[PDF] Top 20 Digital mammographic density and breast cancer risk: a case–control study of six alternative density assessment methods

... larger breast volumes and, hence, higher dense volumes than those with lower ...All methods showed positive associations of PD with risk, but with the magnitude being greatest for Volpara and ... See full document

... Conclusions Mammographic density offers the potential, alone or in combination with other genetic and non-genetic factors, to improve breast cancer risk prediction [25]; to target pri- ... See full document

... Our study is one of the first to demonstrate that density assessments using Cumulus on processed Hologic FFDM images for clinical display can be highly reproducible and strongly associated with ... See full document

... cohort study, which started recruiting participants from the Melbourne metropolitan area between 1990 and ...At study entry there were 41,514 participants (including 24,469 women) aged be- tween 27 and 76 ... See full document

... Methods Study population The study was nested within the catchment population of the Stockholm Breast Cancer Register, a population- based register of all breast cancer ... See full document

... Methods Study population The study was nested within the catchment population of the Stockholm Breast Cancer Register, a population- based register of all breast cancer ... See full document

... MD assessment method/type of image combina- tions examined ...on breast cancer risk factors were self-reported but as density is not rou- tinely assessed in the UK, and hence women are ... See full document

... stronger density-risk association seen in studies of incident cancer (cancer diagnosed after a negative screen) compared with prevalent cancer (density assessment and ... See full document

... experience. Study 2 examined the relationship between mammo- graphic density in mammograms prior to the detection of cancer, and in matched controls that subsequently remained cancer ...which ... See full document

... and breast density in relation to breast cancer risk or the abil- ity to separate breast cancer from non-breast cancer cases used area-based percent ... See full document

... Computer-assisted methods might be a better choice, but they are not exempt from subjectivity, require specific training, and are labor intensive and difficult to incorpo- rate into mass screening ...excess ... See full document

... the study were dis- cussed in our previous report ...in breast cancer diagnosis by analyzing cases by their detection mode and tumor ...a risk factor for disease, we found that both DA or PDA ... See full document

... for mammographic density as an independent risk factor for breast cancer, describe the risk prediction models that have incorporated density, and discuss the current and ... See full document

... of breast cancer, past HT use (vs never), and current HT use (vs ...and breast cancer risk, potential confounders of the as- sociation between the exposures and MD, and poten- tial ... See full document

... objective methods. Self-reported assessment tools, such as questionnaires and activity logs/diaries, have long been used and results from studies using self-reported measures of physical activity have ... See full document

... and mammographic density with a measure of shift work close to the time of mammogram ...percent density and may not have reached statistical significance due to small sample ...to breast ... See full document

... our study is that we have detailed medical record information for our cases and controls, including tumour characteristics and treatment informa- tion, as well as other self-reported information relevant to CBC ... See full document

... all study participants had to have an available ...detecting breast cancer, all cases would at least have a mammogram taken at ...contralateral breast cancer) are most common within the ... See full document

... Mediation analysis can formally assess whether a hypothesized factor mediates the effect of an exposure on an outcome. Mediation analyses are often employed to explore the hypothetical causal mechanisms by which a ... See full document

... our study include that it was based on a prospective cohort, that the Swedish personal numbers could be used for complete follow-up, that we had infor- mation on an extensive range of potential confounders, and ... See full document