[PDF] Top 20 Double-stranded RNA-dependent protein kinase and 2-5A system are both activated in interferon-treated, encephalomyocarditis virus-infected HeLa cells.
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Double-stranded RNA-dependent protein kinase and 2-5A system are both activated in interferon-treated, encephalomyocarditis virus-infected HeLa cells.
... The extent of phosphorylation in the intact cell of the a-subunit of eucaryotic protein synthesis initiation factor eIF2 by the kinase was determined for the first time in this type of s[r] ... See full document
5
Inhibition of L-Deleted Foot-and-Mouth Disease Virus Replication by Alpha/Beta Interferon Involves Double-Stranded RNA-Dependent Protein Kinase
... host protein synthesis (18). As expected, 2-AP treat- ment had little or no effect on WT FMDV ...and/or 2⬘-5⬘A synthetase RNase L in the inhibition of FMDV replication was further investigated in EF ... See full document
6
Double-Stranded RNA Binding of Influenza B Virus Nonstructural NS1 Protein Inhibits Protein Kinase R but Is Not Essential To Antagonize Production of Alpha/Beta Interferon
... B/NS1 protein to prevent PKR ...in infected cells or a rather selective shielding of nu- cleic acids associated with viral ribonucleoprotein remains a subject of further ...the 2 ⬘ -5 ⬘ ... See full document
11
The VP35 Protein of Ebola Virus Inhibits the Antiviral Effect Mediated by Double-Stranded RNA-Dependent Protein Kinase PKR
... VP35 protein facilitates viral polypeptide synthesis that inversely correlates with eIF-2 ␣ ...viral protein production for the recombinant ...Vero cells that were untreated or pretreated with ... See full document
11
Blocking Double-Stranded RNA-Activated Protein Kinase PKR by Japanese Encephalitis Virus Nonstructural Protein 2A
... mutated virus than the wild-type JEV ...viral RNA were higher in the brains of mice inoculated with JEV-WT than in mice inoculated with NS2A-T33I ...mice infected with JEV-WT, as measured by FIG 7 ... See full document
12
Cooperative Roles of Fish Protein Kinase Containing Z-DNA Binding Domains and Double-Stranded RNA-Dependent Protein Kinase in Interferon-Mediated Antiviral Response
... of both PKR and PKZ and a concomi- tant increase of eIF2 ␣ phosphorylation ...(Fig. 2 and 3). There- fore, one interpretation is that IFN might activate both fish proteins, at least partly, even in ... See full document
12
West Nile Virus-Induced Interferon Production Is Mediated by the Double-Stranded RNA-Dependent Protein Kinase PKR
... our system, poly(I:C) was added to the medium [extracellular dsRNA; Ex-poly(I:C)] or transfected into [intracellular dsRNA; Tx- poly(I:C)] WT MEF-G cells, PKR null MEF cells, or PKR- RNase L null MEF ... See full document
11
The Murine Double-Stranded RNA-Dependent Protein Kinase PKR Is Required for Resistance to Vesicular Stomatitis Virus
... on cells of the ...ucts activated or induced following the interaction of IFNs with their cognate ...proteins, 2⬘-5⬘-adenylate synthase/RNase L system, inducible nitric oxide synthase, and ... See full document
6
Double-stranded RNA is a trigger for apoptosis in vaccinia virus-infected cells.
... The interferon (IFN) system is the primary defense mecha- nism against viral infection in mammalian ...of double-stranded RNA (dsRNA), which is not found in detectable amounts in most ... See full document
12
Regulated, stable expression and nuclear presence of reovirus double-stranded RNA-binding protein sigma3 in HeLa cells.
... to double-stranded RNA (dsRNA) (11) and associates with polypeptide m 1 and its cleavage product m 1C to form the outer shell of the mature virion ...host protein synthesis in infected ... See full document
5
The RNA-Binding Protein of a Double-Stranded RNA Virus Acts like a Scaffold Protein
... region and E1 particles with a uniform density in the capsid interior. T ⫽ 1 and T ⫽ 7 capsids are indicated. (B) E5 particles are uniformly full capsids. A contaminant T ⫽ 1 capsid is indicated. Bar ⫽ 50 nm. (C) Gallery ... See full document
14
rRNA cleavage as an index of ppp(A2'p)nA activity in interferon-treated encephalomyocarditis virus-infected cells.
... Identity of one of the rRNA cleavage products from interferon-treated, EMCV-infected HeLa cells with one mediated by 2-5A in a HeLa cell-free system: comparison of partial RNase digests [r] ... See full document
5
Inhibition of binding to initiation complexes of nascent reovirus mRNA by double-stranded RNA-dependent protein kinase.
... Of necessity, experiments designed to examine whether the binding of nascent reovirus mRNA to initiation complexes was preferentially inhibited in the coupled, cell-free system had to be[r] ... See full document
6
Human Immunodeficiency Virus Type 1 Tat Protein Activates Transcription Factor NF-κB through the Cellular Interferon-Inducible, Double-Stranded RNA-Dependent Protein Kinase, PKR
... transactivator protein of human immunodeficiency virus type 1 (HIV-1) (Tat) is a powerful activator of nuclear factor- B (NF- B), acting through degradation of the inhibitor I B- ␣ ...cellular ... See full document
7
Effect of p38 Mitogen-Activated Protein Kinase on the Replication of Encephalomyocarditis Virus
... (EMC) virus, a member of the Cardio- virus genus of the family Picornaviridae, contains a single copy of a positive-sense RNA genome and causes diseases such as type 1 diabetes, encephalitis, and ... See full document
8
Synthesis of (2'-5')oligoadenylate and activation of an endoribonuclease in interferon-treated HeLa cells infected with reovirus.
... could not be explained by the degradation of The 2'-5'An was extracted as described in the text, viral mRNAs during the extraction from IFNand its concentration was calculated per packed[r] ... See full document
7
2-5A accumulates to high levels in interferon-treated, vaccinia virus-infected cells in the absence of any inhibition of virus replication.
... 220 Downloaded from http://jvi.asm.org/ on November 10, 2019 by guest We investigated the effects of interferon treatment on virus yield, protein synthesis, and the 2-5A system in vaccin[r] ... See full document
9
VP3, a Structural Protein of Infectious Pancreatic Necrosis Virus, Interacts with RNA-Dependent RNA Polymerase VP1 and with Double-Stranded RNA
... yeast cells of strain Saccharomyces cerevisiae Y187 (MAT␣) or PJ69-2A (MATa) by selection for growth on medium lacking leucine or tryptophan, ...yeast cells from each mating were plated and scored for ... See full document
12
Vaccinia virus RNA polymerase associated with nuclei of infected HeLa cells.
... RNA polymerase I and vaccinia RNA polymerase were not distinguished in the intact nuclei, but hybridization of 3% of the RNA synthesized by nuclei from infected cells in the presence of [r] ... See full document
9
Stress Granules Regulate Double Stranded RNA Dependent Protein Kinase Activation through a Complex Containing G3BP1 and Caprin1
... contributes to the previously reported antiviral function of G3BP1 against several picornaviruses (27). This mechanism shows that SG formation, through G3BP1 and Caprin1, can induce innate immune activation. These ... See full document
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