[PDF] Top 20 Cryptococcus neoformans Gene Expression during Murine Macrophage Infection
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Cryptococcus neoformans Gene Expression during Murine Macrophage Infection
... the expression profile, ...the expression of several genes using nonamplified RNA samples as template, and its highly sensitive and quantitative nature enabled analysis of samples of limited ...The ... See full document
14
Invasion of the Central Nervous System by Cryptococcus neoformans Requires a Secreted Fungal Metalloprotease
... C. neoformans’ cell surface and secreted proteins in CNS invasion (17, ...the expression of extracellular phospholipase B (29, 35), urease (11, 12), and laccase (34) con- tributes to the ability of ...C. ... See full document
13
Macrophage M1/M2 Polarization Dynamically Adapts to Changes in Cytokine Microenvironments in Cryptococcus neoformans Infection
... Real-time PCR. For real-time quantitative PCR (qPCR), mRNA was reverse transcribed into cDNA using the QuantiTect reverse transcription kit from Qiagen (Valencia, CA) according to the manufacturer’s instruc- tions. ... See full document
10
Microevolution During Serial Mouse Passage Demonstrates FRE3 as a Virulence Adaptation Gene in Cryptococcus neoformans
... increased expression of the gene after mouse ...sion during mouse passage also developed better iron-dependent growth, better survival in the ...J774.16 macrophage-cell line, and increased ... See full document
11
Lipid Flippase Subunit Cdc50 Mediates Drug Resistance and Virulence in Cryptococcus neoformans
... several macrophage-secreted pro- teins required for the recognition have been reported, such as milk fat-globule epidermal growth factor 8 (MFG-8), growth arrest- specific 6 (Gas6), and protein S (PROS), as ... See full document
13
The Cryptococcus neoformans Transcriptome at the Site of Human Meningitis
... transcriptomes during infec- tion in the CNS has demonstrated a series of important ...their infection, the tran- scriptomes from these strains are remarkably similar and suggest that a specific consensus ... See full document
10
Identification of Pathogen Genomic Differences That Impact Human Immune Response and Disease during Cryptococcus neoformans Infection
... It was unavoidable that, even after we minimized the number of tests and imple- mented the variant class criteria described above, some of the identified variant ⫻ trait associations would represent false positives. To ... See full document
22
Induction of Protective Immunity to Cryptococcal Infection in Mice by a Heat Killed, Chitosan Deficient Strain of Cryptococcus neoformans
... C. neoformans could confer complete protective immunity came from studies of a ...C. neoformans H99 strain that was engineered to express and secrete murine gamma interferon ...C. neoformans ... See full document
14
Chloroquine induces human mononuclear phagocytes to inhibit and kill Cryptococcus neoformans by a mechanism independent of iron deprivation
... to Cryptococcus neoformans are common in AIDS ...C. neoformans multiplied within monocyte-derived macrophages (MDM) in the absence of chloroquine but were killed with the addi- tion of ...C. ... See full document
8
Epidemiological Evidence for Dormant Cryptococcus neoformans Infection
... C. neoformans within all individuals. Why infection would be caused by a dormant strain of ...C. neoformans would assume, and why some isolates would be more virulent than others remain to be ...the ... See full document
6
Role of an Expanded Inositol Transporter Repertoire in Cryptococcus neoformans Sexual Reproduction and Virulence
... ITR1 expression, while addition of inositol to the medium triggers repression of ITR1 expression and inhibits uptake activity ...inositol during host infection ...ITR gene, but it is ... See full document
14
Dynamics of Cryptococcus neoformans Macrophage Interactions Reveal that Fungal Background Influences Outcome during Cryptococcal Meningoencephalitis in Humans
... IMPORTANCE Cryptococcus neoformans is a life-threatening human fungal pathogen that is responsible for an estimated 1 million cases of meningitis/year, predominantly in HIV-infected ...addition, gene ... See full document
10
Cryptococcus neoformans Gene Expression during Experimental Cryptococcal Meningitis
... Response to stress. Several tags corresponded to genes known to be involved in protein folding and the response to heat stress (Table 2). Heat shock proteins are produced in cells under conditions of stress and allow ... See full document
14
Microevolution of Serial Clinical Isolates of Cryptococcus neoformans var grubii and C gattii
... of Cryptococcus are encapsulated yeasts that normally reside in the environment, where they readily become airborne and can infect humans through ...pulmonary infection, they can spread to the central ... See full document
18
Ab binding alters gene expression in Cryptococcus neoformans and directly modulates fungal metabolism
... When H99 was bound by the mAb 18B7, a variety of genes involved in metabolism, secre- tion, and fatty acid synthesis were upregulated. We focused on the genes involved in fatty acid synthesis, because it appeared that an ... See full document
8
Detection and quantitation of the glucuronoxylomannan like polysaccharide antigen from clinical and nonclinical isolates of Trichosporon beigelii and implications for pathogenicity
... C. neoformans serotype A GXM and group B Neisseria meningitidis capsular polysaccharide were used as positive and negative controls, ...Hyperimmune murine GXM antiserum was added to this blocking solution ... See full document
5
Pulmonary Cryptococcus infections as a manifestation of idiopathic CD4 lymphocytopenia: case report and literature review
... The patient underwent an interventional radiology guided transthoracic biopsy, which was complicated with development of small apical pneumothorax and subse- quent chest tube insertion. Histological examination re- ... See full document
5
Cryptococcosis Serotypes Impact Outcome and Provide Evidence of Cryptococcus neoformans Speciation
... mainly for serotype A using PCR fingerprinting, multilocus se- quence typing (MLST), or variable-number tandem repeat (VNTR) methods (7, 17, 19–24). The majority of serotype A iso- lates exhibit clonal expansion with ... See full document
12
Unraveling Melanin Biosynthesis and Signaling Networks in Cryptococcus neoformans
... Among the upstream regulators of the four melanin-regulating core TFs, the Gsk3- dependent signaling pathway appears to be the most important. We found that Gsk3 was required for full induction of LAC1, induction and ... See full document
21
Defect in intracellular killing of Staphylococcus aureus within alveolar macrophages in Sendai virus infected murine lungs
... aureus in the murine lung during Sendai virus infection is impaired through a defect in the intracellular processing mechanisms of the alveolar macrophage and not during the ingestion ph[r] ... See full document
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