[PDF] Top 20 Human Cytomegalovirus-Encoded Immune Modulators Partner To Downregulate Major Histocompatibility Complex Class I Molecules
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Human Cytomegalovirus-Encoded Immune Modulators Partner To Downregulate Major Histocompatibility Complex Class I Molecules
... the human cytomegalovirus (HCMV) has developed a variety of strategies to avoid immune recognition and ...The major histocompatibility complex (MHC) class I antigen ... See full document
9
Expression of m157, a Murine Cytomegalovirus-Encoded Putative Major Histocompatibility Class I (MHC-I)-Like Protein, Is Independent of Viral Regulation of Host MHC-I
... with human cytomegalovirus can cause severe and fatal disease in neonates and immunocompromised individuals (9, ...Although cytomegalovirus infection is species trophic, murine cytomegalovirus ... See full document
6
Genetic Variability of the Major Histocompatibility Complex Class I Homologue Encoded by Human Cytomegalovirus Leads to Differential Binding to the Inhibitory Receptor ILT2
... Human cytomegalovirus carries a gene, UL18, that is homologous to cellular major histocompatibility com- plex (MHC) class I ...MHC class I molecules, the ... See full document
10
Coxsackievirus B3 Proteins Directionally Complement Each Other To Downregulate Surface Major Histocompatibility Complex Class I
... MHC class I ...MHC class I would be seen with the 3A protein (which destroys the Golgi complex), followed by 2BC and 2B (which leave this organelle intact but restrict its ...MHC ... See full document
13
Human Cytomegalovirus Protein US2 Interferes with the Expression of Human HFE, a Nonclassical Class I Major Histocompatibility Complex Molecule That Regulates Iron Homeostasis
... or immune responses (6, 8, 25, 26, 30, 36). By virtue of being a class I MHC molecule, HFE complexes might be modulated by viral anti- gens and might thus manifest another target for virus manip- ... See full document
6
The Epstein-Barr Virus-Encoded BILF1 Protein Modulates Immune Recognition of Endogenously Processed Antigen by Targeting Major Histocompatibility Complex Class I Molecules Trafficking on both the Exocytic and Endocytic Pathways
... strong immune responses, Epstein-Barr virus (EBV) has colonized more than 90% of the adult human ...host immune responses and viral immune ...of major histocompatibility ... See full document
11
Human Cytomegalovirus US2 Endoplasmic Reticulum-Lumenal Domain Dictates Association with Major Histocompatibility Complex Class I in a Locus-Specific Manner
... The human cytomegalovirus-encoded US2 glycoprotein targets endoplasmic reticulum-resident major his- tocompatibility complex (MHC) class I heavy chains for rapid ... See full document
8
Macrophages Escape Inhibition of Major Histocompatibility Complex Class I-Dependent Antigen Presentation by Cytomegalovirus
... MHC I-subversive glycoproteins of MCMV control the MHC I pathway in MEF but fail to downregulate MHC I molecules in infected ...MHC class I molecules differs ... See full document
8
Characterization of a Murine Cytomegalovirus Class I Major Histocompatibility Complex (MHC) Homolog: Comparison to MHC Molecules and to the Human Cytomegalovirus MHC Homolog
... an immune response, this response usually fails to completely resolve the ...primed immune system, CMVs have developed various means of modulating the host immune ...both human and murine CMVs ... See full document
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Structural and Functional Dissection of Human Cytomegalovirus US3 in Binding Major Histocompatibility Complex Class I Molecules
... There are several possible mechanisms by which the luminal domain of US3 could mediate ER retention. First, although US3 does not contain any of the known linear sequences sig- naling for ER retention, it is possible ... See full document
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Down-regulation of major histocompatibility complex class I synthesis by murine cytomegalovirus early gene expression.
... The results indicate that MCMV infection down-regulates synthesis of both H-2Kb and H-2Db and slows considerably the rates of accumulation and maturation of these molecules within the in[r] ... See full document
7
Human Herpesvirus 7 U21 Downregulates Classical and Nonclassical Class I Major Histocompatibility Complex Molecules from the Cell Surface
... by class I major histocompatibility complex (MHC) molecules as a means to escape detection by cytotoxic T lym- phocytes ...destroy class I molecules (2, 26, ... See full document
14
Human Cytomegalovirus Protein US11 Provokes an Unfolded Protein Response That May Facilitate the Degradation of Class I Major Histocompatibility Complex Products
... US11-mediated degradation of HC is not affected by modu- lation of UPR in U373 cells. We used a dominant negative ATF6 construct (30) and a dominant negative XBP-1 construct (13) to further explore the influence of the ... See full document
12
Human Cytomegalovirus pp71 Stimulates Major Histocompatibility Complex Class I Presentation of IE1-Derived Peptides at Immediate Early Times of Infection
... against human  -actin (Rockland, Gilberts- ville, PA, USA; distributed by Biotrend, Köln, Germany) was diluted 1:400 to 1:2,000, the monoclonal antibody directed against IE1 (p63-27 [36]) was diluted 1:125 to ... See full document
10
Downregulation of Major Histocompatibility Complex Class I Molecules by Kaposi's Sarcoma-Associated Herpesvirus K3 and K5 Proteins
... MHC class I molecules ...more complex strategy to prevent class I ...which downregulate class I-mediated antigen presentation (20, ... See full document
10
Rapid degradation of the heavy chain of class I major histocompatibility complex antigens in the endoplasmic reticulum of human cytomegalovirus-infected cells.
... In HCMVinfected HEL, the heavy chain was synthesized at an increasing rate, but instead of being transported to the cell surface through the Golgi apparatus, it was retained in the ER wi[r] ... See full document
11
Identification of the mouse cytomegalovirus genomic region affecting major histocompatibility complex class I molecule transport.
... (Dianova). Immune com- plexes were retrieved with protein A-Sepharose (75 m l of a 1:1 buffer-Sepharose ...MHC molecules were performed sequen- tially with ascitic fluids of MAb 34-5-8s followed by a ... See full document
8
Analysis of Pigtail Macaque Major Histocompatibility Complex Class I Molecules Presenting Immunodominant Simian Immunodeficiency Virus Epitopes
... MHC molecules was adapted from similar methods to detect rhesus macaque (Weinfurter et ...and human MHC alleles (7). Approximately 700 bp of MHC class I cDNA spanning exons two and three ... See full document
12
The role of major histocompatibility complex molecules in luteal function
... express class II MHC molecules ...expressing class II MHC in the CL is somewhat in question. Class II MHC expression is typically limited to cells of the immune system that are regarded ... See full document
7
Immune Modulator Adamantylamide Dipeptide Stimulates Efficient Major Histocompatibility Complex Class I-Restricted Responses in Mice
...  -Gal. A dose-dependent proliferative response was observed in mice immunized with either  -Gal alone or  -Gal coadmin- istered with AdDP but not in control mice (Fig. 4). A slightly stronger response was observed in ... See full document
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