[PDF] Top 20 Developments in the scientific and clinical understanding of inflammatory myopathies

... distinct clinical entity known as the antisynthetase syndrome, which will be described ...the inflammatory infiltrates in the muscle tissue of dermatomyositis patients, B cells have been suggested to have a ... See full document

... the clinical and scientific understanding of the spondyloarthritides (SpA), which can be separated in predominantly axial and predominantly peripheral ...The clinical progress includes the ... See full document

... NLRP3 is expressed in granulocytes, dendritic cells, B and T lymphocytes, epithelial cells of the oral and genital tracts, and chondrocytes. It encodes a protein that has a PYD, a nucleotide-binding site domain, and a ... See full document

... Our understanding of fibromyalgia (FM) has made significant advances over the past ...our understanding of the biological basis and the genetic underpinning of FM increases, we hope to gain a better under- ... See full document

... an inflammatory response from leukocytes and synovial cells to trigger the release of cytokines that amplify the local inflammatory ...our understanding of uric acid metabolism in humans, in ... See full document

... pro- inflammatory mediators through TLRs has enriched our understanding of initiation and amplification of autoimmunity and ...improved understanding of the diverse clinical manifes- tations ... See full document

... our understanding of the upstream mechanisms that eventually lead to a destructive inflammatory reaction has received less ...the scientific community that changing RA from a manage- able into a ... See full document

... While the signature pathologic feature of OA is hyaline articular cartilage loss, it is increasingly recognized that OA is a disease of the whole joint and that all structures are affected [2]. Not only is hyaline ... See full document

... in understanding the immune mechanisms in ...in clinical subsets of myositis was demonstrated in the original observations of different cellular subsets in muscle tissue by Arahata and Engel [6,7,9] and is ... See full document

... the clinical point of view, we think that the identification of uncovered areas could be useful for the establishment of additional ...the scientific point of view, by considering that CPGs are ... See full document

... in clinical practice also should be followed using composite indices and ought to be tightly controlled, the significant effect of switching therapy if predefined low disease activity criteria are not reached ... See full document

... In the broad spectrum of non-inflammatory toxic myopa- thies, those induced by drugs represent one of the most frequent diagnoses to be considered in the diagnostic approach of a patient presenting with muscle ... See full document

... Neuropsychiatric SLE (NPSLE) is a clinical category that comprises a multitude of syndromes whose mechanisms probably vary significantly. At least some of these manifes- tations, however, may result from the ... See full document

... In recent population studies, genome-wide linkage scans have highlighted several specific genes involved in disease risk [15]. Chromosome 2q was positive in several scans, suggesting that this chromosome is likely to ... See full document

... to clinical studies that initially evaluated OPG but then switched to an antibody to ...I clinical study demonstrated efficacy similar to that with OPG in terms of rapidly reducing biochemical markers of ... See full document

... Clinical and laboratory features of DM/PM patients All patients and NC were matched for age, sex, and eth- nicity (Table 1). DM patients have higher incidence of interstitial lung disease (ILD) than PM patients ... See full document

... a clinical syndrome with characteristic symptoms and physical fi ndings, while ‘ cardiac dysfunc- tion ’ is a condition of cardiac pathology demonstrated by various cardiac imaging techniques, but without clin- ... See full document

... Figure 1 Relative expression of IFNγ (A), CIITA (B), HLA- DRB (C), HLA-DMB (D), HLA-DOB (E), HLA-DPB (F), GBP2 (G) and ISG15 (H) in NAM, DM, ASM and IBM. *P<0.05; **P<0.01; ***P<0.001. ASM, anti-synthetase ... See full document

... the clinical evidence to date suggests that PAN has a generally acceptable tolerability ...in clinical studies are diarrhea, fatigue, nausea, peripheral edema, decreased appetite, pyrexia, and ... See full document

... At this time, it is unclear what factors/cytokines regu- late AMPD1 levels in skeletal muscle. Evaluation of the AMPD1 promoter has indicated that cytokines are likely to modulate AMPD1 expression in skeletal muscle. For ... See full document