[PDF] Top 20 Determinants of the Establishment of Human Immunodeficiency Virus Type 1 Latency
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Determinants of the Establishment of Human Immunodeficiency Virus Type 1 Latency
... the establishment of latent ...the virus latently integrated. A second possibility is that the virus integrates but never actively expresses its ...of latency establishment would be ... See full document
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Proteasome inhibitors act as bifunctional antagonists of human immunodeficiency virus type 1 latency and replication
... There are potential explanations for PI-mediated acti- vation of latent HIV-1. First, there is increasing evidence that the 26S proteasome and/or individual 19S and 20S proteasome subparticles can regulate ... See full document
15
Determinants of Entry Cofactor Utilization and Tropism in a Dualtropic Human Immunodeficiency Virus Type 1 Primary Isolate
... for human immunodeficiency virus type 1 (HIV-1) tropism has been clarified recently with the discovery that chemokine receptors, members of the large seven-trans- membrane family ... See full document
7
Establishment of a stable, inducible form of human immunodeficiency virus type 1 DNA in quiescent CD4 lymphocytes in vitro.
... of virus production, at 7 days following each mitogen induction, that equaled the levels of virus produced during parallel infections of fully proliferating CD4 lymphocytes stimulated with mito- gen 3 days ... See full document
12
c-Myc and Sp1 Contribute to Proviral Latency by Recruiting Histone Deacetylase 1 to the Human Immunodeficiency Virus Type 1 Promoter
... proviral human immunodeficiency virus type 1 (HIV-1) and may deplete proviral infection in ...HIV latency, we sought cellular mRNAs whose expression was diminished in ... See full document
10
Novel Pathway for Induction of Latent Virus from Resting CD4+ T Cells in the Simian Immunodeficiency Virus/Macaque Model of Human Immunodeficiency Virus Type 1 Latency
... Epstein-Barr virus (EBV)-transformed, human B-lymphoblastoid cell line (LCL), with CEM, a CD4 ⫹ human T-cell tumor line ...healthy human B lymphocytes. Jurkat is a human CD4 ⫹ -T-cell ... See full document
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Simian Immunodeficiency Virus Integration Preference Is Similar to That of Human Immunodeficiency Virus Type 1
... the establishment of latently infected populations of cells (7, ...in human tissue culture cells by acute infection with a replica- tion-competent SIV ... See full document
6
Gag Determinants of Fitness and Drug Susceptibility in Protease Inhibitor-Resistant Human Immunodeficiency Virus Type 1
... patient-derived virus (patient 2, GenBank accession number FJ224364) was linked to the mutant pro- tease (8Pt2Pt1Pro, ...Figure 1 shows the amino acid changes in the matrix and capsid to the SpeI site from ... See full document
8
Efficient replication of human immunodeficiency virus type 1 requires a threshold level of Rev: potential implications for latency.
... To determine whether a functional threshold level of Rev is required to allow efficient HIV-1 replication, CD4-positive HeLa cells, constitutively expressing a Rev-deficient provirus, we[r] ... See full document
5
V3-independent determinants of macrophage tropism in a primary human immunodeficiency virus type 1 isolate.
... Human immunodeficiency virus type 1 isolates differ in their ability to productively infect macrophages, and several groups have mapped the genetic basis for macrophage tropism to ... See full document
7
Determinants of Human Immunodeficiency Virus Type 1 Resistance to Membrane-Anchored gp41-Derived Peptides
... amino acid 117 to 150 of gp41). Both block the formation of the hairpin structure in a way similar to enfuvirtide (4, 34, 40). A wide range of susceptibility to enfuvirtide has been de- scribed in virus isolates ... See full document
10
Mutations in the tat Gene Are Responsible for Human Immunodeficiency Virus Type 1 Postintegration Latency in the U1 Cell Line
... of virus infection, this mutation was introduced into the HIV molecular clone, pILIC (16) by site-directed mutagen- ...boldface type) and a selec- tion oligonucleotide changing a unique AatII site in pUC19 ... See full document
5
Molecular determinants for cellular uptake of Tat protein of human immunodeficiency virus type 1 in brain cells.
... Not only is understanding the precise mechanisms underly- ing the internalization of extracellular Tat important in deter- mining its role in regulating viral and host function, but this phenomenon could also potentially ... See full document
5
Identification of Determinants on a Dualtropic Human Immunodeficiency Virus Type 1 Envelope Glycoprotein That Confer Usage of CXCR4
... augmented infectivity for CXCR4-expressing HOS-CD4 cells, suggesting a functional interaction between the V1/V2 and V3 regions of gp120, consistent with earlier reports (2, 7, 10, 23, 26, 35, 41). However, while the ... See full document
7
Dual regulation of silent and productive infection in monocytes by distinct human immunodeficiency virus type 1 determinants.
... These include productive infection, with the generation of high virus replication levels; silent infection, with low to undetectable virus replication in monocytes, despite ultimate viru[r] ... See full document
7
Identification of Two Distinct Human Immunodeficiency Virus Type 1 Vif Determinants Critical for Interactions with Human APOBEC3G and APOBEC3F
... codon-optimized HIV-1 Vif expression vector. The initial panel of mutants targeted Vif residues 2 to 60. Because some of the single-residue mutants were already constructed (for example, W11A and I18A), the double ... See full document
10
Herpes Simplex Virus type 1 lytic viral gene expression during the establishment and maintenance of latency
... One of the major sources for concern when using a genome editing methodology such as CRISPR/Cas9 is the potential for off-target effects, in which a mutation, typically a small insertion or deletion, occurs at an ... See full document
353
Determinants of Human Immunodeficiency Virus Type 1 Envelope Glycoprotein Activation by Soluble CD4 and Monoclonal Antibodies
... Human immunodeficiency virus type 1 (HIV-1) is the etio- logic agent of AIDS (5, 29, ...mediate virus entry into target cells (20, 34, 40, 53, 57, 58, 70, ...in ... See full document
7
Determinants of Tetherin Antagonism in the Transmembrane Domain of the Human Immunodeficiency Virus Type 1 Vpu Protein
... some extent here too, although these proteins now do not target CD4. HIV-1 group O Vpu proteins, by contrast, are devoid of tetherin antagonistic activity, while remaining capa- ble of targeting CD4 (53). We note ... See full document
13
Determinants of Syncytium Formation in Microglia by Human Immunodeficiency Virus Type 1: Role of the V1/V2 Domains
... CCR3 use predominates (30). Therefore, the formation of syncytia in microglial cells likely involves the interaction of HIV with those coreceptor molecules that are now considered to be the most important coreceptors in ... See full document
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