[PDF] Top 20 Domain Interaction Studies of Herpes Simplex Virus 1 Tegument Protein UL16 Reveal Its Interaction with Mitochondria

... The UL16 tegument protein of herpes simplex virus 1 (HSV-1) is con- served among all herpesviruses and plays many roles during ...This protein has an ... See full document

... the interaction network in which the conserved UL16 tegument protein ...65-kDa protein that we found first in pull-down experiments using GST-UL11 (17) has proven to be the UL21 ... See full document

... capsid-bound tegument proteins and the membrane protein complexes provide linkages that drive the budding process as the mature virion emerges (9, 23, 25, 44, 53, 54, 57, 74, ...sid-bound UL16 and ... See full document

... and UL16 proteins of HSV are con- served among all the herpesviruses, very little is known about their structure and ...an interaction between these proteins (either directly or indirectly) might provide a ... See full document

... membrane protein UL11, which suggested a “bridging” function during cytoplasmic envelopment, but this conjecture has not been ...with UL16-null mutants were examined by electron ...when UL16 was ... See full document

... Whatever its function in the nucleus, it is clear that UL16 is not stably present on the C capsids isolated from this compart- ...UL31-null virus (data not shown), which accumulate in the nucleus ... See full document

... UL11 tegument protein of herpes simplex virus plays a critical role in the secondary envelopment; however, the mechanistic details remain ...direct interaction. In vitro binding ... See full document

... the tegument, which is a protein layer between the nucleocapsid and the ...the tegument, which are thought to facilitate viral envelopment by interacting with other virion ...the interaction ... See full document

... specific interaction between full-length UL16 and the tail of gE, the simplest interpretation of this deletion mutant is that it has lost a regulatory ...C-terminal domain that activate binding of ... See full document

... the virus tegument is a poorly understood process, and the molecular interactions involved in tegument assembly have not yet been ...major herpes simplex virus tegument ... See full document

... defense. Herpes simplex virus 1 (HSV-1) blocks autophagy in fibroblasts and in neurons, and the ...ICP34.5 protein is important for the resistance of HSV-1 to autophagy ... See full document

... although its interaction with pUL41 was diminished ...of protein expression than wt VP16, indicating that a positively charged residue at this position is indeed important for VP16 ...VP16-VP1/2 ... See full document

... The herpes simplex virus 1 (HSV-1) UL25 gene product is a minor capsid component that is required for encapsidation, but not cleavage, of replicated viral ...acids 1 to 50 of ... See full document

... larger domain that is sufficient for the reorganization of ...VP22 interaction with MTs and should now help us to investigate the require- ments for cytoplasmic localization, MT binding, and chromatin ... See full document

... other studies do suggest that UL11 interacts with something in HSV-1-infected ...an interaction of UL11 with either a viral protein(s) or a virally induced cellular ...the protein that ... See full document

... of herpes simplex virus type 1 encodes a 96-amino-acid tegument protein that is myristylated, palmitylated, and phosphorylated and is found on the cytoplasmic faces of nuclear, ... See full document

... of herpes simplex virus type 1 (HSV-1) is a 96-amino-acid tegument protein that accumulates on the cytoplasmic face of internal ...this protein is unknown. Previous ... See full document

... including tegument proteins, glycoproteins, and as- sembled nucleocapsids, converge at cytoplasmic vesicles to be- come incorporated into ...that tegument proteins, glycoproteins, and capsids are ... See full document

... fused protein (VP26-GFP) to the nucleus and for it to bind to ...for protein-protein interaction, F79 and G93, were identified as judged by the localization of GFP to nuclear ...the ... See full document

... Despite its association with various human health problems, our knowledge of the HSV-1 evasion strategies against type I IFN- mediated host innate immunity is still not ...binding tegument ... See full document