[PDF] Top 20 Dendritic cells in autoimmune diabetes
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Dendritic cells in autoimmune diabetes
... In order to determine the role of dendritic cell subsets in the transfer of autoimmune diabetes, irradiated recipient mice expressing model autoantigen in the islet can be reconstituted [r] ... See full document
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CCR4 bearing T cells participate in autoimmune diabetes
... between cells used in the experiments described here and those used by other ...T cells within bulk populations. Based on the observations that cells expressing the functional lig- and for CCR4, ... See full document
13
Transfer of hematopoietic stem cells encoding autoantigen prevents autoimmune diabetes
... hematopoietic cells and not on the inadvertent transfer of immunoregulatory cells in whole or T cell–depleted ...II–expressing cells, we conclude that diabetes prevention is mediated by the ... See full document
8
Involvement of dendritic cells in autoimmune diseases in children
... defense mechanism against infection. From this profiling data, the authors hypothesized a model of disease patho- genesis that involves a repetitive cycle of muscle injury in which both INF-α/β and INF-γ cascades lead to ... See full document
7
Preventing autoimmune arthritis using antigen specific immature dendritic cells: a novel tolerogenic vaccine
... The blockade of NF-κB activation has been used therapeuti- cally to generate immature DC by Saemann and colleagues [33] using the thiol antioxidant pyrolidine dithiocarbamate. These DC were able to inhibit alloreactive ... See full document
11
In situ analysis of pancreatic islets in rats developing diabetes Appearance of nonendocrine cells with surface MHC class II antigens and cytoplasmic insulin immunoreactivity
... endocrine cells has been proposed to induce autoimmune reactions in thyroid and endocrine ...islet cells occur at the onset of diabetes in rats, in analogy to the findings in ...of ... See full document
7
GAD65 reactive T cells are activated in patients with autoimmune type 1a diabetes
... Studies have indicated that CTLA-4 has a negative regulatory function in T cell activation. CTLA-4 binds to B7 molecules with higher affinity than CD28. It has been shown that soluble anti–CTLA-4 mAb, as well as its F(ab ... See full document
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Infection of peripancreatic lymph nodes but not islets precedes Kilham rat virus-induced diabetes in BB/Wor rats.
... These findings suggest that widespread infection of peripancreatic and other lymphoid tissues but not pancreatic beta cells by KRV triggers autoimmune diabetes by perturbing the immune s[r] ... See full document
6
In vitro studies implicate an imbalanced activation of dendritic cells in the pathogenesis of murine autoimmune pancreatitis
... It thas been shown that murine DCs are capable of activating syngeneic naïve T-cells in vitro even in the absence of foreign antigen [33]. Indeed, we observed a cDC-dependent proliferation of syngeneic ... See full document
15
Clinical and immunological control of experimental autoimmune encephalomyelitis by tolerogenic dendritic cells loaded with MOG-encoding mRNA
... knowledge of the disease-related antigens. In the set- ting of MS, there are indications that the adaptive autoimmune reaction is directed toward myelin pro- teins, including MOG, myelin basic protein (MBP), and ... See full document
20
Pernicious Anemia Associated Autoimmune Diseases in a Sub Saharian African Internal Medicine Service
... an autoimmune disease. It is characterized by the presence of an autoimmune atrophic gastritis and various autoantibodies that lead to a vitamin B12 deficiency responsible for a macrocytic ...parietal ... See full document
6
Variation of C peptide decay rate in diabetic patients with positive glutamic acid decarboxylase antibody: better discrimination with initial fasting C peptide
... positive autoimmune diabetes, it is likely that the beta cell destruction continues after diagnosis, with varying rate until the beta cells are depleted ... See full document
7
Combination of double negative T cells and anti thymocyte serum reverses type 1 diabetes in NOD mice
... T cells that are capable of downregulating the immune response comprise only 1–5 % of αβ T cell receptor (TCR)+ T cells in the peripheral lymphoid tis- sue of normal mice and humans ...T cells also ... See full document
9
Expression of αvβ8 integrin on dendritic cells regulates Th17 cell development and experimental autoimmune encephalomyelitis in mice
... Th17 cells promote a variety of autoimmune diseases, including psoriasis, multiple sclerosis, rheumatoid arthritis, and inflammatory bowel ...T cells to Th17 cells, but the mechanisms ... See full document
10
Inflammatory monocytes and the pathogenesis of viral encephalitis
... marrow-derived cells that are recruited to sites of infection and inflammation in many models of human diseases, including those of the central nervous system ...macrophages, dendritic cells and ... See full document
10
Chemokine receptors on dendritic cells promote autoimmune reactions
... muscularly or as recombinant fusion proteins. The results revealed that Id or sFv by themselves were not immuno- genic [12,13]. Furthermore, mixtures of chemokines or murine β defensins (mBD2 and mBD3) and Id had no sig- ... See full document
6
In vivo multi-modal imaging of experimental autoimmune uveoretinitis in transgenic reporter mice reveals the dynamic nature of inflammatory changes during disease progression
... Experimental autoimmune uveoretinitis (EAU) is an organ-specific, T-cell mediated disease that can be induced in susceptible mouse strains by direct immunization with retinal antigens, including interphotoreceptor ... See full document
12
Molecular mechanisms of T cells activation by dendritic cells in autoimmune diseases
... In the process of T cell and DC interaction, a variety of transmembrane molecules accumulate in a “raft” structure that is rich in sphingomyelin and cholesterol, and are clustered at the interface of T cell and DC ... See full document
10
Exosomes derived from statin-modified bone marrow dendritic cells increase thymus-derived natural regulatory T cells in experimental autoimmune myasthenia gravis
... II and CD28-CD80/CD86 interaction, which leads to the generation of thymic Treg cell precursors (pre-Treg cells). However, there were no differences among the three groups in the expression of MHC II as well as ... See full document
12
Gene silencing of IL 12 in dendritic cells inhibits autoimmune arthritis
... immune responses [14-17]. The recent FDA approval of Provenge as an antigen-specific immunotherapy for prostate cancer attests to the ability of this approach to be translated clinically [18]. Although exceptions exist, ... See full document
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