[PDF] Top 20 Drosophila Target of Rapamycin Kinase Functions as a Multimer
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Drosophila Target of Rapamycin Kinase Functions as a Multimer
... HE target of rapamycin (TOR) kinases are required for normal growth and development in a variety of eukaryotic species, and their dysregulation is linked to a number of overgrowth syndromes including ... See full document
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Two hits are better than one: targeting both phosphatidylinositol 3-kinase and mammalian target of rapamycin as a therapeutic strategy for acute leukemia treatment
... leukemic cell subset which is enriched in LICs [106]. mTORC1 is activated in almost all (95%) of primary AML samples, as documented by phosphorylation of p70S6K and 4E-BP1 at Thr 389 and Thr 37/46, respectively [107, ... See full document
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TOR signaling in plants: conservation and innovation
... protein kinase that belongs to the phosphatidylinositol 3-kinase-related lipid kinase family (Heitman et ...(FKBP- rapamycin-binding), kinase and FATC domains ...to rapamycin, ... See full document
13
Adipocyte amino acid sensing controls adult germline stem cell number via the amino acid response pathway and independently of Target of Rapamycin signaling in Drosophila
... described (McGuire et al., 2003). UAS-RNAi lines obtained from the Fig. 7. The amino acid response pathway within adipocytes contributes to the control of GSC maintenance. (A,B) Average number of GSCs at 0 or 10 days of ... See full document
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Mechanistic target of rapamycin (mTOR) signaling genes in decapod crustaceans: cloning and tissue expression of mTOR, Akt, Rheb, and S6 kinase in the green crab, Carcinus maenas, and blackback land crab, Gecarcinus lateralis
... expression increases protein synthesis and cell growth (Hall et al., 2007). Over-expression of Rheb-GAP inhibits PG growth (Layalle et al., 2008). By contrast, over-expression of PI3K, an upstream activator of Akt, ... See full document
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Specific roles of Target of rapamycin in the control of stem cells and their progeny in the Drosophila ovary
... the Drosophila ovary respond to diet via insulin ...G2. Target of rapamycin, or TOR, is part of a highly conserved nutrient-sensing pathway affecting growth, proliferation, survival and ...TOR ... See full document
11
Regulation of the Target of Rapamycin Signaling Pathway in Saccharomyces cerevisiae
... proteins SIKE and FGFR1OP2. The N-terminal region of CCM3 mediates heterodimerization with Ste20 kinases, and its C-terminal domain interacts with striatin (24, 39, 67, 75, 131), which also interacts with the regulatory ... See full document
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Berchtold, Doris (2012): TOR complex 2 regulates plasma membrane homeostasis. Dissertation, LMU München: Fakultät für Biologie
... conserved target of rapamycin (TOR) kinases regulate many aspects of cellular ...drug rapamycin and have different cellular functions: whereas the rapamycin- sensitive TORC1 controls ... See full document
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The Phosphatase Subunit Tap42 Functions Independently of Target of Rapamycin to Regulate Cell Division and Survival in Drosophila
... for target of rapamycin (TOR)- mediated signaling in yeast, but its role in higher eukaryotes has not been ...in Drosophila, as disruption of the Tap42 gene does not cause defects in cell growth, ... See full document
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Drosophila larvae lacking the bcl-2 gene, buffy, are sensitive to nutrient stress, maintain increased basal target of rapamycin (Tor) signaling and exhibit characteristics of altered basal energy metabolism
... Thr kinase that positively regulates growth by promoting ribosome biogenesis, protein synthesis, and nutrient import while at the same time negatively regulating the catabolic process of ... See full document
20
PIK3CA activating mutations and chemotherapy sensitivity in stage II–III breast cancer
... (mTOR) [3]. Activation of the PI3K/Akt pathway is involved in the regulation of cell proliferation and suppression of apopto- sis [4]. Activating mutations in the catalytic subunit are onco- genic in vivo [5]. Almost all ... See full document
10
Impact of dual mTORC1/2 mTOR kinase inhibitor AZD8055 on acquired endocrine resistance in breast cancer in vitro
... to target de-regulated growth factor signalling pathways, such as mTOR, has become an important therapeutic approach currently under intense clinical ...mTOR kinase inhibitor AZD8055 as a ... See full document
17
Inhibiting the Mammalian Target of Rapamycin Blocks the Development of Experimental Cerebral Malaria
... Microarray chip processing and data analysis. C57BL/6 mice were infected with PbA or mock infected with saline vehicle and treated with either saline or rapamycin beginning on day 1 p.i. (4 conditions; 4 mice for ... See full document
17
Mesoglycan attenuates VSMC proliferation through activation of AMP-activated protein kinase and mTOR
... Background: Vascular smooth muscle cells (VSMC) proliferation contributes significantly to intimal thickening in atherosclerosis and restenosis diseases. Platelet derived growth factor (PDGF) has been implicated in VSMC ... See full document
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Temsirolimus in the treatment of relapsed or refractory mantle cell lymphoma
... Mantle cell lymphoma (MCL) is an uncommon subtype of non-Hodgkin lymphoma (NHL). Despite having been identified as a clinically and morphologically unique type of lymphoma 20 years ago, MCL lacks a standard-of-care ... See full document
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Competition for nutrients; an emerging role in controlling immune responses
... effector functions including the produc- tion of large amounts of cytokines, a process that demands sub- stantial amounts of energy and cellular ...their functions 4,5 ... See full document
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Insights from yeast into whether the rapamycin inhibition of heat shock transcription factor (Hsf1) can prevent the Hsf1 activation that results from treatment with an Hsp90 inhibitor
... to rapamycin (its growth being inhibited by just 1-2nM rapamycin; ...to rapamycin can be attributed to its high Hsf1 activity, since Hsf1 activation in the absence of heat stress is known to enhance ... See full document
11
Original Article Puerarin modulates autophagy to ameliorate cerebral ischemia/reperfusion injury through JNK signaling pathway
... Abstract: Puerarin, a major isoflavone in radix puerariae, exerts remarkable pharmacological effects on ischemic stroke patients in the clinic. However, the underlying mechanisms of the protective effects of puerarin are ... See full document
11
Mikhail V. Blagosklonny 1
... By 2010, many predictions of the TOR-centric model have been tested and confirmed [7]. In 2010, one prediction remained: “rapamycin will become the cornerstone of anti-aging therapy in our life time.” [7]. Until ... See full document
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Lenvatinib for use in combination with everolimus for the treatment of patients with advanced renal cell carcinoma following one prior anti-angiogenic therapy.
... Pazopanib is a tyrosine kinase inhibitor with targets including VEGFR, PDGFR and KIT. In a phase III, randomised, double blinded, placebo controlled trial, pazopanib demonstrated improved median PFS compared to ... See full document
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