny virions from an infected cell via budding from the plasma ...(TM), gp41, which are ... See full document
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Inhibition of Human Immunodeficiency Virus Type 1 Infectivity by the gp41 Core: Role of a Conserved Hydrophobic Cavity in Membrane Fusion
... The gp41 envelope protein of human immunodeficiency virus type 1 (HIV-1) contains an ␣ -helical core structure responsible for mediating membrane fusion during viral ...a ... See full document
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A Conserved Tryptophan-Rich Motif in the Membrane-Proximal Region of the Human Immunodeficiency Virus Type 1 gp41 Ectodomain Is Important for Env-Mediated Fusion and Virus Infectivity
... the human immunodeficiency virus type 1 (HIV-1) transmembrane envelope glycoprotein, gp41, within a region immediately adjacent to the membrane-spanning ...highly ... See full document
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Dissection of Human Immunodeficiency Virus Type 1 Entry with Neutralizing Antibodies to gp41 Fusion Intermediates
... Human immunodeficiency virus type 1 (HIV-1) entry requires conformational changes in the transmem- brane subunit (gp41) of the envelope glycoprotein (Env) involving ... See full document
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Epitope map of human immunodeficiency virus type 1 gp41 derived from 47 monoclonal antibodies produced by immunization with oligomeric envelope protein.
... of gp41 that are impor- tant for binding of these MAbs, five linear MAbs (D3, D61, T30, D50, and T3) mapping to distinct regions in the ectodo- main of gp41 were used as landmarks ...for 1 h, the ... See full document
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Common immunologic determinant between human immunodeficiency virus type 1 gp41 and astrocytes.
... 1370 Downloaded from http://jvi.asm.org/ on November 10, 2019 by guest Monoclonal antibodies against a synthetic 12-amino-acid peptide that comprises the immunodominant domain of human i[r] ... See full document
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A Monoclonal Fab Derived from a Human Nonimmune Phage Library Reveals a New Epitope on gp41 and Neutralizes Diverse Human Immunodeficiency Virus Type 1 Strains
... acterized gp41 constructs, partially overlaps with that of mono- clonal antibody 5H/I1-BMV-D5 (D5) ...of gp41, thereby preventing formation of the fusogenic ...multiple gp41 molecules (16, ... See full document
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Determinants of Human Immunodeficiency Virus Type 1 Resistance to gp41-Derived Inhibitory Peptides
... intact gp41, the resistant mutants might be expected to either contain compensatory changes in the DP178 HR2 domain or exhibit functional abnormalities indicative of a poor association between these two ... See full document
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Independent fluctuation of human immunodeficiency virus type 1 rev and gp41 quasispecies in vivo.
... 4502 Downloaded from http://jvi.asm.org/ on November 10, 2019 by guest The human immunodeficiency virus type 1 HIV-1 overlapping rev and env coding sequences have been examined from sequ[r] ... See full document
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Fine Definition of the Epitope on the gp41 Glycoprotein of Human Immunodeficiency Virus Type 1 for the Neutralizing Monoclonal Antibody 2F5
... strong neutralizing activity against a broad range of HIV-1 primary isolates (8, 17, 39, 46, 47, ...Its epitope was previously determined by peptide re- activity as being a six-amino-acid sequence ... See full document
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Oligomeric structure of gp41, the transmembrane protein of human immunodeficiency virus type 1.
... Commercially prepared test strips containing solubilized HTLV-Illb lysates Organon Teknika were treated by standard protocols with the following antibodies: lane 1, human serum from a pa[r] ... See full document
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Novel Ring Structure in the gp41 Trimer of Human Immunodeficiency Virus Type 1 That Modulates Sensitivity and Resistance to Broadly Neutralizing Antibodies
... the gp41 trimer, Q at position 655 is located two turns from the terminus of the C34 helix ...a gp41 monomer pack together in a fairly standard antiparallel coiled- coil hairpin ...the gp41 trimer is ... See full document
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Mutation-Directed Chemical Cross-Linking of Human Immunodeficiency Virus Type 1 gp41 Oligomers
... the gp41 ectodo- main indicate that they pack into a trimer of peptide het- erodimers (9, ...a gp41 ectodomain fragment lacking the N-terminal fusion peptide, transmembrane domain, and cytoplasmic tail ex- ... See full document
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Determinants of Human Immunodeficiency Virus Type 1 Resistance to Membrane-Anchored gp41-Derived Peptides
... We conclude that two different ways to circumvent inhibition by fusion inhibitors seem to prevail: first, the mutation of HR1 results in reduced binding of the fusion inhibitor, mainly due to changes in the T-20 binding ... See full document
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